Resistance Management Strategy
Resistance Management Strategy - Related Videos
03:21
Vagus Nerve Stimulation Therapy to Manage Treatment-Resistant Depression
0 Views •
2025
Source: Moeller, S., et al., Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression. J. Vis. Exp. (2019)This video demonstrates a clinical protocol for Vagus Nerve Stimulation (VNS) as an adjunctive neurostimulation therapy for treatment-resistant depression (TRD).
08:46
Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
0 Views •
Cited by 2 •
2015
Drug resistance to targeted therapeutics is widespread and the need to identify mechanisms of resistance--prior to or following clinical onset--is critical for guiding alternative clinical management strategies. Here, we present a protocol to couple derivation of drug-resistant lines in vitro with sequencing to expedite discovery of these mechanisms.
15:03
Building a Better Mosquito: Identifying the Genes Enabling Malaria and Dengue Fever Resistance in A. gambiae and A. aegypti Mosquitoes
0 Views •
Cited by 2 •
2007
In this interview, George Dimopoulos focuses on the physiological mechanisms used by mosquitoes to combat Plasmodium falciparum and dengue virus infections. Explanation is given for how key refractory genes, those genes conferring resistance to vector pathogens, are identified in the mosquito and how this knowledge can be used to generate transgenic mosquitoes that are unable to carry the malaria parasite or dengue virus.
01:34
Early Intervention and Pain Management
0 Views •
2026
All animal procedures described here must be conducted in accordance with institutional animal ethics guidelines and approved by IACUC. All procedures must follow the principles of the 3Rs—Replacement, Reduction, and Refinement—and must be performed by trained personnel. Monitoring Animals for Signs of Pain and Distress Recognizing early signs of pain is essential for ethical animal research. Animals are routinely monitored using behavioral, physical, and physiological parameters that reflect...
08:09
Psychophysiological Assessment of the Effectiveness of Emotion Regulation Strategies in Childhood
0 Views •
Cited by 5 •
2017
A detailed protocol for an experimental paradigm to assess the effectiveness with which children regulate emotion is described. Children are randomly assigned to use specific emotion regulation strategies, negative emotions are elicited with film clips, and changes in subsequent psychophysiology index the extent to which emotion regulation is effective.
FAQs
Repeated exposure to the same control agent favors organisms carrying traits that allow survival, followed by reproduction and transmission of those traits. A resistance management strategy reduces this advantage by limiting unnecessary or prolonged exposure and varying the conditions that determine survival. The result is slower enrichment and spread of resistant organisms within the targeted population.
Rotation changes the selective challenge over time by replacing one mode of action with another. This approach can reduce the repeated advantage given to organisms resistant to a single agent, provided the alternatives differ in how they act. Choosing the sequence requires attention to resistance patterns and exposure conditions so that rotation supports continued control.
Combining treatments applies more than one control pressure, which can reduce the likelihood that an organism with resistance to one agent will survive the full treatment. The value of the combination depends on using agents with different modes of action and applying them under suitable conditions. This makes combination design an important part of preserving control effectiveness.
Untreated refuges maintain a portion of the susceptible population rather than exposing every organism to the control agent. When resistant individuals reproduce with susceptible individuals, the frequency and spread of resistance traits may be limited. Their usefulness depends on how the refuge is maintained and how population reproduction, transmission, and exposure connect treated and untreated areas.
Monitoring tracks resistance patterns and reveals whether the targeted population is becoming less responsive to a control agent. These observations can guide treatment decisions, including whether to rotate agents, combine treatments, or modify exposure practices. Continued surveillance also helps identify changes in resistance frequency and spread, allowing management to respond before control effectiveness declines substantially.
A program begins by identifying the target population, relevant resistance traits, available agents, and exposure conditions. Managers then select practices such as rotation, combination treatment, or refuge maintenance, while recording outcomes and monitoring resistance patterns. The findings support adjustments to later treatment decisions and connect population genetics with practical disease, pest, or weed control.
Resistance management applies across antibiotic treatment, pesticide use, herbicide programs, and other biological control settings. In disease control, it helps inform treatment decisions and surveillance; in agriculture, it supports crop protection and pest management. Across these settings, the central outcome is more sustainable control by slowing resistance evolution and preserving the usefulness of available agents.