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En rotte carotis arterie trykkkontrollert segmental ballong skade med periadventitial terapeutisk applikasjon

Article DOI: 10.3791/60473-v • 06:53 min • July 9th, 2020
July 9th, 2020 •
1,2,3,5, 1,2,3,4,5
1Department of Surgery, Division of Vascular Surgery, University of North Carolina at Chapel Hill, 2Center for Nanotechnology in Drug Delivery, University of North Carolina at Chapel Hill, 3Curriculum in Toxicology & Environmental Medicine, University of North Carolina at Chapel Hill, 4Department of Cell Biology & Physiology, University of North Carolina at Chapel Hill, 5McAllister Heart Institute, University of North Carolina at Chapel Hill

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Rottekarotisarterieballongskaden etterligner den kliniske angioplastikkprosedyren som utføres for å gjenopprette blodstrømmen i aterosklerotiske kar. Denne modellen induserer arteriell skaderespons ved å distending arteriell vegg, og denuding det intimale laget av endotelceller, til slutt forårsaker ombygging og en intimal hyperplastisk respons.

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Medisin Utgave 161 Rottekarotisarterie Ballongskade Vaskulær skade Restenose Neointimal Hyperplasi Periadventitial Drug Delivery Arteriell skaderespons Karombygging Kardiovaskulær sykdom perifer karsykdom vaskulær glatt muskelcelle lysark fluorescerende mikroskopi
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