卒中临床前评估网络多中心实验室溶栓治疗血栓性脑卒中模型：TE-MCAo
932 次观看
•
06:38 分钟
•
2025年12月19日
DOI :10.3791/69522-v
2025年12月19日
•932 次观看
Mozammel Bhuiyan1 , Michelle Lin2 , Carly McCurry1 , Jessica Lamb1 , Marcio A. Diniz3 , Karni Bedirian3 , Anil Chauhan4 , Abhishek Jha4 , Aditi Jain4 , Enrique Leira5 , Mohammad B. Khan6 , Pradip K Kamat6 , David C Hess6 , Huaxin Sheng7 , Bingren Hu8 , Lauren H. Sansing9 , Cenk Ayata10 , Takahiko Imai10 , Kirsten Lynch11 , Patrick Lyden1,12
1Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine of USC, 2Department of Neurosurgery, Keck School of Medicine of USC, 3Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, 4Department of Internal Medicine, Division of Hematology, Oncology and Blood & Marrow Transplantation, Carver College of Medicine, University of Iowa, 5Departments of Neurology & Neurosurgery, Carver College of Medicine, Department of Epidemiology, College of Public Health, University of Iowa, 6The Medical College of Georgia at Augusta University, 7Department of Anesthesiology, Duke University, 8University of California, San Diego, 9Department of Neurology, Yale University, 10Neurovascular Research Unit, Massachusetts General Hospital, 11Laboratory of NeuroImaging, USC Mark and Mary Stevens Neuroimaging and Informatics Institute of the Keck School of Medicine of USC, 12Department of Neurology, Keck School of Medicine of USC
为了模拟血栓栓塞性卒中，将由异源大鼠血液制备的栓子注入大脑中动脉，随后进行全身溶栓治疗以实现血管再通。该模型版本经过优化，适用于多实验室网络研究，并支持对多种候选治疗药物的测试。
Chapters in this video
0:00
Introduction
0:28
Femoral Artery Catheterization and Collection of Blood
2:59
Thrombus Preparation
5:10
Results
5:57
Conclusion
Related Videos