Sheep Carotid Model
Sheep Carotid Model - Related Videos
05:23
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0 Views •
2026
Here, we present an integrated protocol for generating controlled osteochondral lesions in sheep knees to establish an experimental model suitable for bone and cartilage tissue regeneration studies. The protocol outlines a method for inducing a full-thickness osteochondral defect in the femoral condyle, utilizing techniques that minimize animal welfare impacts and variability in results.
03:47
A Murine Model of Carotid Aneurysm Formation
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2025
The present protocol describes a standardized surgical method for the induction of carotid aneurysms in a murine model through a single surgical operation.
04:28
Cannulation of the Carotid Artery in a Rat Model
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2025
In this video, we demonstrate a surgical procedure to cannulate the left carotid artery in a rat model.
04:30
A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
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Cited by 11 •
2013
A model of stent implantation in mouse carotid artery is described. Compared to other similar methods, this procedure is very rapid, simple and accessible, offering the possibility to study in a convenient way the vascular wall reaction to different drug-eluting stents and the molecular mechanisms of restenosis.
09:17
High-Resolution Endocardial and Epicardial Optical Mapping in a Sheep Model of Stretch-Induced Atrial Fibrillation
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Cited by 20 •
2011
This report provides a detailed description of the methodology and results of simultaneous endocardial and epicardial optical mapping of electrical excitation in the intact left atrium of a Langendorff-perfused sheep heart during stretch-induced atrial fibrillation.
FAQs
An implanted construct remains subject to blood flow and vessel mechanics within a living artery, rather than being evaluated only under simplified laboratory conditions. These forces interact with the device and surrounding tissue over time, enabling researchers to examine how design choices affect patency, thrombosis, healing, and remodeling. This supports bioengineering decisions about performance in physiologically relevant conditions.
Patency, thrombosis, healing, and remodeling provide complementary measures of device performance. Patency indicates whether blood flow remains unobstructed, while thrombosis identifies clot-related complications. Healing and remodeling show how the host tissue responds and changes around the implant. Considering these outcomes together helps distinguish short-term function from broader biological compatibility and longer-term limitations.
The sheep carotid artery provides vessel size and anatomy that support evaluation of engineered grafts, drug-delivery systems, and endovascular technologies in a living vascular setting. This geometry helps connect device design with blood-flow behavior, vessel mechanics, and tissue responses. As a result, researchers can assess safety and performance before considering clinical translation.
A study begins with surgical access to the sheep carotid artery, followed by implantation of the selected graft, stent, catheter, or other construct. Researchers then monitor the vessel and implant over time while assessing blood flow, vessel mechanics, and host tissue responses. The resulting observations are related to patency, thrombosis, healing, remodeling, safety, and performance.
The model can support testing of engineered vascular grafts, stents, catheters, drug-delivery systems, and other cardiovascular constructs. Its value lies in placing each design within a functioning vessel, where blood flow and tissue interaction can influence results. Bioengineers can therefore compare how different constructs perform and how their materials or configurations affect vascular outcomes.
Researchers may choose the Sheep Carotid Model when a design requires evaluation in a living vascular environment before clinical translation. It is particularly relevant for studying safety, performance, patency, thrombosis, healing, and remodeling of grafts or endovascular technologies. Longitudinal monitoring also helps reveal changes that a single early assessment might not capture.