Acoustic Wave Separation
Acoustic Wave Separation - Related Videos
12:26
Fabrication, Operation and Flow Visualization in Surface-acoustic-wave-driven Acoustic-counterflow Microfluidics
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Cited by 4 •
2013
In this video we first describe fabrication and operation procedures of a surface acoustic wave (SAW) acoustic counterflow device. We then demonstrate an experimental setup that allows for both qualitative flow visualization and quantitative analysis of complex flows within the SAW pumping device.
10:14
Fabrication and Operation of Acoustofluidic Devices Supporting Bulk Acoustic Standing Waves for Sheathless Focusing of Particles
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Cited by 16 •
2016
Acoustofluidic devices use ultrasonic waves within microfluidic channels to manipulate, concentrate and isolate suspended micro and nanoscopic entities. This protocol describes the fabrication and operation of such a device supporting bulk acoustic standing waves to focus particles in a central streamline without the aid of sheath fluids.
11:32
A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice
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Cited by 9 •
2015
This protocol describes a system architecture for performing automated small volume (0.15–1.5 ml) particle separations using a microfluidic device, and discusses methods to optimize acoustofluidic device performance and operation.
14:22
Activating Molecules, Ions, and Solid Particles with Acoustic Cavitation
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Cited by 6 •
2014
Acoustic cavitation in liquids submitted to power ultrasound creates transient extreme conditions inside the collapsing bubbles, which are the origin of unusual chemical reactivity and light emission, known as sonoluminescence. In the presence of noble gases, nonequilibrium plasma is formed. The "hot" particles and the photons generated by collapsing bubbles are able to excite species in solution.
07:55
Fabrication of Surface Acoustic Wave Devices on Lithium Niobate
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Cited by 23 •
2020
Two fabrication techniques, lift-off and wet etching, are described in producing interdigital electrode transducers upon a piezoelectric substrate, lithium niobate, widely used to generate surface acoustic waves now finding broad utility in micro to nanoscale fluidics. The as-produced electrodes are shown to efficiently induce megahertz order Rayleigh surface acoustic...
FAQs
Particle behavior depends mainly on size, density, and compressibility. These properties affect how strongly acoustic radiation forces act on each suspended object and whether it moves toward or away from a pressure node. Because different cells or biomaterials can respond differently to the same acoustic field, these contrasts provide the basis for sorting within a mixed sample.
Standing waves create a repeating pattern of pressure fluctuations inside the acoustic field. Their pressure nodes provide preferred locations toward which some suspended objects move, while other objects may be driven away. This spatial redistribution concentrates materials according to their physical responses and allows the system to distinguish components without requiring direct mechanical contact.
Acoustic Wave Separation can distinguish suspended biological materials through physical properties rather than added chemical labels. It also avoids relying on a mechanical filter that physically retains particles by a fixed barrier. The label-free, contact-free format is especially relevant when researchers want to prepare or analyze cells and other biomaterials while limiting additional sample handling.
A biological sample is suspended and introduced into a microfluidic system, where an acoustic field acts on its components. Pressure-driven movement then redistributes particles according to their physical properties, enabling selected materials to be sorted or isolated. The resulting separated populations can support subsequent sample preparation or cell analysis, depending on the research objective.
The approach can be applied to several classes of biomaterials, including cells, microorganisms, extracellular vesicles, and other suspended biological particles. This breadth comes from its reliance on physical properties rather than a single biological marker. Consequently, the same general platform can support different sample types in biomedical research, provided their acoustic responses permit separation.
Researchers may use it for sample preparation, cell analysis, and broader biomedical investigations. Its gentle, contact-free operation is relevant when maintaining a biological sample without introducing chemical labels or forcing it through mechanical filters is desirable. The method can therefore provide a way to isolate or organize sample components before additional analysis.