Cancer Studies
Cancer Studies - Related Videos
07:29
Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
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Cited by 27 •
2015
Pancreatic cancer stem cells (CSCs) can be expanded in vitro using the anchorage-independent sphere culture technique, which represents a powerful tool to study CSC biology and can serve as the first step to develop novel CSC-targeting therapies. Here the methodology for expanding, analyzing and targeting of pancreatic CSCs is provided.
13:10
DNA Vector-based RNA Interference to Study Gene Function in Cancer
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Cited by 26 •
2012
RNA interference (RNAi) possesses many advantages over gene knockout and has been broadly used as a tool in gene functional studies. The invention of DNA vector-based RNAi technology has made long term and inducible gene knockdown possible, and also increased the feasibility of gene silencing in vivo.
08:34
Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
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Cited by 3 •
2015
Telomere and telomerase play essential roles in ageing and tumorigenesis. The goal of this protocol is to show how to generate two murine inducible telomerase knock-in alleles and how to utilize them in the studies of tissue degeneration/regeneration and cancer.
07:47
Studying the Role of Alveolar Macrophages in Breast Cancer Metastasis
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Cited by 7 •
2016
Here we describe the model and approach to study functions of pulmonary alveolar macrophages in cancer metastasis. To demonstrate the role of these cells in metastasis, the syngeneic (4T1) model of breast cancer in conjunction with the depletion of alveolar macrophage with clodronate liposomes was used.
09:29
Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
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Cited by 11 •
2020
This work presets an advanced protocol to accurately assess tumor loading by detection of green fluorescent protein and bioluminescence signals as well as the integration of quantitative molecular detection technique.
FAQs
Genetic and epigenetic alterations can disrupt several safeguards at once, rather than affecting only one cancer-related pathway. Changes in cell-cycle control may promote continued division, while impaired DNA repair allows abnormalities to persist and altered signaling can support survival. Studying these interacting defects helps researchers identify mechanisms that drive tumor development and potential therapeutic targets.
Apoptosis, or programmed cell death, normally removes cells that are damaged or no longer needed. When cancer-related changes interfere with this process, abnormal cells may survive alongside defects in cell-cycle regulation or DNA repair. Cancer studies examines how these failures cooperate, which can clarify why tumors persist and where treatment strategies might intervene.
Progression and metastasis represent different levels of tumor behavior. A tumor may first alter or invade surrounding tissues, whereas metastasis refers to spread to other sites. Cancer studies compares these stages by examining how abnormal cells interact with nearby tissue and acquire the capacity to disseminate. This distinction connects biological mechanisms with disease development and treatment research.
Researchers investigate diagnostic biomarkers by connecting measurable biological features with cancer-related processes and clinical findings. Laboratory studies can examine candidate alterations, while clinical research evaluates their relevance in patients, and population research can relate findings to broader patterns. This combined evidence supports more informed detection and contributes to precision medicine.
By linking tumor biology with treatment response, cancer studies helps researchers evaluate therapeutic targets and treatment strategies, including surgery, radiation, chemotherapy, targeted therapy, and immunotherapy. Findings from laboratory and clinical research can support efforts to improve effectiveness while reducing toxicity. This evidence also advances precision medicine by relating cancer characteristics to therapeutic development.
Laboratory work investigates cancer mechanisms and candidate targets, clinical research examines treatment strategies and patient-related findings, and population research investigates risk factors and broader patterns. Together, these approaches connect biological discovery with medical application. Their combined contributions support prevention, diagnosis, therapeutic development, and improvements in patient care.