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Journal / Bioengineering / 建立一种结构逼真的心肌细胞的有限元几何模型研究蜂窝结构在心肌系统生物学中的作用…
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Bioengineering

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JoVE Journal Bioengineering
建立一种结构逼真的心肌细胞的有限元几何模型研究蜂窝结构在心肌系统生物学中的作用
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建立一种结构逼真的心肌细胞的有限元几何模型研究蜂窝结构在心肌系统生物学中的作用

Article DOI: 10.3791/56817-v • 08:54 min • April 18th, 2018
April 18th, 2018 •
1,2,3, 2,3, 1,2,3, 2,4, 5, 6, 2,3,4,7,8, 9
1Cell Structure and Mechanobiology Group, University of Melbourne, 2Systems Biology Laboratory, Melbourne School of Engineering, University of Melbourne, 3Department of Biomedical Engineering, University of Melbourne, 4School of Mathematics and Statistics, Faculty of Science, University of Melbourne, 5Department of Engineering Science, University of Auckland, 6Advanced Microscopy Facility, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 7ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, University of Melbourne, 8School of Medicine, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, 9Living Systems Institute, University of Exeter

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Summary
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该协议概述了一种新的方法, 以建立一个空间详细的有限元模型的细胞内体系结构的电子显微镜和共焦显微图像。通过对钙信号和生物能学的案例研究, 证明了这个空间细节模型的威力。

Tags

生物工程 问题 134 心肌细胞 心脏超微结构 电子显微镜 共焦显微镜 计算模型 有限元模型 系统生物学 钙信号 线粒体 生物能学
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