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Journal / Bioengineering / Å skape et strukturelt realistisk Finite Element…
JoVE Journal
Bioengineering

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JoVE Journal Bioengineering
Å skape et strukturelt realistisk Finite Element geometriske modell av en Cardiomyocyte å studere rollen til mobilnettet arkitektur i Cardiomyocyte Systems Biology
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Å skape et strukturelt realistisk Finite Element geometriske modell av en Cardiomyocyte å studere rollen til mobilnettet arkitektur i Cardiomyocyte Systems Biology

Article DOI: 10.3791/56817-v • 08:54 min • April 18th, 2018
April 18th, 2018 •
1,2,3, 2,3, 1,2,3, 2,4, 5, 6, 2,3,4,7,8, 9
1Cell Structure and Mechanobiology Group, University of Melbourne, 2Systems Biology Laboratory, Melbourne School of Engineering, University of Melbourne, 3Department of Biomedical Engineering, University of Melbourne, 4School of Mathematics and Statistics, Faculty of Science, University of Melbourne, 5Department of Engineering Science, University of Auckland, 6Advanced Microscopy Facility, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 7ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, University of Melbourne, 8School of Medicine, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, 9Living Systems Institute, University of Exeter

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Denne protokollen definerer en ny metode for å opprette en romlig detaljert endelig element modell av intracellulær arkitektur cardiomyocytes fra elektronmikroskop og AC confocal mikroskopi bilder. Kraften i dette romlig detaljert modell er demonstrert ved hjelp av case-studier i kalsium signalisering og Bioenergi.

Tags

Bioteknologi problemet 134 Cardiomyocyte hjerte ultrastructure elektronmikroskop AC confocal mikroskopi beregningsorientert modellering endelig element modellering systemer biologi kalsium signalering mitokondrier bioenergi
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