Breast Tumor Mice
Breast Tumor Mice - Related Videos
07:13
Initiation of Metastatic Breast Carcinoma by Targeting of the Ductal Epithelium with Adenovirus-Cre: A Novel Transgenic Mouse Model of Breast Cancer
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Cited by 27 •
2014
Activation of latent mutations with adenovirus-Cre into the mammary ductal system results in a clinically relevant metastatic breast cancer. Incorporation of a YFP promoter allows tracking of distal metastatic tumor cells. This model is useful to study latent metastasis, anti-tumor immunity, and for designing novel immunotherapies to treat breast cancer.
07:45
Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
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Cited by 15 •
2020
Patient-derived xenograft (PDX) models and transplantable genetically engineered mouse models faithfully recapitulate human disease and are preferred models for basic and translational breast cancer research. Here, a method is described to orthotopically transplant breast tumor fragments into the mammary fat pad to study tumor biology and evaluate drug response.
03:46
Bioluminescent Imaging of Breast Tumor Progression in a Female Mouse Model
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2025
Source: Marina Arantes Radicchi1, Victor Carlos Mello1, Victória Paz Machado1, Márcia Cristina Oliveira da Rocha1, Jaqueline Vaz de Oliveira1, Luana Cristina Camargo1,2, Luís Alexandre Muehlmann1, Ricardo Bentes Azevedo1, Sônia Nair Bao1, João Paulo Figueiró Longo11Institute of Biological Sciences, University of Brasília, 2Department of Basic Psychological Processes, Institute of Psychology, University of BrasíliaThis video demonstrates the procedure for tracking tumor progression in vivo by...
11:02
In vivo Bioluminescence Imaging of Tumor Hypoxia Dynamics of Breast Cancer Brain Metastasis in a Mouse Model
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Cited by 16 •
2011
Bioluminescence imaging of hypoxia inducible factor-1α activity is applied to monitor intracranial tumor hypoxia development in a breast cancer brain metastasis mouse model.
08:26
Live Imaging of Drug Responses in the Tumor Microenvironment in Mouse Models of Breast Cancer
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Cited by 15 •
2013
We describe a method for imaging response to anti-cancer treatment in vivo and at single cell resolution.
FAQs
Researchers establish these models through two principal routes: implanting breast cancer cells or tissue, or introducing genetic alterations that promote abnormal mammary-cell growth. The first route provides a controlled way to study an existing tumor, whereas the second links tumor development to defined biological changes. Choosing between them depends on the cancer process the experiment is designed to examine.
Tumor progression reflects more than cancer-cell behavior alone. In these models, researchers can examine interactions among malignant cells, surrounding stroma, and blood vessels, which together shape the tumor environment. When the model includes an immune system, immune interactions can also be studied. This integrated setting helps connect tumor biology with changes occurring around the cancer.
Some models include an immune system, allowing researchers to consider how immune-related interactions contribute to tumor behavior and treatment response. Other experimental designs may focus primarily on implanted cells or tissue and the surrounding tumor environment. Recognizing this distinction is important because the biological processes represented by a model depend on which components are present.
Breast tumor mice support investigation of several stages and features of disease, including cancer initiation, tumor progression, and metastasis. They also allow researchers to study tumor biology within a living organism rather than examining cancer cells in isolation. These capabilities help link cellular changes to broader disease behavior and provide a basis for testing therapeutic strategies.
An experiment begins by selecting a model design, either implantation of breast cancer cells or tissue or introduction of a tumor-driving genetic alteration. Researchers then follow tumor development and progression in the living mouse, focusing on the biological question under study. The resulting observations can be used to examine metastasis, tumor behavior, or response to a treatment.
Researchers use these models to test potential drugs and therapeutic strategies against tumors in a living-organism context. Treatment response can be considered alongside tumor biology and interactions with surrounding stroma, blood vessels, and, in some models, the immune system. This provides experimental evidence that can guide further investigation before a therapy proceeds to clinical studies.
In medicine, breast tumor mice provide a controlled experimental system for connecting breast cancer mechanisms with possible therapeutic responses. Their use supports studies of initiation, metastasis, tumor biology, and treatment strategies while helping researchers design experiments more precisely. Findings from these studies can improve understanding of disease processes and inform decisions about which approaches merit additional evaluation.