Delayed Graft Function
Delayed Graft Function - Related Videos
07:05
The Precision of Visual Working Memory with Delayed Estimation
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2023
Source: Laboratory of Jonathan Flombaum—Johns Hopkins University Human memory is limited. Throughout most of its history, experimental psychology has focused on investigating the discrete, quantitative limits of memory—how many individual pieces of information a person can remember. Recently, experimental psychologists have also become interested in more qualitative limits—how precisely is information stored? The concept of memory precision can be both intuitive and elusive at once. It is...
07:47
Measuring Delay Discounting in Humans Using an Adjusting Amount Task
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Cited by 55 •
2016
Delay discounting refers to a decline in the value of a reward when it is delayed relative to when it is immediately available. We outline a computer-based delay discounting task that is easy to implement and allows for the quantification of the degree of delay discounting in human participants.
07:37
Mouse Models for Graft Arteriosclerosis
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Cited by 17 •
2013
We describe protocols for our mouse graft arteriosclerois (GA) models which involve interposition of a mouse vessel segment into a recipient of the same inbred strain. By backcrossing additional genetic changes into the vessel donor, the model can assess the effect of specific genes on GA.
11:31
Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols
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Cited by 5 •
2013
The cell membrane modification of red blood cells (RBCs) with hyperbranched polyglycerol (HPG) is presented. Modified RBCs were characterized by aqueous two phase partitioning, osmotic fragility and complement mediated lysis. The camouflage of surface proteins and antigens was evaluated using the flow cytometry and Micro Typing System (MTS) blood phenotyping cards.
13:04
Generation and Grafting of Tissue-engineered Vessels in a Mouse Model
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Cited by 13 •
2015
Here, we present a protocol to generate tissue engineered vessel grafts that are functional for grafting into mice by double seeding partially induced pluripotent stem cell (PiPSC) - derived smooth muscle cells and PiPSC - derived endothelial cells on a decellularized vessel scaffold bioreactor.
FAQs
The central injury develops while the kidney is retrieved, preserved, and implanted, then exposed to restored blood flow. This sequence can disrupt tubular function, so the transplanted kidney may receive circulation without immediately filtering effectively. Understanding that mismatch helps clinicians interpret early postoperative dysfunction and focus on organ-preservation strategies that may reduce injury before transplantation.
Restored circulation does not guarantee immediate recovery of tubular activity. Ischemia-reperfusion injury can impair the tubules responsible for normal kidney performance, producing inadequate filtration even when the graft has been implanted and perfused. This distinction is clinically important because early low function may reflect recovering tissue injury rather than automatically indicating acute rejection.
Injury may accumulate during organ retrieval, preservation, and implantation, making each stage relevant to early graft performance. Conditions affecting the kidney across this sequence can worsen tubular disruption and delay functional recovery. Consequently, research and clinical practice consider preservation methods and handling throughout the transplant pathway rather than focusing only on the implantation procedure.
Clinicians assess the pattern of early graft recovery while monitoring urine output, serum creatinine, electrolytes, and fluid balance. These observations help identify inadequate kidney performance and provide information for comparing delayed recovery with acute rejection or other complications. The distinction matters because early management, immunosuppression decisions, dialysis needs, and graft assessment may differ.
Early management includes repeated assessment of urine output, serum creatinine, electrolyte concentrations, and fluid balance. Together, these measures show whether kidney performance is improving and whether fluid or electrolyte disturbances require attention. Monitoring also supports decisions about dialysis and helps clinicians evaluate the graft while distinguishing temporary delayed recovery from other causes of dysfunction.
The condition can require individualized immunosuppression, dialysis, and ongoing graft assessment during the early post-transplant period. Its presence also makes organ preservation an important research target, because ischemia-reperfusion injury begins before and during implantation. Better understanding and prevention may improve immediate management while supporting efforts to achieve stronger long-term transplant outcomes.