Nose-to-brain Delivery
Nose-to-brain Delivery - Related Videos
03:37
Intranasal Drug Administration in Mice via Pipette and Reverse-Cannulation for Nose-to-Brain Drug Delivery
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2025
Source: Kanazawa, T., et al. Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery. J. Vis. Exp. (2018)This video demonstrates the intranasal administration of radiolabeled drugs in an anesthetized mouse to achieve nose-to-brain drug delivery. It explains how drugs cross the nasal epithelium and travel via neuronal pathways to reach the brain, as well as how ciliary motion influences drug retention and clearance. Additionally, the video...
05:44
Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery
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Cited by 14 •
2018
Here, we describe two novel methods of stable intranasal administration under inhalation anesthesia with minimal physical stress for experimental animals. We also describe a method for quantitative evaluation of drug distribution levels in the brain via the nose-to-brain pathway using radiolabeled [14C]-inulin as a model substrate of water-soluble macromolecules.
02:58
Convection-Enhanced Delivery of Antibodies into a Mouse Brain
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2025
This video demonstrates a convection-enhanced delivery (CED) technique for antibody delivery into the mouse brain. The skull of an anesthetized mouse is exposed, and a burr hole is created at the target area for antibody delivery. A step catheter containing antibodies is inserted at the target site, and via an infusion pump, a pressure gradient is created to deliver antibodies at a controlled rate.
08:46
Nose, Sinuses, Oral Cavity and Pharynx Exam
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2023
Source: Richard Glickman-Simon, MD, Assistant Professor, Department of Public Health and Community Medicine, Tufts University School of Medicine, MA This video provides an overview of sinus, nose, and throat examinations. The demonstration begins with a brief overview of the anatomy of the region. The upper third of the nose is bony, and the bottom two-thirds are cartilaginous. Air entering the nares passes through the nasal vestibules and into the narrow passageway between the nasal septum...
04:05
Intranasal Delivery of siRNA to the Mouse Brain Using a Positioning Device
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2025
Source: Ullah, I., et.al. A Positioning Device for the Placement of Mice During Intranasal siRNA Delivery to the Central Nervous System. J. Vis. Exp. (2019)This video demonstrates a precise intranasal administration technique for delivering neuron-targeting peptide-siRNA complexes to the mouse brain using a specialized positioning device. Anesthetized mice are secured in a head-down-and-forward position to optimize siRNA inhalation while preventing lung drainage. The targeting peptide...
FAQs
After a compound crosses the nasal mucosa, the olfactory and trigeminal nerves can provide routes toward the central nervous system. These pathways are important because they may allow transport that is less dependent on passage through the blood-brain barrier. Their involvement also supports efforts to direct therapeutics toward the brain rather than relying solely on systemic circulation.
Delivery efficiency depends on how well a compound is absorbed through the nasal mucosa, how quickly mucociliary clearance removes material, and how the formulation behaves in the nasal cavity. Limited absorption can reduce the amount available for transport, while rapid clearance can shorten nasal residence. These variables make formulation design central to achieving useful exposure.
Formulation properties influence how a therapeutic molecule interacts with the nasal cavity and whether it remains available long enough for transport. Specialized formulations are used to address limited absorption and mucociliary clearance, which can otherwise reduce delivery efficiency. Improving these characteristics may increase nasal retention and support more consistent access to the central nervous system.
The strategy begins with intranasal administration of a drug or other therapeutic molecule. The material must then remain available in the nasal cavity, cross the nasal mucosa, and access olfactory or trigeminal pathways. Researchers may pair the compound with a specialized formulation or delivery device to improve retention, influence targeting, and enhance the intended therapeutic outcome.
In neuroscience, this approach is investigated for conditions in which access to the brain is important, including neurodegenerative disease, brain tumors, and stroke. Its potential to bypass the blood-brain barrier makes it relevant when conventional delivery may not provide sufficient central nervous system access. The method can support both therapeutic development and disease-focused research.
Specialized delivery devices can help control where and how material is deposited within the nasal cavity. In combination with tailored formulations, they may improve nasal retention and support targeting of particular brain regions through olfactory or trigeminal routes. These design choices are relevant when researchers seek stronger therapeutic effects or more focused investigation of neurological disorders.