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Microfluidic Necrotizing Enterocolitis-on-a-Chip Model for Studying NEC Pathophysiology

A Necrotizing Enterocolitis Model for Mechanistic Studies and Drug Discovery

Article DOI: 10.3791/200450-v • 06:10 min • July 28th, 2023
July 28th, 2023 •
1, 1, 1, 2, 3, 1, 1, 1, 1
1Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of North Carolina at Chapel Hill, 2University of Nebraska College of Medicine, 3Department of Surgery, Washington University School of Medicine

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Microfluidic Model Necrotizing Enterocolitis Human Neonatal Intestinal Enteroids Dysbiotic Microbiome Complex Pathogenesis Intestinal Tight Junctions Gut Barrier Permeability Epithelial Cell Death Microbial Dysbiosis Dysregulated Inflammation Animal Models Cell Lines Intestinal Organoids In Vitro Model Microfluidic Technology NEC-on-a-chip Preterm Neonate Human Endothelial Cells Drug Discovery Testing
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