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Nephrotoxin Mikroinjektion i zebrafisk til model akut nyreskade

Article DOI: 10.3791/54241-v • 07:58 min • July 17th, 2016
July 17th, 2016 •
1,2, 1,2
1Center for Zebrafish Research, Department of Biological Sciences, University of Notre Dame, 2Center for Stem Cells and Regenerative Medicine, Department of Biological Sciences, University of Notre Dame

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Nyreskader afholdt fra nefrotoksiner, som omfatter lægemidler, der spænder fra antibiotika til kemoterapeutika, kan resultere i komplekse sygdomme, hvis patogenese forbliver ufuldstændigt forstået. Denne protokol viser, hvordan zebrafisk kan anvendes til sygdom modellering af disse forhold, som kan anvendes til identifikation af renoprotective foranstaltninger.

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Medicin zebrafisk nyre nephrotoxin renal clearance akut nyreskade mikroinjektion gentamicin
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