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Developmental Biology

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JoVE Journal Developmental Biology
Schnelle Erkennung von Entwicklungsstörungen Phänotypen in menschlichen neuronalen Vorläuferzellen (NPCs)
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Schnelle Erkennung von Entwicklungsstörungen Phänotypen in menschlichen neuronalen Vorläuferzellen (NPCs)

Article DOI: 10.3791/56628-v • 10:47 min • March 2nd, 2018
March 2nd, 2018 •
*1, *1, 1, 2, 3, 3, 4, 5, 2, 1
1Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, 2Center for Advanced Biotechnology and Medicine, Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, 3The Child Health Institute of NJ, Department of Obstetrics, Gynecology, and Reproductive Services, Rutgers Robert Wood Johnson Medical School, 4The Child Health Institute of NJ, Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, 5Department of Genetics, Rutgers University
* These authors contributed equally

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Neurodevelopmental Prozesse wie Proliferation, Migration und Neurit Auswuchs bei neuropsychiatrischen Erkrankungen oft gestört sind. So präsentieren wir Protokolle, um schnell und reproduzierbar Diese Entwicklungsstörungen Prozesse im menschlichen iPSC-abgeleitete NPCs zu beurteilen. Diese Protokolle ermöglichen auch die Bewertung der Auswirkungen der relevanten Wachstumsfaktoren und Therapeutika auf NPC-Entwicklung.

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Entwicklungsbiologie Ausgabe 133 Neurodevelopment Entwicklungsbiologie neurale Vorläuferzellen iPSC Erkrankung des Gehirns Autismus Wachstumsfaktoren Verbreitung Neurit Auswuchs Zellwanderung
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