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Developmental Biology

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JoVE Journal Developmental Biology
Hurtig påvisning af udviklingsforstyrrelser fænotyper i menneskelige neurale forløber celler (NPC)
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Hurtig påvisning af udviklingsforstyrrelser fænotyper i menneskelige neurale forløber celler (NPC)

Article DOI: 10.3791/56628-v • 10:47 min • March 2nd, 2018
March 2nd, 2018 •
*1, *1, 1, 2, 3, 3, 4, 5, 2, 1
1Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, 2Center for Advanced Biotechnology and Medicine, Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, 3The Child Health Institute of NJ, Department of Obstetrics, Gynecology, and Reproductive Services, Rutgers Robert Wood Johnson Medical School, 4The Child Health Institute of NJ, Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, 5Department of Genetics, Rutgers University
* These authors contributed equally

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Neuro-udviklingsmæssige processer såsom spredning, migration og neurite udvækst er ofte desorienterede i neuropsykiatriske sygdomme. Dermed, vi præsenterer protokoller for at hurtigt og reproducerbar vurdere disse Neuro-udviklingsmæssige processer i menneskelig iPSC-afledte NPCs. Disse protokoller tillader også vurdering af virkningerne af relevante vækstfaktorer og therapeutics på NPC udvikling.

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Udviklingsmæssige biologi sag 133 forstyrrelser i nervesystemets udvikling udviklingsmæssige biologi neurale forløber celler iPSC hjernesygdom autisme vækstfaktorer spredning neurite udvækst celle migration
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