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Journal / Biochemistry / Human perifert blod Neutrophil Isolering för…
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Biochemistry
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JoVE Journal Biochemistry
Human perifert blod Neutrophil Isolering för förhör av Parkinsons associerade LRRK2 Kinas väg genom att bedöma Rab10 Fosforylering
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Journal (Biochemistry)
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Human perifert blod Neutrophil Isolering för förhör av Parkinsons associerade LRRK2 Kinas väg genom att bedöma Rab10 Fosforylering

Article DOI: 10.3791/58956-v • 12:49 min • March 21st, 2020
March 21st, 2020 •
*1, *1, 2, 2, 2, 3, 4, 5, 1, 1,6
1MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, 2The Michael J. Fox Foundation for Parkinson's Research, 3Department of Medical and Molecular Genetics, Indiana University School of Medicine, 4Morton and Gloria Shulman Movement Disorders Centre and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, University of Toronto, 5Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, 6Division of Molecular and Clinical Medicine, School of Medicine, Ninewells Hospital and Medical School, University of Dundee
* These authors contributed equally

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Mutationer i leucin rika upprepa kinas 2 genen (LRRK2) orsaka ärftliga Parkinsons sjukdom. Vi har utvecklat en enkel och robust metod för bedömning av LRRK2-kontrollerad fosforylering av Rab10 i humana perifera blodnetrofiler. Detta kan hjälpa till att identifiera individer med ökad LRRK2 kinas utbildningsavsnitt aktivitet.

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Biokemi Nummer 157 Parkinsons sjukdom biomarkörer LRRK2-kinas perifera blodnetrofiler Rabproteiner vesikelhandel proteinfosforylering
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