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Manejo avanzado del ritmo cardíaco mediante la aplicación de fotoestimulación optogenética multisitio en corazones murinos
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Manejo avanzado del ritmo cardíaco mediante la aplicación de fotoestimulación optogenética multisitio en corazones murinos

Article DOI: 10.3791/62335-v • 08:43 min • August 26th, 2021
August 26th, 2021 •
*1,2, *1, 8,9, 1,3,4,6, 8,9, 1,5,6,7
1Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, 2Research Electronics Department, Max Planck Institute for Dynamics and Self-Organization, 3Department of Pharmacology and Toxicology, University Medical Center Goettingen, 4Institute for Nonlinear Dynamics, Georg-August-University Goettingen, 5Department of Cardiology and Pneumology, University Medical Center Goettingen, 6German Center for Cardiovascular Research, DZHK e.V., partner site Goettingen, 7Laboratory Animal Science Unit, German Primate Center Leibniz Institute for Primate Research, 8Department of Microsystems Engineering (IMTEK), University of Freiburg, 9Cluster of Excellence BrainLinks-BrainTools, University of Freiburg
* These authors contributed equally

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Este trabajo informa un método para controlar el ritmo cardíaco de corazones murinos intactos de ratones transgénicos con canalrodopsina-2 (ChR2) utilizando fotoestimulación local con una matriz de micro-LED y mapeo óptico simultáneo del potencial de la membrana epicárdica.

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Medicina Número 174 optogenética cardíaca mapeo óptico LED DI-4-ANBDQPQ Blebbistatin canalrodopsina-2 ChR2
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