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Ortopisk implantation af patientafledte kræftceller hos mus rekapitulerer avanceret kolorektal cancer
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Ortopisk implantation af patientafledte kræftceller hos mus rekapitulerer avanceret kolorektal cancer

Article DOI: 10.3791/64629-v • 06:49 min • February 10th, 2023
February 10th, 2023 •
1, 1, 2, 1,3
1Stem Cells and Cancer Laboratory, Vall d’Hebron Institute of Oncology (VHIO), 2Preclinical Therapeutics Core, University of California San Francisco, 3CIBERONC

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Denne protokol beskriver den ortopiske implantation af patientafledte kræftceller i cecumvæggen hos immundefekte mus. Modellen rekapitulerer avanceret kolorektal cancer metastatisk sygdom og giver mulighed for evaluering af nye terapeutiske lægemidler i et klinisk relevant scenario af lunge- og levermetastaser.

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Ortopisk implantation patientafledte kræftceller mus avanceret kolorektal cancer prækliniske modeller 3D-tumoroider tumororganoider screening af kræftmedicin lægemiddelresistensmekanismer metastatisk sygdom kræftbehandlinger in vivo-modeller molekylære træk human kræftmetastase ortopisk model cecumvæginjektion primære tumorer levermetastase lungemetastase CRC-musemodel lægemiddelresponser mikrocomputertomografi (ÂμCT) kirurgisk procedure immunodeficiente mus mus
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