La Red de Evaluación Preclínica del Ictus Modelo Multilaboratorio del Ictus Tromboembólico con Trombolisis: TE-MCAo

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06:38 min.

19 de diciembre de 2025

932 visualizaciones

¹Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine of USC, ²Department of Neurosurgery, Keck School of Medicine of USC, ³Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, ⁴Department of Internal Medicine, Division of Hematology, Oncology and Blood & Marrow Transplantation, Carver College of Medicine, University of Iowa, ⁵Departments of Neurology & Neurosurgery, Carver College of Medicine, Department of Epidemiology, College of Public Health, University of Iowa, ⁶The Medical College of Georgia at Augusta University, ⁷Department of Anesthesiology, Duke University, ⁸University of California, San Diego, ⁹Department of Neurology, Yale University, ¹⁰Neurovascular Research Unit, Massachusetts General Hospital, ¹¹Laboratory of NeuroImaging, USC Mark and Mary Stevens Neuroimaging and Informatics Institute of the Keck School of Medicine of USC, ¹²Department of Neurology, Keck School of Medicine of USC

Para simular el ictus tromboembólico, se inyectaron émbolos preparados a partir de sangre heteróloga de rata en la arteria cerebral media, seguidos de la administración de trombólisis sistémica para recanalización. Esta versión del modelo está optimizada para su uso en una red multilaboratorio y soporta la prueba de múltiples terapéuticas candidatas.