Spontaneous Pain
Spontaneous Pain - Related Videos
08:03
Spontaneous and Evoked Measures of Pain in Murine Models of Monoarticular Knee Pain
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Cited by 5 •
2019
We have developed an evoked measure of arthritis pain and coupled it with a standardized method for measuring spontaneous pain in different murine models of chemically induced arthritis. These measures are sensitive and reproducible for different types of joint pain.
02:21
Spontaneity
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2020
A spontaneous process is one that occurs naturally under certain conditions. A nonspontaneous process, on the other hand, will not take place unless it is “driven” by the continual input of energy from an external source. Processes have a natural tendency to occur in one direction under a given set of conditions. Water will naturally flow downhill (spontaneous process), but uphill flow (nonspontaneous process) requires outside intervention such as the use of a pump. Iron exposed to the earth’s...
10:39
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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Cited by 14 •
2014
In this study, the authors report for the first time a novel 3D-Immersive & Interactive Neuronavigation (3D-IIN) through the impact of a spontaneous migraine headache attack in the μ-opioid system of a patient's brain in vivo.
10:52
Chronic Constriction Injury of the Rat's Infraorbital Nerve (IoN-CCI) to Study Trigeminal Neuropathic Pain
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Cited by 45 •
2015
This manuscript describes a rodent model to study trigeminal neuropathic pain. The methods described include surgical procedures to perform a chronic constriction injury of the rat’s infraorbital nerve and the post-surgical behavioral tests to measure the changes in spontaneous and evoked behavior that are indicative of persistent pain and allodynia.
14:56
An Experimental Paradigm for the Prediction of Post-Operative Pain (PPOP)
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Cited by 107 •
2010
Diffuse noxious inhibitory control, temporal summation and wound hyperalgesia testing are demonstrated in the obstetric patient. These tests evaluate inhibitory and excitatory mechanisms of pain processing and are here utilized to evaluate endogenous analgesia at different time-points during pregnancy and the peripartum period to help reveal individual s risk for persistent pain.
FAQs
Persistent pain can be maintained by activity in sensitized nociceptors, the sensory receptors that detect potentially damaging conditions. Tissue injury or inflammation may leave these receptors more responsive, allowing them to signal without a new external trigger. This mechanism makes the symptom clinically informative because its presence can indicate continuing local pathology even when no provoking stimulus is apparent.
When nerves are damaged, they may generate abnormal electrical firing that produces spontaneous pain. This mechanism differs from pain driven mainly by inflamed tissue, where sensitized nociceptors are more central. The distinction matters because clinicians can use the symptom's quality, timing, and associated pattern to help separate neuropathic conditions from inflammatory ones during diagnostic assessment.
Enhanced processing in the spinal cord and brain can amplify incoming pain signals, so spontaneous pain may reflect altered central handling as well as activity at the injury site. This mechanism broadens interpretation: a patient's experience may persist even when peripheral tissue changes alone do not explain its intensity. Recognizing central contribution supports more precise investigation of nervous-system dysfunction.
Assessment focuses on when spontaneous pain occurs, how intense it becomes, and how the patient characterizes it. Timing can show whether symptoms are continuous or intermittent, while intensity provides a measure of severity and quality may help suggest inflammatory or neuropathic mechanisms. Clinicians use this structured description alongside broader clinical evaluation to guide diagnosis and subsequent management.
Spontaneous pain can reveal treatment effects that experimentally evoked pain fails to show. Because it reflects ongoing disease-related signaling rather than only a response to a controlled stimulus, measuring it adds clinically relevant information about symptom relief. Trial investigators can therefore use it to evaluate candidate analgesics under conditions closer to patients' ongoing experience.
Changes in this symptom can indicate whether a treatment affects ongoing nociceptor activity, abnormal nerve firing, or enhanced pain processing. Its measurement helps connect a therapy's effect with the underlying pain mechanism and can inform development of more targeted analgesics. In practice, that information may also strengthen individualized pain-management strategies.