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Immunology and Infection

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JoVE Journal Immunology and Infection
HLA - IG基于人工抗原提呈细胞可高效体外扩展人类的CTL
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HLA - IG基于人工抗原提呈细胞可高效体外扩展人类的CTL

Article DOI: 10.3791/2801-v • 07:19 min • April 11th, 2011
April 11th, 2011 •
1,2, 3,4, 3,4
1Immunology Graduate Program, Johns Hopkins University, 2Department of Internal Medicine, Far-Eastern Memorial Hospital, 3Department of Pathology, Johns Hopkins University, 4Institute of Cell Engineering, Johns Hopkins University

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描述一个新的DC抗原特异性T细胞的诱导和扩张的独立方法。基于HLA A2 - Ig的人工抗原提呈细胞（AAPC）加载与HLA - A2限制性肽能够有效地扩大多样化的抗原特异性CTL的。该技术拥有CTL为基础的过继免疫治疗的巨大潜力。

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免疫学杂志，50期，免疫治疗，收养治疗T细胞，CD8 +的T细胞，HLA - A2免疫球蛋白，巨细胞病毒，AAPC，直流
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