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Development of Recombinant Proteins to Treat Chronic Pain
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Development of Recombinant Proteins to Treat Chronic Pain

Article DOI: 10.3791/57071-v • 10:37 min • April 11th, 2018
April 11th, 2018 •
1, 2, 1, 1, 1, 1,3
1Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, 2Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht University, 3Laboratory of Neuroimmunology and Developmental Origins of Disease, University Medical Center Utrecht, Utrecht University

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In this paper we provide details for the methods of production and quality control of an IL4-10 recombinant fusion protein. We also show how to test the effectiveness of this protein to resolve pain in a mouse model of inflammatory pain.

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Recombinant Proteins Chronic Pain Treatment Fusion Protein Anti-inflammatory Cytokines IL4 IL10 Analgesic Properties Chronic Inflammatory Pain Models Biologics Development Quality Control Functional Activity Evaluation Therapeutic Potential Behavioral Tests Inflammatory Diseases HEK 293F Cells DNA Transfection Reagent Mixture Culture Supernatant
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