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Bioengineering

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JoVE Journal Bioengineering
用化学表观修饰因子重定向细胞机械抑制基因转录
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用化学表观修饰因子重定向细胞机械抑制基因转录

Article DOI: 10.3791/58222-v • 10:28 min • September 20th, 2018
September 20th, 2018 •
1, 2, 3, 3, 4
1Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, Curriculum in Genetics and Molecular Biology, University of North Carolina, 2College of Arts and Sciences, Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, University of North Carolina, 3Chemical Biology and Drug Discovery, Pharmacological Sciences and Oncological Sciences, Icahn School of Medicine at Mount Sinai, 4Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, Curriculum in Genetics and Molecular Biology, Lineberger Comprehensive Cancer Center, University of North Carolina

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对染色质环境的调节是正确基因表达所需的必要过程。在这里, 我们描述了一种方法来控制基因表达, 通过招募的染色质修改机制, 基因特异和可逆的方式。

Tags

生物工程 问题 139 化学生物学 双分子 化学诱导接近度 染色质调节 基因抑制 组蛋白乙酰 表观遗传学 化学后生修饰语 CEMs
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