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Genetics

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JoVE Journal Genetics

التحقيق في التسبب في طفرة MYH7 Gly823Glu في اعتلال عضلة القلب الضخامي العائلي باستخدام نموذج الماوس

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images

Journal (Genetics)

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images

Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models

Journal (Genetics)

Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models

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التحقيق في التسبب في طفرة MYH7 Gly823Glu في اعتلال عضلة القلب الضخامي العائلي باستخدام نموذج الماوس

Article DOI: 10.3791/63949-v • 03:45 min • August 8th, 2022

August 8th, 2022 •

Yu Xia*^1,2, Jinlin Hu*³, Xiang Li⁴, Shuang Zheng⁴, Ge Wang^1,2, Songtao Tan^1,2, Zengxiao Zou^1,2, Qiong Ling^2,5, Fenghua Yang⁴, Xiaoping Fan^1,2

¹Department of Cardiovascular Surgery, Guangdong Provincial Hospital of Traditional Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, ²The Second Clinical College of Guangzhou University of Chinese Medicine, ³Department of Cardiovascular Surgery, The First Affiliated Hospital, Jinan University, ⁴Guangdong Provincial Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, ⁵Department of Anesthesiology, Guangdong Provincial Hospital of Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine

* These authors contributed equally

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استنادا إلى عائلة اعتلال عضلة القلب الوراثي العائلي الموجودة في عملنا السريري ، أنشأنا نموذج فأر C57BL / 6N مع طفرة نقطية (G823E) في موضع الفأر MYH7 من خلال هندسة الجينوم بوساطة CRISPR / Cas9 للتحقق من هذه الطفرة.

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