Spray Dried Powders
Spray Dried Powders - Related Videos
07:55
Intratracheal Administration of Dry Powder Formulation in Mice
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Cited by 20 •
2020
Dry powder formulations for inhalation have great potential in treating respiratory diseases. Before entering human studies, it is necessary to evaluate the efficacy of the dry powder formulation in preclinical studies. A simple and noninvasive method of the administration of dry powder in mice through the intratracheal route is presented.
07:28
Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
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Cited by 11 •
2017
The inhalation unit described herein can generate, sample for characterization, and uniformly deposit a drug aerosol in the lungs of rodents. This enables the pre-clinical determination of the efficacy and safety of drug doses deposited in the lungs; key data enabling clinical inhaled drug development.
04:59
Disposable Dosators Intended for Dry Powder Delivery to Mice
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Cited by 2 •
2023
Pharmaceutical dry powder development necessitates reliable in vivo testing, often using a murine model. Device technology for accurately and reproducibly delivering dry powder aerosols to mice is restricted. This study presents disposable dosators for pulmonary drug delivery at mouse-relevant doses, aiding initial proof-of-concept research.
05:45
Process Development for the Spray-Drying of Probiotic Bacteria and Evaluation of the Product Quality
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Cited by 7 •
2023
This protocol details the steps involved in the production and physicochemical characterization of a spray-dried probiotic product.
12:00
Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro
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Cited by 9 •
2017
This work details a step-by-step method to prepare polyphenol-rich extracts from freeze-dried berry powder. In addition, it provides a thorough description of how to use these polyphenol-rich extracts in cell culture in the presence of the peptide hormone angiotensin II (Ang II) using Vascular Smooth Muscle Cells (VSMCs).
FAQs
Feed properties and drying conditions help determine the resulting particles’ size, morphology, and composition. The liquid may contain a drug in solution or suspension, while atomization creates fine droplets that dry rapidly in a heated gas stream. Adjusting these inputs changes the physical form of the powder, which can affect its handling and performance in pharmaceutical formulations.
Rapid evaporation converts dispersed liquid droplets into solid particles during their passage through the heated gas stream. This short drying process supports formation of a dry, flowable material rather than leaving the drug in a liquid formulation. The resulting solid form can make active ingredients easier to handle and incorporate into dosage forms.
Excipients are added to support specific formulation properties rather than simply to provide bulk. Depending on the formulation, they can improve powder dispersibility, promote dissolution, or help maintain shelf life. Their inclusion is especially relevant when the active ingredient must be converted into an inhalable powder, oral dosage form, or stabilized pharmaceutical preparation.
A drug solution or suspension is first prepared as the liquid feed. That feed is then atomized into fine droplets and introduced into a heated gas stream, where the solvent evaporates rapidly. The remaining solid particles are collected as a dry powder. Feed composition and drying conditions are selected according to the desired particle characteristics.
This approach is useful when a medicine needs a practical solid form for administration or storage. Pharmaceutical developers can use the resulting powder in inhalable products, oral dosage forms, or stabilized formulations. The method is also relevant when improving dispersibility, dissolution, shelf life, handling, or the potential bioavailability of an active ingredient.
In medicine, these powders can support precise delivery by converting active ingredients into forms suited to particular dosage routes. Their particle properties and excipient composition may influence dispersibility and dissolution, while the dry format can improve handling and contribute to formulation stability. Together, these features may support enhanced bioavailability and more practical pharmaceutical products.