Biocompatible Sensors
Biocompatible Sensors - Related Videos
03:47
Implantation of a Flexible Biocompatible Probe in a Glioblastoma Mouse Model
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2025
Source: Lefevre, M. C., et al., Flexible Organic Electronic Devices for Pulsed Electric Field Therapy of Glioblastoma. J. Vis. Exp. (2022)This video demonstrates the implantation of a flexible, biocompatible probe in a glioblastoma mouse model to deliver targeted pulsed electric field therapy for neurotherapeutic applications.
09:14
Glovebox and Impurity Sensors
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2023
Source: Tamara M. Powers, Department of Chemistry, Texas A&M University The glovebox provides a straightforward means to handle air- and moisture-sensitive solids and liquids. The glovebox is what it sounds like: a box with gloves attached to one or more sides, which allows the user to perform manipulations within the glovebox under an inert atmosphere. For manipulations under inert atmospheres, chemists can choose between Schlenk or high-vacuum techniques and a glovebox. Schlenk and...
09:30
Bacterial Detection & Identification Using Electrochemical Sensors
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Cited by 6 •
2013
We describe an electrochemical sensor assay method for rapid bacterial detection and identification. The assay involves a sensor array functionalized with DNA oligonucleotide capture probes for ribosomal RNA (rRNA) species-specific sequences. Sandwich hybridization of target rRNA with the capture probe and a horseradish peroxidase-linked DNA oligonucleotide detector probe produces a measurable amperometric current.
10:23
Glutamine Flux Imaging Using Genetically Encoded Sensors
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Cited by 7 •
2014
This article will demonstrate how to monitor glutamine dynamics in live cells using FRET. Genetically encoded sensors allow real-time monitoring of biological molecules at a subcellular resolution. Experimental design, technical details of the experimental settings, and considerations for post-experimental analyses will be discussed for genetically encoded glutamine sensors.
05:15
An Aptamer-based Sensor for Unchelated Gadolinium(III)
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2017
The use of polydeoxynucleotide (44-mer aptamer) molecules for sensing unchelated gadolinium(III) ion in an aqueous solution is described. The presence of the ion is detected via an increase in the fluorescence emission of the sensor.
FAQs
A sensing material responds to a biological, chemical, or physical event, such as molecular binding, an ion concentration change, strain, or temperature variation. A transduction mechanism then converts that response into an electrical, optical, or mechanical signal. This conversion allows measurements from living tissues or body fluids to be recorded and analyzed rather than observed only indirectly.
Biocompatibility helps the device function in contact with tissues or body fluids while minimizing adverse immune or toxic responses. This compatibility matters because unwanted biological reactions could interfere with the sensing environment or limit continued use. In bioengineering, considering these responses is therefore part of connecting reliable signal measurement with appropriate interaction at the tissue interface.
The target signal determines both the sensing material and the transduction approach. Molecular binding and ion concentration changes represent chemical or biological inputs, whereas strain and temperature variation represent physical inputs. Because these events differ in nature, a sensor must pair its sensing component with a suitable electrical, optical, or mechanical method for producing a measurable output.
Continuous measurements can reveal changes over time, while localized measurements provide information from a specific tissue, body-fluid environment, or interface. Together, these capabilities support closer monitoring than a single isolated observation. In bioengineering applications, the resulting information can contribute to disease monitoring, therapy guidance, and studies of how engineered systems interact with living tissues.
A development workflow begins by identifying the biological, chemical, or physical signal of interest. Researchers then select sensing materials and a transduction mechanism that can convert that event into a measurable output. The system must also be considered in relation to contact with living tissues or body fluids, including the need to minimize immune or toxic responses during its intended use.
Major application settings include wearable health monitors, implantable devices, point-of-care diagnostics, and tissue-interface studies. These settings differ in how the sensor contacts the body and how measurements are obtained, but each benefits from sensing biological or physical changes in a relevant environment. The same general technology therefore supports both practical monitoring and investigation of tissue interactions.
By providing continuous, localized measurements, biocompatible sensing systems can supply information about changing biological conditions rather than only a single endpoint. That information may help monitor disease, guide therapies, and support more individualized care. In regenerative research, tissue-interface measurements can help investigators study interactions involving engineered systems and living tissues, linking sensor data with biological development.