Vh Ivus Images
Vh Ivus Images - Related Videos
09:43
In vivo Near Infrared Fluorescence (NIRF) Intravascular Molecular Imaging of Inflammatory Plaque, a Multimodal Approach to Imaging of Atherosclerosis
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Cited by 32 •
2011
We detail a new near-infrared fluorescence (NIRF) catheter for 2-dimensional intravascular molecular imaging of plaque biology in vivo. The NIRF catheter can visualize key biological processes such as inflammation by reporting on the presence of plaque-avid activatable and targeted NIR fluorochromes. The catheter utilizes clinical engineering and power requirements and is targeted for application in human coronary arteries. The following research study describes a multimodal imaging strategy...
05:06
Bioluminescent Bacterial Imaging In Vivo
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Cited by 9 •
2012
This article describes the administration of lux-tagged bacteria to mice and subsequent in vivo analysis using IVIS bioluminescence imaging.
12:38
4D Multimodality Imaging of Citrobacter rodentium Infections in Mice
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Cited by 19 •
2013
Multi-modality imaging is a valuable approach for studying bacterial colonization in small animal models. This protocol outlines infection of mice with bioluminescent Citrobacter rodentium and the longitudinal monitoring of bacterial colonization using composite 3D diffuse light imaging tomography with μCT imaging to create a 4D movie of C. rodentium infection.
07:33
In vivo Dual Substrate Bioluminescent Imaging
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Cited by 20 •
2011
Herein we describe the methods to construct, visualize, and quantify the bioluminescent reactions of both firefly and renilla luciferase enzymes expressed in metastatic breast cancer cells during their growth and metastasis in vivo.
06:39
Bioluminescence Imaging of Heme Oxygenase-1 Upregulation in the Gua Sha Procedure
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Cited by 40 •
2009
Gua Sha, traditional Chinese therapeutic skin scraping, causes subcutaneous microvascular blood extravasation. We report a protocol of bioluminescence imaging of HO-1-luciferase transgenic mice to demonstrate that Gua Sha upregulates heme oxygenase-1 (HO-1) in multiple organs.
FAQs
The system analyzes the radiofrequency patterns contained in returning ultrasound echoes rather than relying only on visible vessel morphology. Differences in backscatter allow the image analysis to classify plaque-related tissue components, including fibrous tissue, lipid-rich regions, and calcium. This adds compositional information that supports more detailed lesion characterization than measurements based solely on vessel size or shape.
Conventional ultrasound imaging primarily depicts vessel dimensions and morphology, whereas VH-IVUS analysis extends that assessment to plaque composition. The additional interpretation of radiofrequency backscatter helps distinguish tissue categories within a lesion. For engineering studies, this distinction provides both structural and compositional measurements, enabling researchers to evaluate arterial abnormalities with greater specificity than morphology alone.
VH-IVUS images classify tissue components such as fibrous tissue, lipid-rich regions, and calcium. Separating these categories helps researchers describe what a lesion contains, not merely where it is located or how large it appears. That information supports quantitative plaque assessment and lesion characterization, giving cardiovascular and engineering studies a more detailed basis for comparing vascular findings.
Connecting quantitative image measurements to vascular structure allows investigators to interpret plaque composition within the physical context of the artery. This relationship supports analysis of lesion characteristics and disease progression while also informing the evaluation of intravascular imaging systems. In engineering, the combined structural and compositional view can guide assessment of imaging performance and device-related interventions.
A catheter-mounted transducer is positioned inside the vessel and emits high-frequency sound waves. The system records the returning echoes, processes their radiofrequency backscatter patterns, and uses those patterns to classify plaque-related tissue components. Researchers can then derive quantitative information about plaque and relate it to vessel structure for lesion assessment or engineering analysis.
These images are used for quantitative plaque assessment, lesion characterization, and studies of disease progression. They also support device design and evaluation of stent placement by providing information about vascular structure and plaque composition. Consequently, engineers can use the image-derived findings to study how intravascular imaging systems perform and to assess device-related outcomes within the vessel.