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Cancer Research

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Modeling osteosarkom med Li-Fraumeni syndrom patientderiverade inducerade pluripotenta stamceller

Article DOI: 10.3791/57664-v • 08:52 min • June 13th, 2018
June 13th, 2018 •
1,2, 1, 1,3, 1, 4, 1, 1,2,5,6
1Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, 2Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center UTHealth, 3Department of Musculoskeletal Oncology, The First Affiliated Hospital of Sun Yat-sen University, 4Women's Health Institute, Cleveland Clinic Foundation, 5Center for Stem Cell and Regenerative Medicine, The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center at Houston, 6Center for Precision Health, School of Biomedical Informatics and School of Public Health, The University of Texas Health Science Center at Houston

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Här presenterar vi ett protokoll för generering av inducerade pluripotenta stamceller (iPSCs) från Li-Fraumeni syndrom (AKU) patientens härledda fibroblaster, differentiering av iPSCs via mesenkymala stamceller (MSC) till osteoblaster, och modellering i vivo tumourigenesis med LFS patientderiverade osteoblaster.

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Cancerforskning fråga 136 iPSCs Li-Fraumeni syndrom omprogrammering differentiering mesenkymala stamceller osteoblaster osteosarkom xenograft
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