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En rotte halspulsåren Tryk-kontrolleret segmental ballon skade med Periadventitial Terapeutisk Application

Article DOI: 10.3791/60473-v • 06:53 min • July 9th, 2020
July 9th, 2020 •
1,2,3,5, 1,2,3,4,5
1Department of Surgery, Division of Vascular Surgery, University of North Carolina at Chapel Hill, 2Center for Nanotechnology in Drug Delivery, University of North Carolina at Chapel Hill, 3Curriculum in Toxicology & Environmental Medicine, University of North Carolina at Chapel Hill, 4Department of Cell Biology & Physiology, University of North Carolina at Chapel Hill, 5McAllister Heart Institute, University of North Carolina at Chapel Hill

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Den rotte halspulsåren ballon skade efterligner den kliniske angioplastik procedure, der udføres for at genoprette blodgennemstrømningen i aterosklerotiske fartøjer. Denne model fremkalder arteriel skade respons ved distending arteriel væg, og benægte intimal lag af endotelceller, i sidste ende forårsager remodeling og en intimal hyperplastisk reaktion.

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Medicin Rat Halspulsåren Ballon Skade Vaskulær skade Restenosis Neointimal Hyperplasia Periadventitial Drug Delivery Arteriel Skade Response Vessel Remodeling hjerte-kar-sygdomme perifer arteriesygdom vaskulær glat muskelcelle lys ark fluorescerende mikroskopi
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