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Journal / Biology / Meten RAN Peptide Toxiciteit in C. elegans
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Meten RAN Peptide Toxiciteit in C. elegans

Article DOI: 10.3791/61024-v • 10:49 min • April 30th, 2020
April 30th, 2020 •
1, 2, 2, 1,2
1Graduate Program in Cell Biology and Molecular Physiology, University of Pittsburgh, 2Department of Pediatrics, University of Pittsburgh School of Medicine

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Herhaal-geassocieerde niet-ATG-afhankelijke translationele producten zijn opkomende pathogene kenmerken van verschillende herhaalde expansie-gebaseerde ziekten. Het doel van het beschreven protocol is om toxiciteit veroorzaakt door deze peptiden te evalueren met behulp van gedrags-en cellulaire testen in het modelsysteem C. elegans.

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Biologie Nummer 158 neurodegeneratie ALS ZvH C9orf72 proteotoxiciteit herhaalde expansiestoornissen
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