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JoVE Journal Medicine
Avanceret hjerterytmestyring ved anvendelse af optogenetisk multi-site fotostimulation i Murine Hearts
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Avanceret hjerterytmestyring ved anvendelse af optogenetisk multi-site fotostimulation i Murine Hearts

Article DOI: 10.3791/62335-v • 08:43 min • August 26th, 2021
August 26th, 2021 •
*1,2, *1, 8,9, 1,3,4,6, 8,9, 1,5,6,7
1Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, 2Research Electronics Department, Max Planck Institute for Dynamics and Self-Organization, 3Department of Pharmacology and Toxicology, University Medical Center Goettingen, 4Institute for Nonlinear Dynamics, Georg-August-University Goettingen, 5Department of Cardiology and Pneumology, University Medical Center Goettingen, 6German Center for Cardiovascular Research, DZHK e.V., partner site Goettingen, 7Laboratory Animal Science Unit, German Primate Center Leibniz Institute for Primate Research, 8Department of Microsystems Engineering (IMTEK), University of Freiburg, 9Cluster of Excellence BrainLinks-BrainTools, University of Freiburg
* These authors contributed equally

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Dette arbejde rapporterer en metode til styring af hjerterytmen hos intakte murinhjerter hos transgene channelrhodopsin-2 (ChR2) mus ved hjælp af lokal fotostimulation med et mikro-LED-array og samtidig optisk kortlægning af epikardiemembranpotentiale.

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Medicin udgave 174 hjerteoptogenetik optisk kortlægning LED DI-4-ANBDQPQ Blebbistatin channelrhodopsin-2 ChR2
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