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Multipel intravenøs bolusdosering og invasiv hæmodynamisk vurdering i en hypoxi-induceret musepulmonal arteriehypertensionsmodel
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Multipel intravenøs bolusdosering og invasiv hæmodynamisk vurdering i en hypoxi-induceret musepulmonal arteriehypertensionsmodel

Article DOI: 10.3791/63839-v • 08:51 min • November 11th, 2022
November 11th, 2022 •
1, 2, 3, 3, 4,5, 4
1Department of Surgery, Yale University School of Medicine, 2Department of Vascular Surgery, The First Hospital of China Medical University, Key Laboratory of Pathogenesis, Prevention, and Therapeutics of Aortic Aneurysm, 3VasoRx Inc., 4Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, 5Department of Cell Biology, Yale University School of Medicine

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Denne protokol giver en trinvis procedure til udførelse af flere intravenøse bolusdoser og invasiv hæmodynamisk overvågning hos mus. Efterforskere kan bruge denne protokol til fremtidig terapeutisk sammensat screening for pulmonal arteriehypertension.

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Intravenøs bolusdosering invasiv hæmodynamisk vurdering hypoxi-induceret musepulmonal arteriehypertensionsmodel pulmonal arteriel hypertension PAH-forskning eksperimentelle terapier halsvene med mus arteriel kateterisering kateterisering af højre ventrikel PAH-model
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