JoVE Journal

Medicine

JoVE Medicine includes methods and experimental approaches for biomedical research and clinical medicine, including case studies, clinical procedures, surgeries, clinical trials, and animal models of disease.

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Assessing Neuroprotective Effects of Glycyrrhizae Radix et Rhizoma Extract Using a Transient Middle Cerebral Artery Occlusion Mouse Model

Se-Eun Lee*¹, Chiyeon Lim*², Minji Lee¹, Chang-Hyun Kim², Hyungwoo Kim¹, Byoungho Lee³, Suin Cho¹

¹School of Korean Medicine, Pusan National University, ²College of Medicine, Dongguk University, ³Kyunghee Naseul Korean Medicine Clinic

A Pulmonary Trunk Banding Model of Pressure Overload Induced Right Ventricular Hypertrophy and Failure

Stine Andersen¹, Jacob Gammelgaard Schultz¹, Sarah Holmboe¹, Julie Birkmose Axelsen¹, Mona Sahlholdt Hansen¹, Mads Dam Lyhne¹, Jens Erik Nielsen-Kudsk¹, Asger Andersen¹

¹Department of Clinical Medicine and Cardiology, Aarhus University Hospital

Generating a Murine Orthotopic Metastatic Breast Cancer Model and Performing Murine Radical Mastectomy

Eriko Katsuta¹, Masanori Oshi¹, Omar M. Rashid^2,3,4,5, Kazuaki Takabe^1,6,7,8,9,10

¹Breast Surgery, Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, ²Holy Cross Hospital Michael and Dianne Bienes Comprehensive Cancer Center, ³Department of Surgery, Massachusetts General Hospital, ⁴Department of Surgery, University of Miami Miller School of Medicine, ⁵Department of Surgery, Nova Southeastern University School of Medicine, ⁶Department of Surgery, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, ⁷Department of Breast Surgery and Oncology, Tokyo Medical University, ⁸Department of Surgery, Yokohama City University, ⁹Department of Surgery, Niigata University Graduate School of Medical and Dental Sciences, ¹⁰Department of Surgery, Fukushima Medical University

2D and 3D Echocardiography in the Axolotl (Ambystoma Mexicanum)

Anita Dittrich¹, Mathias Møller Thygesen¹, Henrik Lauridsen¹

¹Department of Clinical Medicine, Aarhus University

Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery

Paul S. Pagel¹, Lonnie Dye III², Graham E.D. Hill², Juan L. Vega², Justin N. Tawil², Derek J. De Vry², Kiran Chandrashekarappa¹, Zafar Iqbal¹, Brent T. Boettcher¹, Julie K. Freed²

¹Anesthesia Service, Clement J. Zablocki Veterans Affairs Medical Center, ²Department of Anesthesiology, Medical College of Wisconsin

Invasive Hemodynamic Monitoring of Aortic and Pulmonary Artery Hemodynamics in a Large Animal Model of ARDS

Rahel Kluttig¹, Till Friedheim¹, Christoph Behem¹, Niko Zach¹, Rosannis Brown¹, Michael Graessler¹, Daniel Reuter¹, Christian Zöllner¹, Constantin Trepte¹

¹Universitatsklinikum Hamburg-Eppendorf

Left Atrial Stenosis Induced Pulmonary Venous Arterialization and Group 2 Pulmonary Hypertension in Rat

Ping Yu Xiong*^1,2, Shunsuke Baba*^3,4, Naritomo Nishioka^3,5, Yoshitaka Fujimoto³, Stephen L. Archer¹, Susumu Minamisawa^1,4

¹Department of Medicine, Queen's University, ²Department of Biomedical and Molecular Sciences, Queen's University, ³Department of Cell Physiology, The Jikei University School of Medicine, ⁴Department of Pediatrics, The Jikei University School of Medicine, ⁵Department of Cardiovascular Surgery, The Jikei University School of Medicine

Subclavian Vein Puncture As an Alternative Method of Blood Sample Collection in Rats

Hui Yang¹, Pu Zou¹, Jingyuan Chen¹, Gaoxing Shi¹, Chenlu Wu¹, Mi Wang¹, Qin Zhou², Shenghua Zhou¹

¹Department of Cardiology, The Second Xiangya Hospital, Central South University, ²Department of General Surgery, The Second Xiangya Hospital, Central South University

Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery

Takanori Kanazawa*¹, Mitsuyoshi Fukuda*¹, Naoto Suzuki¹, Toyofumi Suzuki¹

¹Laboratory of Pharmaceutics, School of Pharmacy, Nihon University

One-anastomosis Gastric Bypass (OAGB) in Rats

Matthieu A. Siebert¹, Jean-Marc Chevallier², Diego D'Aurelle de Paladines¹, Yohann Pottier¹, Simon Msika^1,3, Maude Le Gall¹, André Bado¹, Lara Ribeiro-Parenti^1,3

¹Institut national de la santé et de la recherche médicale (Inserm) unité mixte de recherche (UMR) 1149, Unité de formation et de recherche (UFR) de Médecine Paris Diderot, Universit é Paris Diderot, Assistance Publique-Hôpitaux de Paris (AP-HP), ²Department of digestive Surgery, AP-HP Hôpital Européen Georges Pompidou, ³Department of General and Visceral Surgery, Bichat-Claude Bernard University Hospital

Semi-quantitative Assessment Using [¹⁸F]FDG Tracer in Patients with Severe Brain Injury

Tomohiro Yamaki^1,2, Shinji Onodera², Tomoki Uchida², Yoshihiro Ozaki², Kazuaki Yokoyama³, Haruko Henmi², Mizuho Kamezawa², Miyoko Hayakawa², Daisuke Itou¹, Nobuo Oka^1,2, Masaru Odaki¹, Yasuo Iwadate⁴, Shigeki Kobayashi¹

¹Division of Neurosurgery, Rehabilitation Center for Traumatic Apallics Chiba, National Agency for Automotive Safety and Victims' Aid, ²Division of PET imaging, Rehabilitation Center for Traumatic Apallics Chiba, National Agency for Automotive Safety and Victims' Aid, ³Tokyo Nuclear Services Co. Ltd., ⁴Department of Neurological Surgery, Graduate School of Medicine, Chiba University

Using a Knee Arthrometer to Evaluate Tissue-specific Contributions to Knee Flexion Contracture in the Rat

T. Mark Campbell^1,2,3, Katherine Reilly^2,3, Louis Goudreau⁴, Odette Laneuville^2,5, Hans Uhthoff^2,3, Guy Trudel^2,3,4

¹Elizabeth Bruyère Hospital, ²The Bone and Joint Research Laboratory, University of Ottawa, ³Department of Medicine, University of Ottawa, ⁴The Ottawa Hospital Rehabilitation Centre, ⁵Department of Biology, University of Ottawa

Severe Burn Injury in a Swine Model for Clinical Dressing Assessment

Gang-Yi Fan¹, Juin-Hong Cherng^2,3, Shu-Jen Chang⁴, Raju Poongodi², Chih-Hsin Wang⁵, Yi-Wen Wang², Yao-Horng Wang⁶, Cheng-Che Liu⁷, En Meng⁸

¹Graduate Institute of Medical Sciences, National Defense Medical Center, ²Department and Graduate Institute of Biology and Anatomy, National Defense Medical Center, ³Department of Gerontological Health Care, National Taipei University of Nursing and Health Sciences, ⁴Division of Rheumatology/Immunology/Allergy, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, ⁵Department of Plastic and Reconstructive Surgery, Tri-Service General Hospital, ⁶Department of Nursing, Yuanpei University, ⁷Department of Physiology and Biophysics; Graduate Institute of Physiology, National Defense Medical Center, ⁸Division of Urology, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center

Lentiviral Vector-mediated Gene Therapy of Hepatocytes Ex Vivo for Autologous Transplantation in Swine

Robert A. Kaiser^1,2, Shennen A. Mao¹, Jaime Glorioso³, Bruce Amiot¹, Clara T. Nicolas¹, Kari L. Allen¹, Zeji Du¹, Caitlin J VanLith¹, Raymond D. Hickey¹, Scott L. Nyberg¹, Joseph B. Lillegard^1,2,4

¹Department of Surgery, Mayo Clinic, ²Midwest Fetal Care Center, Children's Hospitals and Clinics of Minnesota, ³Department of Surgery, Johns Hopkins, ⁴Pediatric Surgical Associates

Database-guided Flow-cytometry for Evaluation of Bone Marrow Myeloid Cell Maturation

Carmen Mariana Aanei¹, Marie-Christine Jacob², Richard Veyrat-Masson³, Tiphanie Picot¹, Maria Alessandra Rosenthal-Allieri⁴, Anne-Catherine Lhoumeau⁵, Michel Ticchioni⁴, Florent Dumezy⁶, Lydia Campos Catafal¹

¹Department of Hematology, University Hospital of Saint-Etienne, ²Department of Immunology, University Hospital of Grenoble-Alpes, ³Department Hematology, University Hospital of Clermont-Ferrand, ⁴Department of Immunology, University Hospital of Nice, ⁵Department of Biopathology, Institute Paoli-Calmettes, ⁶Department of Hematology, University Hospital of Lille

Ultrahigh Resolution Mouse Optical Coherence Tomography to Aid Intraocular Injection in Retinal Gene Therapy Research

Mark C. Butler^1,2, Jack M. Sullivan^{1,2,3,4,5,6,7}

¹Research Service, VA Western New York Healthcare System, ²Department of Ophthalmology, (Ross Eye Institute), Jacobs School of Medicine and Biomedical Sciences, University at Buffalo- SUNY, ³Pharmacology/Toxicology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo- SUNY, ⁴Physiology/Biophysics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo- SUNY, ⁵Neuroscience Program, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo- SUNY, ⁶The RNA Institute, University at Buffalo- SUNY, ⁷The SUNY Eye Institute

Three-Dimensional Printing of a Complex Aortic Anomaly

Xiaoning Sun^1,2, Kai Zhu^1,2, Weijia Zhang^1,2,3,4, Hongqiang Zhang^1,2, Fazong Hu⁵, Chunsheng Wang^1,2

¹Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, ²Shanghai Institute of Cardiovascular Disease, ³State Key Laboratory of Molecular Engineering of Polymers, Fudan University, ⁴Institutes of Biomedical Sciences, Fudan University, ⁵Meditool Shanghai Enterprise Co., Ltd.

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

Brittney M. Rush*¹, Sarah A Small*¹, Donna B. Stolz², Roderick J. Tan¹

¹Division of Renal-Electrolyte, Department of Medicine, University of Pittsburgh, ²Department of Cell Biology, University of Pittsburgh

Oleic Acid-Injection in Pigs As a Model for Acute Respiratory Distress Syndrome

Jens Kamuf¹, Andreas Garcia-Bardon¹, Alexander Ziebart¹, Rainer Thomas¹, Robert Rümmler¹, Christian Möllmann¹, Erik K. Hartmann¹

¹Department of Anesthesiology, University Medical Center of the Johannes Gutenberg-University

Veno-Venous Extracorporeal Membrane Oxygenation in a Mouse

Nodir Madrahimov¹, Abdurasul Khalikov¹, Erin C. Boyle¹, Ruslan Natanov¹, Ann-Kathrin Knoefel¹, Thierry Siemeni¹, Klaus Hoeffler¹, Axel Haverich¹, Ulrich Maus*², Christian Kuehn*¹

¹Department of Cardiothoracic, Transplantation, and Vascular Surgery, Hannover Medical School, ²Department of Pneumology, Hannover Medical School

In Vitro Method to Control Concentrations of Halogenated Gases in Cultured Alveolar Epithelial Cells

Raïko Blondonnet^1,2, Bertille Paquette^1,2, Damien Richard³, Rémi Bourg^2,4, Géraldine Laplace^2,4, Romain Segurel^2,4, Henria Pouvelle^2,4, Corinne Belville², Loic Blanchon², Thomas Godet^1,2, Jean-Michel Constantin^1,2, Jean-Etienne Bazin^1,2, Vincent Sapin², Matthieu Jabaudon^1,2

¹Department of Perioperative Medicine, CHU Clermont-Ferrand, ²Centre National de la Recherche Scientifique Unité Mixte de Recherche (CNRS UMR) 6293, Institut National de la Santé et de la Recherche Médicale (INSERM) U1103, Laboratoire de Génétique, Reproduction et Développement (GReD), Université Clermont Auvergne, ³Department of Pharmacology, CHU Clermont-Ferrand, ⁴Nurse Anesthetist School, CHU Clermont-Ferrand

Isolation of Primary Mouse Hepatocytes for Nascent Protein Synthesis Analysis by Non-radioactive L-azidohomoalanine Labeling Method

Esam S.B. Salem*^1,2, Kazutoshi Murakami*², Toshimasa Takahashi², Elise Bernhard², Vishnupriya Borra², Mridula Bethi², Takahisa Nakamura^2,3,4

¹Department of Pharmacology and Systems Physiology, College of Medicine, University of Cincinnati, ²Division of Endocrinology, Cincinnati Children's Hospital Medical Center, ³Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, ⁴Department of Pediatrics, College of Medicine, University of Cincinnati

Transdermal Measurement of Glomerular Filtration Rate in Mice

Lauren Scarfe^1,2, Daniel Schock-Kusch³, Lorenzo Ressel⁴, Jochen Friedemann³, Yury Shulhevich³, Patricia Murray², Bettina Wilm², Mark de Caestecker¹

¹Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, ²Department of Cellular and Molecular Physiology, University of Liverpool, ³MediBeacon GmbH, ⁴Department of Veterinary Pathology and Public Health, Institute of Veterinary Science, University of Liverpool

An In Vivo Method for Evaluating the Gut-Blood Barrier and Liver Metabolism of Microbiota Products

Kinga Jaworska¹, Tomasz Huc¹, Marta Gawrys¹, Maksymilian Onyszkiewicz¹, Emilia Samborowska², Marcin Ufnal¹

¹Department of Experimental Physiology and Pathophysiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, ²Mass Spectrometry Laboratory, Institute of Biochemistry and Biophysics, Polish Academy of Sciences

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