JoVE Journal

Medicine

JoVE Medicine connects biomedical research and clinical medicine featuring case studies, clinical procedures, surgeries, clinical trial methodologies and animal models of disease and treatment.

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Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

Shaun Pacheco¹, Shan-Yu Fung², Mingyao Liu^1,3

¹Latner Thoracic Surgery Research Laboratories, University Health Network, ²Department of Pediatrics, British Columbia Children's Hospital & University of British Columbia, ³Institute of Medical Science, University of Toronto

Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes

Jing Gao*¹, Xiaolu Shi*², Hong He¹, Juhong Zhang¹, Ding Lin³, Guosheng Fu¹, Dongwu Lai¹

¹Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, ²Experimental Research Center, China Academy of Chinese Medical Sciences, ³Department of Cardiology, The Third Hospital of Hangzhou City

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody (mAb) by Neutralizing TNF Using an In Vitro Bioanalytical Method

Lilia Tierrablanca-Sánchez¹, Víctor Pérez Medina Martínez¹, Nancy D. Ramírez Ibañez¹, Néstor O. Pérez Ramírez¹, Francisco Luis Flores Ortiz¹, Emilio Medina-Rivero²

¹Research and Development, Probiomed, ²Bioprocess Research and Development Unit, Instituto Politecnico Nacional

A Novel Method: Super-selective Adrenal Venous Sampling

Kohzoh Makita¹, Koshiro Nishimoto², Kanako Kiriyama-Kitamoto³, Shigehiro Karashima⁴, Tsugio Seki⁵, Masanori Yasuda⁶, Seishi Matsui⁷, Masao Omura³, Tetsuo Nishikawa³

¹Department of Radiology, Nerima Hikarigaoka Hospital, ²Department of Uro-Oncology, Saitama Medical University International Medical Center, ³Endocrinology & Diabetes Center, Yokohama Rosai Hospital, ⁴Division of Endocrinology and Metabolism, Kanazawa University Graduate School of Medicine, ⁵Department of Medical Education, School of Medicine, California University of Science and Medicine, ⁶Department of Pathology, Saitama Medical University International Medical Center, ⁷Department of Radiology, Yokohama Rosai Hospital

A Cell Culture Model of Resistance Arteries

Lauren A. Biwer^1,2, Christophe Lechauve³, Sheri Vanhoose⁴, Mitchell J. Weiss³, Brant E. Isakson^1,2

¹Department of Molecular Physiology and Biophysics, University of Virginia School of Medicine, ²Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, ³Department of Hematology, St. Jude Children's Research Hospital, ⁴Research Histology Core, University of Virginia School of Medicine

Application of an Amplitude-integrated EEG Monitor (Cerebral Function Monitor) to Neonates

Nora Bruns¹, Susanne Blumenthal¹, Irmgard Meyer¹, Susanne Klose-Verschuur¹, Ursula Felderhoff-Müser¹, Hanna Müller^1,2

¹Department of Pediatrics I, Neonatology, Pediatric Intensive Care, Pediatric Neurology, University Hospital Essen, University Duisburg-Essen, ²Division of Neonatology, Department of Pediatrics, University of Heidelberg

Assessment of the Anticoagulant and Anti-inflammatory Properties of Endothelial Cells Using 3D Cell Culture and Non-anticoagulated Whole Blood

Riccardo Sfriso^1,2, Anjan Bongoni³, Yara Banz⁴, Nikolai Klymiuk⁵, Eckhard Wolf⁵, Robert Rieben¹

¹Department of Clinical Research, University of Bern, ²Graduate School for Cellular and Biomedical Sciences, University of Bern, ³Immunology Research Centre, St. Vincent's Hospital Melbourne, ⁴Institute of Pathology, University of Bern, ⁵Institute of Molecular Animal Breeding and Biotechnology, Ludwig-Maximilian University

Induction and Micro-CT Imaging of Cerebral Cavernous Malformations in Mouse Model

Jaesung P. Choi^1,2, Xi Yang³, Matthew Foley⁴, Xian Wang¹, Xiangjian Zheng^1,2,3

¹Lab of Cardiovascular Signaling, Centenary Institute, ²Faculty of Medicine, Sydney Medical School, University of Sydney, ³Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, ⁴Australian Centre for Microscopy & Microanalysis, University of Sydney

Ultrasound-guided Intracardiac Injection of Human Mesenchymal Stem Cells to Increase Homing to the Intestine for Use in Murine Models of Experimental Inflammatory Bowel Diseases

Maneesh Dave¹, Paola Menghini¹, Keiki Sugi^2,3, Rodrigo A. Somoza⁵, Zhenghong Lee⁴, Mukesh Jain^2,3, Arnold Caplan⁵, Fabio Cominelli¹

¹Division of Gastroenterology and Liver Disease, University Hospitals, Digestive Health Research Institute, Case Western Reserve University, ²Case Cardiovascular Research Institute, School of Medicine, Case Western Reserve University, ³Department of Medicine, Harrington Discovery Institute, Harrington Heart and Vascular Institute, University Hospitals Case Medical Center, ⁴Department of Radiology, University Hospitals Case Medical Center, ⁵Department of Biology - Skeletal Research Center, Case Western Reserve University

Semi-automated Analysis of Mouse Skeletal Muscle Morphology and Fiber-type Composition

Sidharth Tyagi¹, Donald Beqollari¹, Chang Seok Lee², Lori A. Walker¹, Roger A. Bannister¹

¹Department of Medicine-Cardiology Division, University of Colorado School of Medicine, ²Department of Molecular Physiology and Biophysics, Baylor College of Medicine

A Novel Approach to Overcome Movement Artifact When Using a Laser Speckle Contrast Imaging System for Alternating Speeds of Blood Microcirculation

Shayan Bahadori¹, Tikki Immins¹, Thomas W. Wainwright¹

¹Orthopaedic Research Institute, Bournemouth University

Intravital Microscopy of Monocyte Homing and Tumor-Related Angiogenesis in a Murine Model of Peripheral Arterial Disease

Martin Wagner¹, Claudia Baer¹, Werner Zuschratter², Monika Riek-Burchardt³, Christian Deffge¹, Soenke Weinert¹, Jerry C Lee⁴, Ruediger C Braun-Dullaeus¹, Joerg Herold¹

¹Department of Cardiology and Angiology, University of Magdeburg, ²Leibniz Institute for Neurobiology, ³Institute of Molecular and Clinical Immunology, University of Magdeburg, ⁴Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Zhongwei Sun^1,2, Feng Li³, Xin Zhou³, Wen Wang^1,2

¹Cellular Biomedicine Group, Shanghai, ²Cellular Biomedicine Group, Cupertino, ³Department of Respiratory Medicine, Shanghai General Hospital, Shanghai Jiaotong University

Minimally Invasive Muscle Embedding (MIME) - A Novel Experimental Technique to Facilitate Donor-Cell-Mediated Myogenesis

Joseph A Roche¹, Morium Begam¹, Sujay S Galen¹

¹Department of Health Care Sciences, Physical Therapy Program, College of Pharmacy and Health Sciences, Wayne State University

Ileectomy-induced Bile Overaccumulation in Mouse Intestine

Rongli Zhang*^1,2,3, Jonathan W. Ray^1,2, Mukesh K. Jain^1,2, Shuxin Han*^1,2

¹Department of Medicine, Case Cardiovascular Research Institute, Case Western Reserve University, ²Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, ³Institute for Transformative Molecular Medicine, Case Western Reserve University School of Medicine, University Hospitals Cleveland Medical Center

Dissection of the Mouse Pancreas for Histological Analysis and Metabolic Profiling

Michelle J. Veite-Schmahl¹, Daniel P. Regan¹, Adam C. Rivers¹, Joseph F. Nowatzke^1,2, Michael A. Kennedy¹

¹Department of Chemistry & Biochemistry, Miami University, ²College of Medicine, Central Michigan University

Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation

Alison Michels¹, Laura L. Swystun¹, Jeffrey Mewburn², Silvia Albánez¹, David Lillicrap¹

¹Department of Pathology and Molecular Medicine, Queen's University, ²Department of Medicine, Queen's University

Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) Procedure

Erik Schadde^1,2,3, Martin Hertl², Stefan Breitenstein³, Beatrice Beck-Schimmer^1,4, Martin Schläpfer^1,4

¹Institute of Physiology - Center for Integrative Human Physiology, University of Zurich, ²Department of Surgery, Rush University Medical Center, ³Department of Surgery, Cantonal Hospital Winterthur, ⁴Institute of Anesthesiology, University and University Hospital Zurich

Surgical Angiogenesis in Porcine Tibial Allotransplantation: A New Large Animal Bone Vascularized Composite Allotransplantation Model

Dimitra Kotsougiani¹, Caroline A. Hundepool¹, Joost I. Willems¹, Patricia Friedrich¹, Alexander Y. Shin¹, Allen T. Bishop¹

¹Microvascular Research Laboratory, Department of Orthopedic Surgery, Mayo Clinic

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment

Mei Wang¹, Zhengluan Liao², Dewang Mao³, Qi Zhang¹, Yumei Li³, Enyan Yu², Zhongxiang Ding³

¹Zhejiang Chinese Medical University, ²Department of Psychiatry, Zhejiang Provincial People's Hospital, ³Department of Radiology, Zhejiang Provincial People's Hospital

A Novel Clinical Grade Isolation Method for Human Kidney Perivascular Stromal Cells

Daniëlle G. Leuning¹, Ellen Lievers¹, Marlies E.J. Reinders¹, Cees van Kooten¹, Marten A. Engelse¹, Ton J. Rabelink¹

¹Department of Internal Medicine, Leiden University Medical Centre

Creation and Transplantation of an Adipose-derived Stem Cell (ASC) Sheet in a Diabetic Wound-healing Model

Yuka Kato¹, Takanori Iwata², Kaoru Washio², Toshiyuki Yoshida², Hozue Kuroda², Shunichi Morikawa³, Mariko Hamada¹, Kazuki Ikura¹, Nobuyuki Kaibuchi², Masayuki Yamato², Teruo Okano², Yasuko Uchigata¹

¹Diabetic Center, Tokyo Women's Medical University School of Medicine, ²The Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, ³The Department of Anatomy and Developmental Biology, Tokyo Women's Medical University School of Medicine

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

Ane M. Holme^1,2, Maia B. Holm^1,2, Marie C. P. Roland^1,3, Hildegunn Horne^1,2, Trond M. Michelsen^1,3, Guttorm Haugen^2,4, Tore Henriksen^1,2

¹Department of Obstetrics, Oslo University Hospital, ²Institute of Clinical Medicine, University of Oslo, ³Norwegian Advisory Unit on Women's Health, Oslo University Hospital, ⁴Department of Fetal Medicine, Oslo University Hospital

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

Jessica X. Yuan, Jennifer M. Munson

¹Biomedical Engineering, University of Virginia

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