Arthur L. Horwich

Publications

• Chaperonin-mediated Protein Folding
  The Journal of Biological Chemistry. Aug, 2013  |   Pubmed ID: 23803606
• Molecular Chaperone Hsp110 Rescues a Vesicle Transport Defect Produced by an ALS-associated Mutant SOD1 Protein in Squid Axoplasm
  Proceedings of the National Academy of Sciences of the United States of America. Apr, 2013  |   Pubmed ID: 23509252
• Recessive Loss of Function of the Neuronal Ubiquitin Hydrolase UCHL1 Leads to Early-onset Progressive Neurodegeneration
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2013  |   Pubmed ID: 23359680
• RNA-Seq Profiling of Spinal Cord Motor Neurons from a Presymptomatic SOD1 ALS Mouse
  PloS One. 2013  |   Pubmed ID: 23301088
• Structure and Allostery of the Chaperonin GroEL
  Journal of Molecular Biology. May, 2013  |   Pubmed ID: 23183375
• ATP-triggered Conformational Changes Delineate Substrate-binding and -folding Mechanics of the GroEL Chaperonin
  Cell. Mar, 2012  |   Pubmed ID: 22445172
• QnAs with Arthur L. Horwich. Interview by Prashant Nair
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2012  |   Pubmed ID: 22308493
• Protein Folding in the Cell: an Inside Story
  Nature Medicine. Oct, 2011  |   Pubmed ID: 21989012
• Translational Diffusion of Macromolecular Assemblies Measured Using Transverse-relaxation-optimized Pulsed Field Gradient NMR
  Journal of the American Chemical Society. Oct, 2011  |   Pubmed ID: 21919531
• Localization of GroEL Determined by in Vivo Incorporation of a Fluorescent Amino Acid
  Bioorganic & Medicinal Chemistry Letters. Oct, 2011  |   Pubmed ID: 21890355
• Hydrogen-deuterium Exchange in Vivo to Measure Turnover of an ALS-associated Mutant SOD1 Protein in Spinal Cord of Mice
  Protein Science : a Publication of the Protein Society. Oct, 2011  |   Pubmed ID: 21780215
• Nuclear Magnetic Resonance Spectroscopy with the Stringent Substrate Rhodanese Bound to the Single-ring Variant SR1 of the E. Coli Chaperonin GroEL
  Protein Science : a Publication of the Protein Society. Aug, 2011  |   Pubmed ID: 21633984
• Double Mutant MBP Refolds at Same Rate in Free Solution As Inside the GroEL/GroES Chaperonin Chamber when Aggregation in Free Solution is Prevented
  FEBS Letters. Jun, 2011  |   Pubmed ID: 21609718
• ATP-triggered ADP Release from the Asymmetric Chaperonin GroEL/GroES/ADP7 is Not the Rate-limiting Step of the GroEL/GroES Reaction Cycle
  FEBS Letters. Mar, 2010  |   Pubmed ID: 20083109
• GroEL/GroES Cycling: ATP Binds to an Open Ring Before Substrate Protein Favoring Protein Binding and Production of the Native State
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 2009  |   Pubmed ID: 19915138
• Chaperonin-mediated Protein Folding: Using a Central Cavity to Kinetically Assist Polypeptide Chain Folding
  Quarterly Reviews of Biophysics. May, 2009  |   Pubmed ID: 19638247
• The GroEL/GroES Cis Cavity As a Passive Anti-aggregation Device
  FEBS Letters. Aug, 2009  |   Pubmed ID: 19577567
• Progressive Aggregation Despite Chaperone Associations of a Mutant SOD1-YFP in Transgenic Mice That Develop ALS
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2009  |   Pubmed ID: 19171884
• An ALS-linked Mutant SOD1 Produces a Locomotor Defect Associated with Aggregation and Synaptic Dysfunction when Expressed in Neurons of Caenorhabditis Elegans
  PLoS Genetics. Jan, 2009  |   Pubmed ID: 19165329
• A Small Molecule Inhibitor Selective for a Variant ATP-binding Site of the Chaperonin GroEL
  Bioorganic & Medicinal Chemistry Letters. Feb, 2009  |   Pubmed ID: 19110421
• Requirement for Binding Multiple ATPs to Convert a GroEL Ring to the Folding-active State
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 2008  |   Pubmed ID: 19050077
• Chaperonin Chamber Accelerates Protein Folding Through Passive Action of Preventing Aggregation
  Proceedings of the National Academy of Sciences of the United States of America. Nov, 2008  |   Pubmed ID: 18987317
• Multiple States of a Nucleotide-bound Group 2 Chaperonin
  Structure (London, England : 1993). Apr, 2008  |   Pubmed ID: 18400175
• Folding Trajectories of Human Dihydrofolate Reductase Inside the GroEL GroES Chaperonin Cavity and Free in Solution
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 2007  |   Pubmed ID: 18093916
• Topologies of a Substrate Protein Bound to the Chaperonin GroEL
  Molecular Cell. May, 2007  |   Pubmed ID: 17499047
• Two Families of Chaperonin: Physiology and Mechanism
  Annual Review of Cell and Developmental Biology. 2007  |   Pubmed ID: 17489689
• Perturbed ATPase Activity and Not "close Confinement" of Substrate in the Cis Cavity Affects Rates of Folding by Tail-multiplied GroEL
  Proceedings of the National Academy of Sciences of the United States of America. Mar, 2007  |   Pubmed ID: 17372195
• Disulfide Formation As a Probe of Folding in GroEL-GroES Reveals Correct Formation of Long-range Bonds and Editing of Incorrect Short-range Ones
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2007  |   Pubmed ID: 17283341
• Global Aggregation of Newly Translated Proteins in an Escherichia Coli Strain Deficient of the Chaperonin GroEL
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2006  |   Pubmed ID: 17043235
• Proton-proton Overhauser NMR Spectroscopy with Polypeptide Chains in Large Structures
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2006  |   Pubmed ID: 17032756
• GroEL-GroES-mediated Protein Folding
  Chemical Reviews. May, 2006  |   Pubmed ID: 16683761
• Allosteric Signaling of ATP Hydrolysis in GroEL-GroES Complexes
  Nature Structural & Molecular Biology. Feb, 2006  |   Pubmed ID: 16429154
• Probing the Sequence of Conformationally Induced Polarity Changes in the Molecular Chaperonin GroEL with Fluorescence Spectroscopy
  The Journal of Physical Chemistry. B. Dec, 2005  |   Pubmed ID: 16375456
• Roles of the N-domains of the ClpA Unfoldase in Binding Substrate Proteins and in Stable Complex Formation with the ClpP Protease
  The Journal of Biological Chemistry. Dec, 2005  |   Pubmed ID: 16207718
• Direct NMR Observation of a Substrate Protein Bound to the Chaperonin GroEL
  Proceedings of the National Academy of Sciences of the United States of America. Sep, 2005  |   Pubmed ID: 16116078
• Loops in the Central Channel of ClpA Chaperone Mediate Protein Binding, Unfolding, and Translocation
  Cell. Jul, 2005  |   Pubmed ID: 15989953
• No Evidence for a Forced-unfolding Mechanism During ATP/GroES Binding to Substrate-bound GroEL: No Observable Protection of Metastable Rubisco Intermediate or GroEL-bound Rubisco from Tritium Exchange
  FEBS Letters. Feb, 2005  |   Pubmed ID: 15710410
• Chaperoned Protein Disaggregation--the ClpB Ring Uses Its Central Channel
  Cell. Nov, 2004  |   Pubmed ID: 15550237
• Substrate Polypeptide Presents a Load on the Apical Domains of the Chaperonin GroEL
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2004  |   Pubmed ID: 15479763
• A Mutant Chaperonin with Rearranged Inter-ring Electrostatic Contacts and Temperature-sensitive Dissociation
  Nature Structural & Molecular Biology. Nov, 2004  |   Pubmed ID: 15475965
• Exploring the Structural Dynamics of the E.coli Chaperonin GroEL Using Translation-libration-screw Crystallographic Refinement of Intermediate States
  Journal of Molecular Biology. Sep, 2004  |   Pubmed ID: 15313620
• Uniform and Residue-specific 15N-labeling of Proteins on a Highly Deuterated Background
  Journal of Biomolecular NMR. Jul, 2004  |   Pubmed ID: 15213427
• Chaperonin-mediated Protein Folding: Fate of Substrate Polypeptide
  Quarterly Reviews of Biophysics. May, 2003  |   Pubmed ID: 14686103
• Role of the Gamma-phosphate of ATP in Triggering Protein Folding by GroEL-GroES: Function, Structure and Energetics
  The EMBO Journal. Oct, 2003  |   Pubmed ID: 14517228
• Folding with and Without Encapsulation by Cis- and Trans-only GroEL-GroES Complexes
  The EMBO Journal. Jul, 2003  |   Pubmed ID: 12839985
• Solution NMR Techniques for Large Molecular and Supramolecular Structures
  Journal of the American Chemical Society. Oct, 2002  |   Pubmed ID: 12371854
• NMR Analysis of a 900K GroEL GroES Complex
  Nature. Jul, 2002  |   Pubmed ID: 12110894
• ClpS, a Substrate Modulator of the ClpAP Machine
  Molecular Cell. Mar, 2002  |   Pubmed ID: 11931773