Christoph Wittmann Institute of Biochemical Engineering Technische Universität Braunschweig Biography Publications Institution JoVE Articles Christoph Wittmann has not added a biography. If you are Christoph Wittmann and would like to personalize this page please email our Author Liaison for assistance. Publications Industrial Biotechnology of Pseudomonas Putida and Related Species Applied Microbiology and Biotechnology. Mar, 2012 | Pubmed ID: 22350258 Debottlenecking Recombinant Protein Production in Bacillus Megaterium Under Large Scale Conditions - Targeted Precursor Feeding Designed from Metabolomics Biotechnology and Bioengineering. Jan, 2012 | Pubmed ID: 22252649 Systems and Synthetic Metabolic Engineering for Amino Acid Production - the Heartbeat of Industrial Strain Development Current Opinion in Biotechnology. Jan, 2012 | Pubmed ID: 22244788 Microbial Production of the Drugs Violacein and Deoxyviolacein: Analytical Development and Strain Comparison Biotechnology Letters. Apr, 2012 | Pubmed ID: 22187076 Integration of in Vivo and in Silico Metabolic Fluxes for Improvement of Recombinant Protein Production Metabolic Engineering. Jan, 2012 | Pubmed ID: 22115737 Improved Enzyme Production by Bio-pellets of Aspergillus Niger: Targeted Morphology Engineering Using Titanate Microparticles Biotechnology and Bioengineering. Feb, 2012 | Pubmed ID: 21887774 Bio-based Production of Chemicals, Materials and Fuels -Corynebacterium Glutamicum As Versatile Cell Factory Current Opinion in Biotechnology. Dec, 2011 | Pubmed ID: 22138494 Systems Biology of Recombinant Protein Production Using Bacillus Megaterium Methods in Enzymology. 2011 | Pubmed ID: 21943898 Metabolic Engineering of Cellular Transport for Overproduction of the Platform Chemical 1,5-diaminopentane in Corynebacterium Glutamicum Metabolic Engineering. Sep, 2011 | Pubmed ID: 21821142 Bio-based Production of the Platform Chemical 1,5-diaminopentane Applied Microbiology and Biotechnology. Sep, 2011 | Pubmed ID: 21761208 Filamentous Fungi in Good Shape: Microparticles for Tailor-made Fungal Morphology and Enhanced Enzyme Production Bioengineered Bugs. Mar-Apr, 2011 | Pubmed ID: 21636997 Metabolic Engineering of Corynebacterium Glutamicum for Production of 1,5-diaminopentane from Hemicellulose Biotechnology Journal. Mar, 2011 | Pubmed ID: 21298810 From Zero to Hero--design-based Systems Metabolic Engineering of Corynebacterium Glutamicum for L-lysine Production Metabolic Engineering. Mar, 2011 | Pubmed ID: 21241816 Metabolic Fluxes and Beyond-systems Biology Understanding and Engineering of Microbial Metabolism Applied Microbiology and Biotechnology. Nov, 2010 | Pubmed ID: 20821203 Towards Methionine Overproduction in Corynebacterium Glutamicum--methanethiol and Dimethyldisulfide As Reduced Sulfur Sources Journal of Microbiology and Biotechnology. Aug, 2010 | Pubmed ID: 20798582 Identification and Elimination of the Competing N-acetyldiaminopentane Pathway for Improved Production of Diaminopentane by Corynebacterium Glutamicum Applied and Environmental Microbiology. Aug, 2010 | Pubmed ID: 20562290 Optimized Bioprocess for Production of Fructofuranosidase by Recombinant Aspergillus Niger Applied Microbiology and Biotechnology. Aug, 2010 | Pubmed ID: 20502893 Systems-wide Metabolic Pathway Engineering in Corynebacterium Glutamicum for Bio-based Production of Diaminopentane Metabolic Engineering. Jul, 2010 | Pubmed ID: 20381632 Analysis and Engineering of Metabolic Pathway Fluxes in Corynebacterium Glutamicum Advances in Biochemical Engineering/biotechnology. 2010 | Pubmed ID: 20140657 Morphology Engineering of Aspergillus Niger for Improved Enzyme Production Biotechnology and Bioengineering. Apr, 2010 | Pubmed ID: 19953678 Flux Design: In Silico Design of Cell Factories Based on Correlation of Pathway Fluxes to Desired Properties BMC Systems Biology. 2009 | Pubmed ID: 20035624 Metabolic Engineering of the Tricarboxylic Acid Cycle for Improved Lysine Production by Corynebacterium Glutamicum Applied and Environmental Microbiology. Dec, 2009 | Pubmed ID: 19820141 Metabolic Fluxes in the Central Carbon Metabolism of Dinoroseobacter Shibae and Phaeobacter Gallaeciensis, Two Members of the Marine Roseobacter Clade BMC Microbiology. 2009 | Pubmed ID: 19788729 OpenFLUX: Efficient Modelling Software for 13C-based Metabolic Flux Analysis Microbial Cell Factories. 2009 | Pubmed ID: 19409084 Investigation of the Central Carbon Metabolism of Sorangium Cellulosum: Metabolic Network Reconstruction and Quantification of Pathway Fluxes Journal of Microbiology and Biotechnology. Jan, 2009 | Pubmed ID: 19190405 Metabolite Profiling Studies in Saccharomyces Cerevisiae: an Assisting Tool to Prioritize Host Targets for Antiviral Drug Screening Microbial Cell Factories. 2009 | Pubmed ID: 19183481 Physiological Response of Corynebacterium Glutamicum to Oxidative Stress Induced by Deletion of the Transcriptional Repressor McbR Microbiology (Reading, England). Dec, 2008 | Pubmed ID: 19047758 Appropriate Sampling for Intracellular Amino Acid Analysis in Five Phylogenetically Different Yeasts Biotechnology Letters. Nov, 2008 | Pubmed ID: 18604477 Analysis of 13C Labeling Enrichment in Microbial Culture Applying Metabolic Tracer Experiments Using Gas Chromatography-combustion-isotope Ratio Mass Spectrometry Analytical Biochemistry. Sep, 2008 | Pubmed ID: 18565321 The Yeast Kluyveromyces Marxianus and Its Biotechnological Potential Applied Microbiology and Biotechnology. Jun, 2008 | Pubmed ID: 18427804 Metabolic Responses to Pyruvate Kinase Deletion in Lysine Producing Corynebacterium Glutamicum Microbial Cell Factories. 2008 | Pubmed ID: 18339202 Complete Genome Sequence of the Myxobacterium Sorangium Cellulosum Nature Biotechnology. Nov, 2007 | Pubmed ID: 17965706 Metabolic Flux Screening of Saccharomyces Cerevisiae Single Knockout Strains on Glucose and Galactose Supports Elucidation of Gene Function Journal of Biotechnology. Dec, 2007 | Pubmed ID: 17919760 Effect of Different Carbon Sources on Central Metabolic Fluxes and the Recombinant Production of a Hydrolase from Thermobifida Fusca in Bacillus Megaterium Journal of Biotechnology. Dec, 2007 | Pubmed ID: 17826861 Response of Fluxome and Metabolome to Temperature-induced Recombinant Protein Synthesis in Escherichia Coli Journal of Biotechnology. Dec, 2007 | Pubmed ID: 17689798 Response of the Central Metabolism of Escherichia Coli to Modified Expression of the Gene Encoding the Glucose-6-phosphate Dehydrogenase FEBS Letters. Aug, 2007 | Pubmed ID: 17631881 Metabolic Flux Engineering of L-lysine Production in Corynebacterium Glutamicum--over Expression and Modification of G6P Dehydrogenase Journal of Biotechnology. Oct, 2007 | Pubmed ID: 17624457 Sampling for Metabolome Analysis of Microorganisms Analytical Chemistry. May, 2007 | Pubmed ID: 17411014 Fluxome Analysis Using GC-MS Microbial Cell Factories. 2007 | Pubmed ID: 17286851 Physiology of the Yeast Kluyveromyces Marxianus During Batch and Chemostat Cultures with Glucose As the Sole Carbon Source FEMS Yeast Research. May, 2007 | Pubmed ID: 17233766 Matrix-assisted Laser Desorption/ionization Time-of-flight Mass Spectrometry for Metabolic Flux Analyses Using Isotope-labeled Ethanol Rapid Communications in Mass Spectrometry : RCM. 2007 | Pubmed ID: 17206598 Transcriptional and Metabolic Responses of Bacillus Subtilis to the Availability of Organic Acids: Transcription Regulation is Important but Not Sufficient to Account for Metabolic Adaptation Applied and Environmental Microbiology. Jan, 2007 | Pubmed ID: 17122393 Comparative Study on Central Metabolic Fluxes of Bacillus Megaterium Strains in Continuous Culture Using 13C Labelled Substrates Bioprocess and Biosystems Engineering. Jan, 2007 | Pubmed ID: 17086410 Respirometric 13C Flux Analysis, Part I: Design, Construction and Validation of a Novel Multiple Reactor System Using On-line Membrane Inlet Mass Spectrometry Metabolic Engineering. Sep, 2006 | Pubmed ID: 16844397 Respirometric 13C Flux Analysis--Part II: in Vivo Flux Estimation of Lysine-producing Corynebacterium Glutamicum Metabolic Engineering. Sep, 2006 | Pubmed ID: 16750927 Metabolic Pathway Analysis for Rational Design of L-methionine Production by Escherichia Coli and Corynebacterium Glutamicum Metabolic Engineering. Jul, 2006 | Pubmed ID: 16621639 Accumulation of Homolanthionine and Activation of a Novel Pathway for Isoleucine Biosynthesis in Corynebacterium Glutamicum McbR Deletion Strains Journal of Bacteriology. Jan, 2006 | Pubmed ID: 16385051 Quantification of S-adenosyl Methionine in Microbial Cell Extracts Biotechnology Letters. Jan, 2006 | Pubmed ID: 16369687 Amplified Expression of Fructose 1,6-bisphosphatase in Corynebacterium Glutamicum Increases in Vivo Flux Through the Pentose Phosphate Pathway and Lysine Production on Different Carbon Sources Applied and Environmental Microbiology. Dec, 2005 | Pubmed ID: 16332851 Application of Cation-exchange Membranes for Characterisation and Imaging Ammonia-oxidising Bacteria in Soils FEMS Microbiology Ecology. Aug, 2005 | Pubmed ID: 16329964 Characterization of the Metabolic Shift Between Oxidative and Fermentative Growth in Saccharomyces Cerevisiae by Comparative 13C Flux Analysis Microbial Cell Factories. Nov, 2005 | Pubmed ID: 16269086 Theoretical Aspects of 13C Metabolic Flux Analysis with Sole Quantification of Carbon Dioxide Labeling Computational Biology and Chemistry. Apr, 2005 | Pubmed ID: 15833440 In Vivo Quantification of Intracellular Amino Acids and Intermediates of the Methionine Pathway in Corynebacterium Glutamicum Analytical Biochemistry. May, 2005 | Pubmed ID: 15802143 Dynamics of Intracellular Metabolites of Glycolysis and TCA Cycle During Cell-cycle-related Oscillation in Saccharomyces Cerevisiae Biotechnology and Bioengineering. Mar, 2005 | Pubmed ID: 15690349 Metabolic Fluxes in Corynebacterium Glutamicum During Lysine Production with Sucrose As Carbon Source Applied and Environmental Microbiology. Dec, 2004 | Pubmed ID: 15574927 Metabolic Network Simulation Using Logical Loop Algorithm and Jacobian Matrix Metabolic Engineering. Oct, 2004 | Pubmed ID: 15491855 Metabolic Network Analysis of Lysine Producing Corynebacterium Glutamicum at a Miniaturized Scale Biotechnology and Bioengineering. Jul, 2004 | Pubmed ID: 15211482 Impact of the Cold Shock Phenomenon on Quantification of Intracellular Metabolites in Bacteria Analytical Biochemistry. Apr, 2004 | Pubmed ID: 15033521 Minibioreactors Biotechnology Letters. Jan, 2004 | Pubmed ID: 15005143 In-depth Profiling of Lysine-producing Corynebacterium Glutamicum by Combined Analysis of the Transcriptome, Metabolome, and Fluxome Journal of Bacteriology. Mar, 2004 | Pubmed ID: 14996808 Comparative Metabolic Flux Analysis of Lysine-producing Corynebacterium Glutamicum Cultured on Glucose or Fructose Applied and Environmental Microbiology. Jan, 2004 | Pubmed ID: 14711646 Software Tool for Automated Processing of 13C Labeling Data from Mass Spectrometric Spectra BioTechniques. Dec, 2003 | Pubmed ID: 14682055 Dynamic Calibration and Dissolved Gas Analysis Using Membrane Inlet Mass Spectrometry for the Quantification of Cell Respiration Rapid Communications in Mass Spectrometry : RCM. 2003 | Pubmed ID: 14673819 Characterization and Application of an Optical Sensor for Quantification of Dissolved O2 in Shake-flasks Biotechnology Letters. Mar, 2003 | Pubmed ID: 12882556 Free Intracellular Amino Acid Pools During Autonomous Oscillations in Saccharomyces Cerevisiae Biotechnology and Bioengineering. Apr, 2003 | Pubmed ID: 12584756 Integrated Optical Sensing of Dissolved Oxygen in Microtiter Plates: a Novel Tool for Microbial Cultivation Biotechnology and Bioengineering. Mar, 2003 | Pubmed ID: 12557316 Genealogy Profiling Through Strain Improvement by Using Metabolic Network Analysis: Metabolic Flux Genealogy of Several Generations of Lysine-producing Corynebacteria Applied and Environmental Microbiology. Dec, 2002 | Pubmed ID: 12450803 Metabolic Physiology of Aroma-producing Kluyveromyces Marxianus Yeast (Chichester, England). Nov, 2002 | Pubmed ID: 12402244 Correcting Mass Isotopomer Distributions for Naturally Occurring Isotopes Biotechnology and Bioengineering. Nov, 2002 | Pubmed ID: 12325156 Derivatization of Small Biomolecules for Optimized Matrix-assisted Laser Desorption/ionization Mass Spectrometry Journal of Mass Spectrometry : JMS. Sep, 2002 | Pubmed ID: 12271439 In Vivo Analysis of Intracellular Amino Acid Labelings by GC/MS Analytical Biochemistry. Aug, 2002 | Pubmed ID: 12202258 Customization of Aspergillus niger Morphology Through Addition of Talc Micro Particles Thomas Wucherpfennig1, Antonia Lakowitz1, Habib Driouch1, Rainer Krull1, Christoph Wittmann1 1Institute of Biochemical Engineering, Technische Universität Braunschweig JoVE 4023 면역학 및 감염병학
Customization of Aspergillus niger Morphology Through Addition of Talc Micro Particles Thomas Wucherpfennig1, Antonia Lakowitz1, Habib Driouch1, Rainer Krull1, Christoph Wittmann1 1Institute of Biochemical Engineering, Technische Universität Braunschweig JoVE 4023 면역학 및 감염병학