Pramod Upadhyaya Masonic Cancer Center University of Minnesota Biography Publications Institution JoVE Articles Pramod Upadhyaya has not added a biography. If you are Pramod Upadhyaya and would like to personalize this page please email our Author Liaison for assistance. Publications Pilot in Vivo Structure-Activity Relationship of Dihydromethysticin in Blocking 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced O(6)-Methylguanine and Lung Tumor in A/J Mice Journal of Medicinal Chemistry. Sep, 2017 | Pubmed ID: 28806079 Investigation of the Presence in Human Urine of Mercapturic Acids Derived from Phenanthrene, a Representative Polycyclic Aromatic Hydrocarbon Chemico-biological Interactions. Aug, 2017 | Pubmed ID: 28693886 Identification of 4-(3-Pyridyl)-4-oxobutyl-2'-deoxycytidine Adducts Formed in the Reaction of DNA with 4-(Acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone: A Chemically Activated Form of Tobacco-Specific Carcinogens ACS Omega. Mar, 2017 | Pubmed ID: 28393135 Evaluation of Nitrosamide Formation in the Cytochrome P450-Mediated Metabolism of Tobacco-Specific Nitrosamines Chemical Research in Toxicology. Dec, 2016 | Pubmed ID: 27989137 Dihydromethysticin (DHM) Blocks Tobacco Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-Induced O(6)-Methylguanine in a Manner Independent of the Aryl Hydrocarbon Receptor (AhR) Pathway in C57BL/6 Female Mice Chemical Research in Toxicology. Nov, 2016 | Pubmed ID: 27728767 Harnessing the Power of Cruciferous Vegetables: Developing a Biomarker for Brassica Vegetable Consumption Using Urinary 3,3'-Diindolylmethane Cancer Prevention Research (Philadelphia, Pa.). Oct, 2016 | Pubmed ID: 27538743 Honokiol Suppresses Lung Tumorigenesis by Targeting EGFR and Its Downstream Effectors Oncotarget. Sep, 2016 | Pubmed ID: 27458163 Multiclass Carcinogenic DNA Adduct Quantification in Formalin-Fixed Paraffin-Embedded Tissues by Ultraperformance Liquid Chromatography-Tandem Mass Spectrometry Analytical Chemistry. May, 2016 | Pubmed ID: 27043225 Clinical Trial of 2-Phenethyl Isothiocyanate As an Inhibitor of Metabolic Activation of a Tobacco-Specific Lung Carcinogen in Cigarette Smokers Cancer Prevention Research (Philadelphia, Pa.). 05, 2016 | Pubmed ID: 26951845 Research on Cruciferous Vegetables, Indole-3-carbinol, and Cancer Prevention: A Tribute to Lee W. Wattenberg Molecular Nutrition & Food Research. Jun, 2016 | Pubmed ID: 26840393 DNA Adduct Formation from Metabolic 5'-Hydroxylation of the Tobacco-Specific Carcinogen N'-Nitrosonornicotine in Human Enzyme Systems and in Rats Chemical Research in Toxicology. Mar, 2016 | Pubmed ID: 26808005 Transcriptome Profiling in Oral Cavity and Esophagus Tissues from (S)-N'-nitrosonornicotine-treated Rats Reveals Candidate Genes Involved in Human Oral Cavity and Esophageal Carcinogenesis Molecular Carcinogenesis. Dec, 2016 | Pubmed ID: 26785143 Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification Drug Metabolism and Disposition: the Biological Fate of Chemicals. Mar, 2016 | Pubmed ID: 26744252 Analysis of O(6)-[4-(3-Pyridyl)-4-oxobut-1-yl]-2'-deoxyguanosine and Other DNA Adducts in Rats Treated with Enantiomeric or Racemic N'-Nitrosonornicotine Chemical Research in Toxicology. Jan, 2016 | Pubmed ID: 26633576 Comprehensive High-Resolution Mass Spectrometric Analysis of DNA Phosphate Adducts Formed by the Tobacco-Specific Lung Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone Chemical Research in Toxicology. Nov, 2015 | Pubmed ID: 26398225 Combinations of Indole-3-carbinol and Silibinin Suppress Inflammation-driven Mouse Lung Tumorigenesis by Modulating Critical Cell Cycle Regulators Carcinogenesis. Jun, 2015 | Pubmed ID: 25896445 RNA-sequencing Studies Identify Genes Differentially Regulated During Inflammation-driven Lung Tumorigenesis and Targeted by Chemopreventive Agents Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]. May, 2015 | Pubmed ID: 25795230 Quantitative Analysis of 3'-hydroxynorcotinine in Human Urine Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco. May, 2015 | Pubmed ID: 25324430 Intranasal Delivery of Liposomal Indole-3-carbinol Improves Its Pulmonary Bioavailability International Journal of Pharmaceutics. Dec, 2014 | Pubmed ID: 25311179 Carcinogenicity and DNA Adduct Formation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and Enantiomers of Its Metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in F-344 Rats Carcinogenesis. Dec, 2014 | Pubmed ID: 25269804 Liquid Chromatography-electrospray Ionization-tandem Mass Spectrometry Quantitation of Urinary [pyridine-D4]4-hydroxy-4-(3-pyridyl)butanoic Acid, a Biomarker of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone Metabolic Activation in Smokers Chemical Research in Toxicology. Sep, 2014 | Pubmed ID: 25098652 Dihydromethysticin from Kava Blocks Tobacco Carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced Lung Tumorigenesis and Differentially Reduces DNA Damage in A/J Mice Carcinogenesis. Oct, 2014 | Pubmed ID: 25053626 Application of a High-resolution Mass-spectrometry-based DNA Adductomics Approach for Identification of DNA Adducts in Complex Mixtures Analytical Chemistry. Feb, 2014 | Pubmed ID: 24410521 Kava Blocks 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced Lung Tumorigenesis in Association with Reducing O6-methylguanine DNA Adduct in A/J Mice Cancer Prevention Research (Philadelphia, Pa.). Jan, 2014 | Pubmed ID: 24403291 Urinary 3,3'-diindolylmethane: a Biomarker of Glucobrassicin Exposure and Indole-3-carbinol Uptake in Humans Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology. Feb, 2014 | Pubmed ID: 24357105 Quantitation of Pyridyloxobutyl-DNA Adducts in Tissues of Rats Treated Chronically with (R)- or (S)-N'-nitrosonornicotine (NNN) in a Carcinogenicity Study Chemical Research in Toxicology. Oct, 2013 | Pubmed ID: 24001146 Contamination of Deconjugation Enzymes Derived from Helix Pomatia with the Plant Bioactive Compounds 3,3'-diindolylmethane, 5-methoxypsoralen, and 8-methoxypsoralen Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association. Dec, 2013 | Pubmed ID: 23994708 (S)-N'-Nitrosonornicotine, a Constituent of Smokeless Tobacco, is a Powerful Oral Cavity Carcinogen in Rats Carcinogenesis. Sep, 2013 | Pubmed ID: 23671129 DNA Adducts in Aldehyde Dehydrogenase-positive Lung Stem Cells of A/J Mice Treated with the Tobacco Specific Lung Carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) Chemical Research in Toxicology. Apr, 2013 | Pubmed ID: 23477619 Chemoprevention of Lung Tumorigenesis by Intranasally Administered Diindolylmethane in A/J Mice Carcinogenesis. Apr, 2013 | Pubmed ID: 23239747 Levels of (S)-N'-nitrosonornicotine in U.S. Tobacco Products Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco. Jul, 2013 | Pubmed ID: 23212437 Formation and Repair of Pyridyloxobutyl DNA Adducts and Their Relationship to Tumor Yield in A/J Mice Chemical Research in Toxicology. Oct, 2012 | Pubmed ID: 22928598 The Sphingolipid Degradation Product Trans-2-hexadecenal Forms Adducts with DNA Biochemical and Biophysical Research Communications. Jul, 2012 | Pubmed ID: 22727907 Phenanthrene Metabolism in Smokers: Use of a Two-step Diagnostic Plot Approach to Identify Subjects with Extensive Metabolic Activation The Journal of Pharmacology and Experimental Therapeutics. Sep, 2012 | Pubmed ID: 22674470 Indole-3-carbinol Inhibited Tobacco Smoke Carcinogen-induced Lung Adenocarcinoma in A/J Mice when Administered During the Post-initiation or Progression Phase of Lung Tumorigenesis Cancer Letters. Dec, 2011 | Pubmed ID: 21767909 Lung Tumorigenesis Suppressing Effects of a Commercial Kava Extract and Its Selected Compounds in A/J Mice The American Journal of Chinese Medicine. 2011 | Pubmed ID: 21721153 Metabolism of [D10]phenanthrene to Tetraols in Smokers for Potential Lung Cancer Susceptibility Assessment: Comparison of Oral and Inhalation Routes of Administration The Journal of Pharmacology and Experimental Therapeutics. Jul, 2011 | Pubmed ID: 21515812 Evolution of Research on the DNA Adduct Chemistry of N-nitrosopyrrolidine and Related Aldehydes Chemical Research in Toxicology. Jun, 2011 | Pubmed ID: 21480629 Enhanced Inhibition of Lung Adenocarcinoma by Combinatorial Treatment with Indole-3-carbinol and Silibinin in A/J Mice Carcinogenesis. Apr, 2011 | Pubmed ID: 21273642 Immediate Consequences of Cigarette Smoking: Rapid Formation of Polycyclic Aromatic Hydrocarbon Diol Epoxides Chemical Research in Toxicology. Feb, 2011 | Pubmed ID: 21184614 Inhibition of Lung Carcinogenesis and Critical Cancer-related Signaling Pathways by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-l-cysteine, Indole-3-carbinol and Myo-inositol, Alone and in Combination Carcinogenesis. Sep, 2010 | Pubmed ID: 20603442 Preferential Glutathione Conjugation of a Reverse Diol Epoxide Compared with a Bay Region Diol Epoxide of Benzo[a]pyrene in Human Hepatocytes Drug Metabolism and Disposition: the Biological Fate of Chemicals. Sep, 2010 | Pubmed ID: 20547966 Formation and Distribution of NNK Metabolites in an Isolated Perfused Rat Lung Drug Metabolism and Disposition: the Biological Fate of Chemicals. May, 2010 | Pubmed ID: 20159989 Inhibition of Vinyl Carbamate-induced Pulmonary Adenocarcinoma by Indole-3-carbinol and Myo-inositol in A/J Mice Carcinogenesis. Feb, 2010 | Pubmed ID: 19625346 Analysis of Pyridyloxobutyl and Pyridylhydroxybutyl DNA Adducts in Extrahepatic Tissues of F344 Rats Treated Chronically with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and Enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol Chemical Research in Toxicology. May, 2009 | Pubmed ID: 19358518 Comparative Levels of O6-methylguanine, Pyridyloxobutyl-, and Pyridylhydroxybutyl-DNA Adducts in Lung and Liver of Rats Treated Chronically with the Tobacco-specific Carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone Drug Metabolism and Disposition: the Biological Fate of Chemicals. Jun, 2009 | Pubmed ID: 19324941 Dose-dependent Inhibition of Tobacco Smoke Carcinogen-induced Lung Tumorigenesis in A/J Mice by Indole-3-carbinol Cancer Prevention Research (Philadelphia, Pa.). Dec, 2008 | Pubmed ID: 19139007 Chemopreventive Effect of Kava on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone Plus Benzo[a]pyrene-induced Lung Tumorigenesis in A/J Mice Cancer Prevention Research (Philadelphia, Pa.). Nov, 2008 | Pubmed ID: 19138990 Combinations of N-Acetyl-S-(N-2-Phenethylthiocarbamoyl)-L-Cysteine and Myo-inositol Inhibit Tobacco Carcinogen-induced Lung Adenocarcinoma in Mice Cancer Prevention Research (Philadelphia, Pa.). Sep, 2008 | Pubmed ID: 19138972 Identification of Adducts Formed in the Reactions of 5'-acetoxy-N'-nitrosonornicotine with Deoxyadenosine, Thymidine, and DNA Chemical Research in Toxicology. Nov, 2008 | Pubmed ID: 18821782 Differential Expression of MicroRNAs in Early-stage Neoplastic Transformation in the Lungs of F344 Rats Chronically Treated with the Tobacco Carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone Carcinogenesis. Dec, 2008 | Pubmed ID: 18780894 Extensive Metabolic Activation of the Tobacco-specific Carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in Smokers Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology. Jul, 2008 | Pubmed ID: 18628430 Quantitation of Pyridylhydroxybutyl-DNA Adducts in Liver and Lung of F-344 Rats Treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and Enantiomers of Its Metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol Chemical Research in Toxicology. Jul, 2008 | Pubmed ID: 18570389 Formation of Formaldehyde Adducts in the Reactions of DNA and Deoxyribonucleosides with Alpha-acetates of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), and N-nitrosodimethylamine (NDMA) Chemical Research in Toxicology. Mar, 2008 | Pubmed ID: 18205321 Chemopreventive Agents Modulate the Protein Expression Profile of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone Plus Benzo[a]pyrene-induced Lung Tumors in A/J Mice Carcinogenesis. Mar, 2008 | Pubmed ID: 18192687 Indole-3-carbinol Inhibits 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone Plus Benzo(a)pyrene-induced Lung Tumorigenesis in A/J Mice and Modulates Carcinogen-induced Alterations in Protein Levels Cancer Research. Jul, 2007 | Pubmed ID: 17616712 Investigation of the Reaction of Myosmine with Sodium Nitrite in Vitro and in Rats Chemical Research in Toxicology. Mar, 2007 | Pubmed ID: 17291014 Quantitation of N-acetyl-S-(9,10-dihydro-9-hydroxy-10-phenanthryl)-L-cysteine in Human Urine: Comparison with Glutathione-S-transferase Genotypes in Smokers Chemical Research in Toxicology. Sep, 2006 | Pubmed ID: 16978029 Identification of Adducts Formed in the Reaction of 5'-acetoxy-N'-nitrosonornicotine with Deoxyguanosine and DNA Chemical Research in Toxicology. Mar, 2006 | Pubmed ID: 16544948 Identification of O2-substituted Pyrimidine Adducts Formed in Reactions of 4-(acetoxymethylnitrosamino)- 1-(3-pyridyl)-1-butanone and 4-(acetoxymethylnitros- Amino)-1-(3-pyridyl)-1-butanol with DNA Chemical Research in Toxicology. May, 2004 | Pubmed ID: 15144215 Stereoselective Metabolism and Tissue Retention in Rats of the Individual Enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), Metabolites of the Tobacco-specific Nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) Carcinogenesis. Jul, 2004 | Pubmed ID: 14988218 Endogenous 5-methylcytosine Protects Neighboring Guanines from N7 and O6-methylation and O6-pyridyloxobutylation by the Tobacco Carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone Biochemistry. Jan, 2004 | Pubmed ID: 14717610 Characterization of N-glucuronidation of the Lung Carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in Human Liver: Importance of UDP-glucuronosyltransferase 1A4 Drug Metabolism and Disposition: the Biological Fate of Chemicals. Jan, 2004 | Pubmed ID: 14709623 Stereospecific Deuterium Substitution Attenuates the Tumorigenicity and Metabolism of the Tobacco-specific Nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) Chemical Research in Toxicology. Jun, 2003 | Pubmed ID: 12807363 Identification of Adducts Formed by Pyridyloxobutylation of Deoxyguanosine and DNA by 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone, a Chemically Activated Form of Tobacco Specific Carcinogens Chemical Research in Toxicology. May, 2003 | Pubmed ID: 12755591 Effects of Benzyl Isothiocyanate and 2-phenethyl Isothiocyanate on Benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone Metabolism in F-344 Rats Carcinogenesis. Mar, 2003 | Pubmed ID: 12663513 Identification of Adducts Produced by the Reaction of 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanol with Deoxyguanosine and DNA Chemical Research in Toxicology. Feb, 2003 | Pubmed ID: 12588189 Benzyl Isothiocyanate: an Effective Inhibitor of Polycyclic Aromatic Hydrocarbon Tumorigenesis in A/J Mouse Lung Cancer Letters. Dec, 2002 | Pubmed ID: 12359355 Metabolism and Pharmacokinetics of N'-nitrosonornicotine in the Patas Monkey Drug Metabolism and Disposition: the Biological Fate of Chemicals. Oct, 2002 | Pubmed ID: 12228188 Inhibition of Lung Tumorigenesis in A/J Mice by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-L-cysteine and Myo-inositol, Individually and in Combination Carcinogenesis. Sep, 2002 | Pubmed ID: 12189187 Effects of Benzyl Isothiocyanate and Phenethyl Isothiocyanate on DNA Adduct Formation by a Mixture of Benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J Mouse Lung Carcinogenesis. Sep, 2002 | Pubmed ID: 12189184 Analysis of N- and O-glucuronides of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in Human Urine Chemical Research in Toxicology. Apr, 2002 | Pubmed ID: 11952341 Disposition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in Bile Duct-cannulated Rats: Stereoselective Metabolism and Tissue Distribution Carcinogenesis. Jan, 2002 | Pubmed ID: 11756238 En allmän metod för att upptäcka Nitrosamide bildning i In Vitro metabolismen av nitrosaminer genom cytokrom P450s Erik S. Carlson1,2, Pramod Upadhyaya2, Stephen S. Hecht2 1Department of Pharmacology, University of Minnesota, 2Masonic Cancer Center, University of Minnesota JoVE 56312 암 연구학
En allmän metod för att upptäcka Nitrosamide bildning i In Vitro metabolismen av nitrosaminer genom cytokrom P450s Erik S. Carlson1,2, Pramod Upadhyaya2, Stephen S. Hecht2 1Department of Pharmacology, University of Minnesota, 2Masonic Cancer Center, University of Minnesota JoVE 56312 암 연구학