Hollow Microneedle Arrays
Hollow Microneedle Arrays - Related Videos
08:19
Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
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Cited by 34 •
2012
This article details the construction of a multiplexed microneedle-based sensor. The device is being developed for in situ sampling and electrochemical analysis of multiple analytes in a rapid and selective manner. We envision clinical medicine and biomedical research uses for these microneedle-based sensors.
08:15
Polymeric Microneedle Array Fabrication by Photolithography
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Cited by 24 •
2015
Here, we present a protocol describing a mold-free fabrication process of the polymeric microneedles by photolithography.
08:26
Dissolving Microneedle Array Patches Manufactured By Solvent Casting Technique and Essential Characterization of Microneedle-Based Biomedical Devices
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2026
The present work aims to serve as a practical guide enabling researchers to prepare their own DMAP devices using the solvent-casting method, also known as micromolding, and to perform basic characterization.
06:25
Fabrication of a Master Mold for Microneedles with a Micron-sized Air-vent Hole
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2025
This article introduces a unique method for fabricating master molds with an air-vent hole to prevent air entrapment during viscous polymer casting, enabling the fabrication of gelatin microneedles with sharp tips. By reducing the casting volume of high-viscosity gelatin, thin-walled hollow pyramidal microneedles could also be fabricated.
02:58
Rodent Brain Microinjection Using a Quartz Microneedle
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2025
Source: Paolone, G., et al. Personalized Needles for Microinjections in the Rodent Brain. J. Vis. Exp. (2018).This video demonstrates a rodent brain microneedle injection using a quartz microneedle with holes. The microneedle is attached to a syringe and micropump to control the delivery rate. The needle with the injection solution is inserted into the brain with the delivery speed set at low. Once positioned, the delivery speed is increased. The needle is withdrawn after a brief pause.
FAQs
Once the array reaches the skin, its needles create temporary openings through the stratum corneum, the skin’s outer barrier. Delivery can then be driven by applied pressure or by diffusion, allowing material to move through the internal bores toward selected skin layers. This mechanism supports localized treatment while limiting tissue disruption.
Pressure-driven delivery uses an applied force to move drugs or vaccines through the bores, whereas diffusion relies on movement across the pathway without that driving pressure. This distinction matters because the two mechanisms provide different ways to direct material through the array toward targeted skin layers during transdermal treatment.
Bioengineering development focuses on three linked issues: fabrication of the microscale structures, dosing accuracy, and integration with wearable sensing systems. Fabrication affects whether the array provides the intended hollow pathways, while dosing accuracy influences delivery reliability. Wearable integration can connect delivery or sampling with ongoing measurement, guiding further design refinement.
A basic workflow begins by placing the array against skin so the needles cross the stratum corneum. For delivery, pressure or diffusion moves a selected drug or vaccine through the hollow channels into a targeted layer. For sampling, the array instead enables extraction of interstitial fluid. The platform therefore supports both inward delivery and outward fluid collection.
Interstitial fluid extraction provides a route to biomarker analysis without limiting the array to therapeutic delivery. In bioengineering studies, researchers can examine the sampled diagnostic fluid after it is extracted through the hollow channels. This application broadens the platform from localized therapy to minimally invasive collection of biological information for analysis.
Their microscale format can reduce pain and improve patient acceptance while enabling localized delivery, controlled release, or interstitial-fluid sampling. These capabilities make the arrays relevant to transdermal drugs and vaccines as well as diagnostic approaches. Ongoing research also examines how they can be integrated with wearable sensing systems for combined delivery and measurement.