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JoVE Journal Neuroscience
Intracerebroventrikulær Injektion af amyloid-p-peptider i normale mus til Akut Fremkald Alzheimer-lignende kognitive mangler
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Intracerebroventrikulær Injektion af amyloid-p-peptider i normale mus til Akut Fremkald Alzheimer-lignende kognitive mangler

Article DOI: 10.3791/53308-v • 08:01 min • March 16th, 2016
March 16th, 2016 •
1,2, 1, 1,3, 1,4, 1,4
1Center for Neuro-Medicine, Korea Institute of Science and Technology, 2Research Institute, GoshenBiotech, Inc., 3Department of Chemical and Biological Engineering, Princeton University, 4Biological Chemistry Program, Korea University of Science and Technology

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Den amyloid-β (Ap) -injiceret dyremodel muliggør administration af en defineret mængde og art af Ap fragmenter og reducerer individuelle forskelle inden for hver studiegruppe. Denne protokol beskriver intracerebroventrikulær (ICV) injektion af Ap uden stereotaktiske instrumenter, muliggør produktionen af ​​Alzheimer-lignende adfærdsmæssige abnormiteter i normale mus.

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Neuroscience Alzheimers sygdom amyloid-beta (Ap) intracerebroventrikulær (ICV) injektion adfærd tests kognitive mangler læring og hukommelse
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