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Journal / Medicine / 低酸素/SU5416モデルを用いたマウスにおける肺高血圧の誘導と特徴づけ…
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低酸素/SU5416モデルを用いたマウスにおける肺高血圧の誘導と特徴づけ
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低酸素/SU5416モデルを用いたマウスにおける肺高血圧の誘導と特徴づけ

Article DOI: 10.3791/59252-v • 07:10 min • June 3rd, 2020
June 3rd, 2020 •
1, 2, 1, 1
1Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, 2Phospholamban Foundation

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このプロトコルは、低酸素症への暴露およびVEGF受容体拮抗薬の注射に基づくマウスにおける肺高血圧(PH)の誘導について説明する。動物は、プロトコルの開始から3週間後にPHおよび右心室(RV)肥大を発症する。モデルの機能的および形態的特徴付けも提示される。

Tags

医学、問題160、低酸素、SU5416、Sugen、肺高血圧、PH、右心室圧、肺血管リモデリング、右心室リモデリング
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