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JoVE Journal Cancer Research

Un modèle murin de résection orthotopique du cancer du pancréas

Longitudinal Morphological and Physiological Monitoring of Three-dimensional Tumor Spheroids Using Optical Coherence Tomography

Journal (Cancer Research)

Longitudinal Morphological and Physiological Monitoring of Three-dimensional Tumor Spheroids Using Optical Coherence Tomography

Detection of a CDH1 Rare Transcript Variant in Fresh-frozen Gastric Cancer Tissues by Chip-based Digital PCR

Journal (Cancer Research)

Detection of a CDH1 Rare Transcript Variant in Fresh-frozen Gastric Cancer Tissues by Chip-based Digital PCR

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Un modèle murin de résection orthotopique du cancer du pancréas

Article DOI: 10.3791/61726-v • 07:17 min • September 24th, 2020

September 24th, 2020 •

Tony C. Y. Pang^1,2,4,5, Zhihong Xu^1,2, Alpha Raj Mekapogu^1,2, Srinivasa Pothula^1,2, Therese M. Becker³, David Goldstein¹, Romano C. Pirola^1,2, Jeremy S. Wilson^1,2, Minoti V. Apte^1,2

¹Pancreatic Research Group, South Western Sydney Clinical School, University of New South Wales, ²Ingham Institute for Applied Medical Research, ³Centre for Circulating Tumour Cell Diagnostics and Research, Ingham Institute for Applied Medical Research, ⁴Surgical Innovations Unit, Westmead Hospital, ⁵Westmead Clinical School, University of Sydney

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Dans le contexte clinique, les patients atteints d’un cancer pancréatique localisé subiront une pancréatectomie suivie d’un traitement adjuvant. Ce protocole rapporté ici vise à établir une méthode sûre et efficace de modélisation de ce scénario clinique chez les souris nues, par l’implantation orthotopic du cancer pancréatique suivie de pancreatectomy et de splenectomy distaux.

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Recherche sur le cancer Numéro 163 Adénocarcinome canalaire pancréatique (ACPE) Traitement adjuvant Thérapie néoadjuvante Pancréatectomie Modèle murin orthotopique Cellules étoilées pancréatiques

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