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JoVE Journal Cancer Research

Cultivo de organoides del cáncer de vejiga como herramientas de medicina de precisión

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Cultivo de organoides del cáncer de vejiga como herramientas de medicina de precisión

Article DOI: 10.3791/63192-v • 08:39 min • December 28th, 2021

December 28th, 2021 •

Patrick B. Thomas^1,2,3,4, Mahasha P. J. Perera^1,2,3,4,5, Saeid Alinezhad^1,4, Andre Joshi^1,4,5, Paria Saadat^1,2, Clarissa Nicholls^1,2, Caitlin P. Devonport^1,2,4, Alivia R. Calabrese^1,2,3,4, Abby R. Templeton^1,2,3, Jack R. Wood^1,2, Nathan J. Mackenzie^1,2, Penny L. Jeffery^1,2,3,4, Ian Vela*^1,2,3,4,5, Elizabeth D. Williams*^1,2,3,4

¹School of Biomedical Sciences, Faculty of Health, Queensland University of Technology (QUT) at Translational Research Institute, ²Queensland Bladder Cancer Initiative (QBCI), ³Centre for Personalised Analysis of Cancers (CPAC), ⁴Australian Prostate Cancer Research Centre - Queensland, ⁵Department of Urology, Princess Alexandra Hospital

* These authors contributed equally

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Los organoides derivados del paciente (DOP) son una herramienta poderosa en la investigación traslacional del cáncer, que refleja tanto la heterogeneidad genética y fenotípica de la enfermedad como la respuesta a las terapias personalizadas contra el cáncer. Aquí, se detalla un protocolo consolidado para generar DOP de cáncer de vejiga primario humano en preparación para la evaluación de análisis fenotípicos y respuestas a medicamentos.

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Investigación del cáncer número 178

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