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The Mexican Tetra, Astyanax mexicanus is an excellent model organism to study the developmental and genetic basis of evolution. This species of fish co…
Cell-free expression (CFE) systems are a collection of methods that use extracted cellular machinery to mimic core functions of cells, such as transcription and translati…
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Access to the complex and intricate structures of the brain is becoming critical for the study and understanding of neurological disorders. In this perspective, non-invas…
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Cancer is one of the most severe diseases with poor prognosis and survival, especially in patients with advanced disease. Cancer classification plays a vital role in the …
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Cancer is a complex disease that is among the top three diseases that cause death all over the world. This disease carries the physiological, biochemical, pathological, a…
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New and novel crop improvement methods are necessary to achieve continuous yield gains in crop species. Novel crop improvement methods include improvements in crossing te…
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In eukaryotic cells, compartmentalization of diverse cellular activities occurs in membrane-bound organelles in a spatially and temporally controlled manner. Earlier repo…
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Color is an essential trait in the plant kingdom that can be found in every organ. The most popular usage of color is to plant flowers with different colors in the cosmet…
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Repeated DNA sequences have a wide range of clinical and forensic applications. However, to this day, significant limitations of the technology remain constraints that hi…
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MicoRNAs as tiny intracellular regulatory transcripts, take a part in all of the life processes. A great part of scientific literature presents evidence confirming that m…
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Cellular identity, environment, stimuli, and physiological rhythms all require a static genome to respond dynamically, and sometimes reversibly while preserving the under…
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microRNAs are small non-coding RNA molecules that operate as negative regulators of gene expression to regulate various biological functions. As researchers discover nove…
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Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the developed world. Short of treating pathologic neovascularization that sometim…
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Motor skill learning or procedural learning unlike declarative memory systems requires time and practice to assimilate into the brain. Neural mechanisms of skill learning…
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Topoisomerases are enzymes that play imperative roles in replication, transcription, chromosome remodeling by managing the topology of DNA. To do so, topoisomerase genera…
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Neurometabolic disorders belong to a rapidly expanding group of inherited inborn errors of metabolism in which neurological manifestations predominate. The gamut of neuro…
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Over the past decade, there has been significant progress in developing therapeutic options for several ocular diseases such as diabetic retinopathy,  inherited reti…
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Oxidative stress is an imbalance between oxidant and antioxidant molecules, which is usually associated with oxidative damage to biomolecules and an altered mitochondrial…
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The genetic basis of a complex of quantitative traits has been one of the most enduring challenges in modern biology.  To discern the genetic basis of these traits, …
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Following fertilization, a new life begins in the form of a single cell zygote. Initially, the zygote solely utilizes maternally provided mRNAs and proteins to support ea…
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Methods collected here focus on techniques to analyze the activity of cells involved in bone remodeling in vivo as well in vitro.

Methods describe techniqu…
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We have entered the golden age of immunotherapy, one in which truly curative therapies for currently intractable diseases are possible, but to realize this vision we must…
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A key aspect of genome engineering is to be able to develop methods that are simple and robust, but also easily adapted to various biological systems. In the last decade,…
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Stem cells possess unique characteristics of pluripotency and self-renewal abilities. Theoretically, human pluripotent stem cells (hPSCs) have the potential to be program…
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Jacques Monod stated that the study of bacterial cell growth is the basic microbiology method (Monod 1949). Each phase of growth defined more than 70 years is of new inte…
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Sexual reproduction requires creating haploid gametes from diploid parents through meiosis. Prior to meiotic cell divisions, homologous chromosomes pair and recombine to …
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Genomic stability is critical for life. Repair of DNA when damaged is vital for preserving the information stored in the genome, and failure to accurately repair DNA dama…
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In living cells, meters of DNA must be significantly compacted to fit inside of the tiny compartment in the cell. In eukaryotic cells, the first level of chromosomal comp…
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A severe threat to the global health is antimicrobial resistance (AMR). Antimicrobial resistance will lead to an estimated death of around 10 million people annually due …
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The full name of Cas13 is CRISPR-associated protein 13, which is a Class II type VI CRISPR-Cas RNA endonuclease. This new type of enzyme was originally found in bacteria …
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Chlamydomonas reinhardtii is a single-celled green algae used as a model organism for both plants and animals to study various cellular functions. The objec…
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In this themed collection on functional nucleic acids, we seek to highlight the rich diversity of nucleic acid structures, both RNA and DNA, that engage in a function, wh…

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