Open Globe Injury
Open Globe Injury - Related Videos
07:27
Anterior Segment Organ Culture Platform for Tracking Open Globe Injuries and Therapeutic Performance
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Cited by 1 •
2021
Open globe eye injuries may go untreated for multiple days in rural or military-relevant scenarios, resulting in blindness. Therapeutics are needed to minimize loss of vision. Here, we detail an organ culture open globe injury model. With this model, potential therapeutics for stabilizing these injuries can be properly evaluated.
14:58
A Simplified Technique for In situ Excision of Cornea and Evisceration of Retinal Tissue from Human Ocular Globe
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Cited by 7 •
2012
The paper describes a simplified technique to excise corneal and to eviscerate retinal tissues from the ocular globe of human cadaveric donors. The technique described here will help to excise good quality tissues to be used for transplantation, surgical or research purposes without damaging other tissues of the ocular globe.
05:15
Grossing of Non-neoplastic Globes, Including Fetal Eyes
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Cited by 1 •
2025
Thorough grossing and standardized sectioning of non-neoplastic globes are important for obtaining high-quality reproducible histopathologic sections. Guidelines for a standardized grossing of adult and fetal non-neoplastic globes are provided herein. Different options for globe sectioning are demonstrated and discussed, including criteria for case-based decision-making.
07:28
Controlled Cervical Laceration Injury in Mice
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Cited by 17 •
2013
A novel technique to create a reproducible in vivo model of cervical spinal cord laceration injury in the mouse is described. This technique is based on spine stabilization by fixation of the cervical facets and laceration of the spinal cord using an oscillating blade with an accuracy of ±0.01 mm.
04:19
A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury
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Cited by 16 •
2017
Athletes absorb several hundred mild traumatic brain injuries (mTBI)/concussions every year; however, the consequence of these on the brain is poorly understood. Therefore, an animal model of single and repetitive mTBI that consistently replicates clinically relevant symptoms provides the means to advance the study of mTBI and concussion.
FAQs
The breached eyewall permits deformation of the globe and loss of intraocular fluid, which can disturb the eye’s normal structure. As the globe changes shape, intraocular tissues may become displaced or damaged. These mechanical effects explain why protecting the injured eye and restoring closure are important for limiting additional harm after the initial trauma.
Tissue displacement or damage indicates that the injury affects more than the outer wound itself. Changes within the globe can compromise the organization needed for normal vision and may complicate reconstruction. Recognizing this internal involvement helps connect the external eyewall failure with the potential severity of visual consequences and the need for surgical repair.
Biomechanical models reproduce the way the eye wall fails when trauma overwhelms its protective structure. By representing deformation and breach of the cornea or sclera, these models provide a controlled framework for examining injury behavior. In bioengineering, they support evaluation of repair concepts without relying only on observations from severe clinical trauma.
Immediate protection of the injured eye and urgent surgical closure are the central priorities. Protection helps limit further deformation, fluid loss, and displacement of intraocular tissues, while closure restores the barrier formed by the cornea or sclera. Together, these steps aim to prevent additional damage and preserve the possibility of visual recovery.
Ocular biomaterials and tissue-engineered grafts are developed to support reconstruction of the damaged eye wall and promote healing. Their relevance lies in addressing both structural repair and recovery of the injured tissue environment. Bioengineering research uses these approaches to seek safer reconstruction strategies for severe ocular trauma.
Surgical repair devices are designed as engineering solutions for closing or stabilizing the injured globe during reconstruction. Their development is informed by the mechanical disruption caused by trauma and by the need to limit further harm. Researchers can assess such devices alongside biomaterials, grafts, and biomechanical models when improving repair strategies.