Intraarterial Delivery
Intraarterial Delivery - Related Videos
05:10
Intrarenal Drug Delivery in Rats: A Method to Deliver Therapeutic Drugs in Rat Kidney via Intra-arterial Injection
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2023
In this video, we demonstrate intra-renal drug administration in rats via the renal artery. This method is beneficial in improving drug targeting, drug potency, and minimizing systemic toxicity.
07:00
Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis
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Cited by 43 •
2016
This manuscript provides the detailed procedure of intra-iliac artery (IIA) injection, a technique to deliver cancer cells specifically to hind limb tissues including bones to establish experimental bone metastases. Although initially established with breast tumor models, this protocol can be easily extended to other cancer types.
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Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia
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Cited by 12 •
2020
A method for delivering neural stem cells, adaptable for injecting solutions or suspensions, through the common carotid artery (mouse) or external carotid artery (rat) after ischemic stroke is reported. Injected cells are distributed broadly throughout the brain parenchyma and can be detected up to 30 d after delivery.
13:32
Videomorphometric Analysis of Hypoxic Pulmonary Vasoconstriction of Intra-pulmonary Arteries Using Murine Precision Cut Lung Slices
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Cited by 29 •
2014
Hypoxic pulmonary vasoconstriction (HPV) is an important physiological phenomenon by which at alveolar hypoxia lung perfusion is matched to ventilation. The major vascular segment contributing to HPV is the intra-acinar artery. Here, we describe our protocol for the analysis of HPV of murine pulmonary vessels with diameters of 20-100 μm.
03:42
Targeted Substance Delivery to the Mouse Brain via Infusion into the Internal Carotid Artery
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2025
Source: Leda, A. R., et al. Mouse Microsurgery Infusion Technique for Targeted Substance Delivery into the CNS via the Internal Carotid Artery. J. Vis. Exp. (2017)This video demonstrates a microsurgical procedure designed to facilitate the targeted infusion of a test substance into the brain via the internal carotid artery (ICA). The procedure involves precise suturing and vascular manipulation to temporarily restrict blood flow, ensuring controlled delivery. A capillary tube is inserted into...
FAQs
Blood flow determines how effectively the administered agent reaches the tumor region. Once the agent enters an artery supplying the tumor, circulation transports it through that target territory, while the delivery design controls the rate and concentration presented to the tissue. These variables are important because they influence whether treatment can emphasize tumor exposure without equally increasing exposure in surrounding tissues.
Compared with administration that distributes a therapy more broadly through the circulation, intraarterial delivery is intended to concentrate treatment in a selected vascular territory. The approach may increase exposure at the tumor while reducing distribution to surrounding tissues. This regional emphasis makes the method useful for investigating whether localization can improve the precision of cancer treatment.
Catheter placement establishes the route between the therapeutic agent and the artery supplying the tumor. The selected artery determines the region exposed, whereas the administration rate and concentration shape treatment conditions within that region. In cancer studies, these linked factors provide a controllable framework for testing regional chemotherapy and other targeted agents.
A basic intraarterial delivery workflow includes guiding a catheter into an artery associated with the tumor, administering the chosen agent, and allowing arterial blood flow to carry it through the target region. The agent and delivery design depend on the research objective. Studies may evaluate chemotherapy, embolization, imaging agents, or experimental agents rather than applying one universal protocol.
Researchers may select this approach when a study requires treatment or agent delivery focused on a tumor’s vascular territory rather than broad distribution. Its applications include regional chemotherapy, embolization, and administration of imaging or experimental agents. This flexibility allows cancer research teams to examine therapeutic strategies as well as methods for visualizing or testing interventions near the tumor.
Intraarterial delivery can support assessment of how a therapy reaches a tumor region, how controlled administration affects local exposure, and whether regional treatment may limit distribution to surrounding tissues. These observations contribute to the development of more precise treatment strategies. The specific outcome depends on the selected agent, delivery design, and purpose of the cancer research study.