Engineering Design

Engineering design is the systematic process of defining a need and developing solutions that satisfy technical, economic, safety, and user requirements. It works through an iterative cycle in which engineers translate requirements into specifications, generate and evaluate concepts, build models or prototypes, and use testing and analysis to refine performance. This process connects scientific principles with materials, manufacturing methods, computation, and project constraints. Engineering design supports products, structures, systems, and technologies across fields, while documentation and evaluation help teams compare alternatives, manage trade-offs, and produce reliable solutions to real-world problems.

Engineering Design - Related Videos

Research

JoVE Journal - Biology
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Mouse Genome Engineering Using Designer Nucleases

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Cited by 14 •

2014

Designer nucleases such as zinc finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs) can be used to modify the genome of mouse preimplantation embryos by triggering both the nonhomologous end joining (NHEJ) and homologous recombination (HR) pathways. These advances enable the rapid generation of mice with precise genetic modifications.

Research

JoVE Journal - Bioengineering

Design of a Biaxial Mechanical Loading Bioreactor for Tissue Engineering

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Cited by 24 •

2013

We designed a novel mechanical loading bioreactor that can apply uniaxial or biaxial mechanical strain to a cartilage biocomposite prior to transplantation into an articular cartilage defect.

Engineering Platform and Experimental Protocol for Design and Evaluation of a Neurally-controlled Powered Transfemoral Prosthesis

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Cited by 15 •

2014

Neural-machine interfaces (NMI) have been developed to identify the user's locomotion mode. These NMIs are potentially useful for neural control of powered artificial legs, but have not been fully demonstrated. This paper presented (1) our designed engineering platform for easy implementation and development of neural control for powered lower limb prostheses and (2) an experimental setup and protocol in a laboratory environment to evaluate neurally-controlled artificial legs on patients with...

Design and Construction of Artificial Extracellular Matrix (aECM) Proteins from Escherichia coli for Skin Tissue Engineering

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Cited by 6 •

2015

Recombinant technologies have enabled material designers to create novel artificial proteins with customized functionalities for tissue engineering applications. For example, artificial extracellular matrix proteins can be designed to incorporate structural and biological domains derived from native ECMs. Here, we describe the construction and purification of aECM proteins containing elastin-like repeats.

Education

JoVE Science Education - Advanced Biology

An Overview of Genetic Engineering

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2023

Genetic engineering – the process of purposefully altering an organism’s DNA – has been used to create powerful research tools and model organisms, and has also seen many agricultural applications. However, in order to engineer traits to tackle complex agricultural problems such as stress tolerance, or to realize the promise of gene therapy for treating human diseases, further advances in the field are still needed. Important considerations include the safe and efficient delivery of genetic...

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