Name: hydrogen bonding and dna stability
Uploaded: 2025-05-22T09:05:54.000Z
Duration: 1 min 4 s
Channel: JoVE

K12 Standards

Florida Department of Education

High School

Physical Science

SC.912.P.8

SC.912.P.8.6

Hydrogen Bonds

Uma ligação de hidrogênio é uma atração eletrostática intermolecular entre um átomo de hidrogênio e um átomo eletronegativo com um par de elétrons isolado.
Em uma molécula polar, como fluoreto de hidrogênio ou HF, amônia ou NH3 e água ou H2O, o átomo de flúor, nitrogênio ou oxigênio é mais eletronegativo que o hidrogênio.
O átomo mais eletronegativo atrai pares de elétrons de ligação com mais força do que o hidrogênio. Isso resulta em distribuição desigual de elétrons na ligação, dando ao átomo eletronegativo uma carga parcial negativa e ao átomo de hidrogênio uma carga parcial positiva.
A carga parcial positiva no átomo de hidrogênio permite atrair pares de elétrons não ligados de um átomo eletronegativo em sua vizinhança, formando uma ligação de hidrogênio.
As ligações de hidrogênio fornecem estabilidade estrutural a várias moléculas biológicas, incluindo o DNA.

ligações de hidrogênio

Uma ligação de hidrogênio é formada quando um átomo de hidrogênio fracamente positivo, já ligado a um átomo eletronegativo (por exemplo, o oxigênio na molécula de água), é atraído por outro átomo eletronegativo de outra molécula polar, como a água (H_2O), o fluoreto de hidrogênio (HF) ou a amônia (NH_3). A enorme diferença de eletronegatividade entre o átomo de H (2,1) e o átomo ao qual está ligado (4,0 para um átomo de F, 3,5 para um átomo de O ou 3,0 para um átomo de N), em combinação com o tamanho muito pequeno de um átomo de H, resulta em uma distribuição desigual de cargas entre o átomo de hidrogênio e o átomo eletronegativo. Isso faz com que o átomo de hidrogênio se torne parcialmente positivo, e o átomo eletronegativo se torne parcialmente negativo. Assim, moléculas com as partes F-H, O-H ou N-H são fortemente atraídas por partes semelhantes de moléculas próximas, formando uma atração dipolo-dipolo particularmente forte chamada ligação de hidrogênio.

As ligações de hidrogênio têm um efeito pronunciado nas propriedades de líquidos e sólidos. Por exemplo, o ponto de fusão e o ponto de ebulição da metilamina (CH_3NH_2) são maiores do que os do etano (CH_3CH_3), embora ambos sejam semelhantes em tamanho e massa. Ao contrário do etano, a metilamina possui um grupo NH que permite a formação de ligações de hidrogênio e aumenta as forças intermoleculares entre as moléculas, o que acaba elevando seus pontos de fusão e de ebulição.

As ligações de hidrogênio são comuns no mundo natural, como no DNA, que contém informações genéticas e é encontrado em todos os organismos. Cada par de bases do DNA é formado por ligações de hidrogênio, através de três ligações de hidrogênio. Esse emparelhamento de bases complementar contribui para a forma e estabilidade da estrutura de dupla hélice do DNA.

Este texto é adaptado de <a href="https://openstax.org/books/anatomy-and-physiology-2e/pages/">Openstax, Anatomy and Physiology 2e, Section 2.2: Chemical Bonds</a> and <a href="https://openstax.org/books/anatomy-and-physiology-2e/pages/">Openstax, Chemistry 2e, Section 10.1: Intermolecular Forces </a>

Ligações de Hidrogênio

Uma ligação de hidrogênio é formada quando um átomo de hidrogênio fracamente positivo já ligado a um átomo eletronegativo (por exemplo, o oxigênio na molécula de água) ...

Education

JoVE Core

Anatomy and Physiology

Anatomia e Fisiologia

Unit 1

Unidade 1

Fundamentals of Chemistry

Fundamentos da Química

KEY TERMS AND CONCEPTS

TERMOS-CHAVE E CONCEITOS

hydrogen bonding and dna stability

Hydrogen bonding helps explain why some molecules stick together more strongly than others. A hydrogen bond forms when a weakly positive hydrogen atom, already bonded to an electronegative atom, is attracted to another electronegative atom on a nearby polar molecule. Common examples include water, hydrogen fluoride, and ammonia.

This attraction happens because hydrogen has a much lower electronegativity than atoms such as fluorine, oxygen, and nitrogen. The electronegativity difference, along with hydrogen’s very small size, creates an uneven charge. The hydrogen becomes partially positive, and the electronegative atom becomes partially negative. Molecules with F-H, O-H, or N-H groups can then form a strong dipole-dipole attraction called a hydrogen bond.

Hydrogen bonding can change the properties of liquids and solids. For example, methylamine has a higher melting point and boiling point than ethane, even though the two molecules are similar in size and mass. The difference is that methylamine has an -NH group, which lets it form hydrogen bonds and strengthens the intermolecular forces between its molecules.

Hydrogen bonds are also important in living things. DNA, which carries genetic information in every organism, relies on hydrogen bonding between base pairs. Each base pair is held together by three hydrogen bonds. This complementary pairing helps give DNA its double helix shape and supports its stability.

Hydrogen Bonding and DNA Stability

what is matter?

Matter, Mass, and Weight Basics

Matter is the substance that makes up the universe, from a grain of sand to a star. Scientists define matter as anything that occupies space and has mass. Mass is the amount of matter in an object, while weight depends on gravity. Mass stays the same whether an object is on Earth or in the zero-gravity environment of outer space. Weight changes when gravity changes. An object weighs more where gravity is stronger and less where gravity is weaker. A piece of cheese that weighs a pound on Earth...

the periodic table and organismal elements

the-periodic-table-and-organismal-elements

Organismal Elements in the Periodic Table

The periodic table helps identify the elements that make up living organisms. Biology groups these as organismal elements because they are the chemical building blocks of life. These elements are found in different amounts in the body. Some are present in large quantities, while others are needed only in small amounts. The video connects the periodic table to the elements that organisms actually use. Understanding organismal elements helps students link chemistry to biology. It shows how...

atomic structure

From Atomos to the Modern Atom

Atoms are the tiny building blocks of matter, and ideas about them go back to the Greek philosopher Democritus. He suggested that everything on Earth is made of atomos, a Greek word meaning "indivisible." That idea later led to the modern word atom. In the 19th century, John Dalton developed an atomic theory that is still largely correct today. He proposed five key ideas. All matter is made of tiny particles called atoms. Atoms of the same element are alike, and atoms of different elements are...

chemical symbols

Chemical Symbols and Element Names

Chemical symbols are short abbreviations that stand for an element or a single atom of that element. Mercury, for example, has the symbol Hg. The same symbol can point to one atom of mercury in the microscopic domain or to a sample labeled as many atoms of mercury in the macroscopic domain. Many symbols come from the element’s common name. Others are shortened from a name in another language. Most chemical symbols use one or two letters. For a few elements with atomic numbers above 112,...

atomic number and mass number

Atomic Identity, Mass, and Isotopes

Atomic identity depends on the number of protons in the nucleus, and mass depends on protons and neutrons together. The number of protons is the atomic number, or Z. It defines the element. For example, any atom with six protons is carbon, no matter how many neutrons or electrons it has. In a neutral atom, the number of protons equals the number of electrons. Because of that, the atomic number also tells you the number of electrons in the atom. The total number of protons and neutrons is...

atomic weight

Atomic Mass and Mole Calculations

Atomic mass and mole calculations help explain how much matter is in atoms and compounds. Protons and neutrons have about the same mass, about 1.67 × 10 -24 grams. Scientists define that mass as one atomic mass unit, or amu, also called one Dalton. Electrons are much lighter than protons. They weigh only 9.11 × 10 -28 grams, or about 1/1800 of an atomic mass unit. Because of that small mass, electrons do not add much to an element’s overall atomic mass. When chemists calculate atomic mass,...

isotopes and radioisotopes

Radioisotopes in Medicine and Imaging

Radioisotopes are unstable isotopes that can be used to study the body and treat disease. An isotope is an atom of the same element that has a different mass because it contains a different number of neutrons. It still has the same number of protons, so it remains chemically identical. English chemist Frederick Soddy explained this idea in the early 1900s and later received the Nobel Prize in Chemistry in 1921. Some isotopes have more neutrons than usual and are called heavy isotopes. These...

electron behavior

Electron Shells and Discovery

Electrons are negatively charged subatomic particles that stay near the positively charged nucleus of an atom. They occupy spaces linked to energy levels called shells. They are also arranged into subshells and orbitals within each shell. An electron’s shell shows its general energy level. Electrons closer to the nucleus have less energy, while electrons farther away have more energy. The outer shells have more space, so they can hold more electrons than the inner shells. Subshells describe...

introduction to chemical bonds

How Atoms Bond to Reach Stability

Atoms bond to become more stable, and their outermost electrons play the biggest role in that process. The inner electron shell can hold two electrons. The next two shells can each hold eight electrons. This is called the octet rule. It states that, except for the innermost shell, atoms are most stable when their valence shell, or outer shell, has eight electrons. When atoms do not have enough electrons to fill that outer shell, they form chemical bonds with other atoms. A chemical bond is the...

ionic bonds

Ionic Bonds and Charge Transfer

Ionic bonds form when atoms transfer electrons and become charged particles. A positive ion and a negative ion attract each other because opposite charges pull together. This type of bonding helps explain how some substances are held together. In many cases, an atom loses one or more electrons, while another atom gains them. The atom that loses electrons becomes a cation, which is a positively charged ion. The atom that gains electrons becomes an anion, which is a negatively charged ion. The...

covalent bonds

Polar and Nonpolar Covalent Bonds

Covalent bonds form when atoms share electrons to fill their valence shells. The way those shared electrons are pulled depends on electronegativity, which is an atom's tendency to attract electrons in a bond. That difference also helps explain why some molecules are polar and others are nonpolar. Atoms with similar electronegativities form nonpolar covalent bonds. In these bonds, electrons are shared equally, so there is no charge across the molecule. When two atoms have different...

hydrogen bonds

Hydrogen bonding helps explain why some molecules stick together more strongly than others. A hydrogen bond forms when a weakly positive hydrogen atom, already bonded to an electronegative atom, is attracted to another electronegative atom on a nearby polar molecule. Common examples include water, hydrogen fluoride, and ammonia. This attraction happens because hydrogen has a much lower electronegativity than atoms such as fluorine, oxygen, and nitrogen. The electronegativity difference, along...

ions, molecules, and compounds

Atomic Charges, Bonds, and Compounds

Atoms can gain or lose electrons during chemical reactions and become ions. An ion is an atom with an electrical charge. This charge is positive or negative, and it often helps the atom reach a full valence shell. Some atoms are more likely to donate electrons, while others are more likely to accept them. Potassium is one example. It has atomic number 19 and one electron in its valence shell, so it is likely to donate that electron and become a slightly positive ion called a cation. Fluorine...

states of matter

Solids, Liquids, Gases, and Plasma

Solids, liquids, gases, and plasma are the main forms of matter described here. Solids are rigid and keep a definite shape. Liquids flow and take the shape of their container, although gravity gives the surface a flat or slightly curved top. Solids and liquids also have volumes that stay nearly the same even when pressure changes. Gases behave differently from solids and liquids. A gas takes both the shape and the volume of its container. In matter with this behavior, the particles are far...

colloids and suspensions

Suspensions, Sedimentation, and Colloids

Suspensions and colloids are two common kinds of mixtures seen in everyday life. Mud and water, flour and water, and tempera paint are suspensions. These mixtures are heterogeneous, which means their particles are not spread out evenly. The particles are relatively large and can be seen with the naked eye or a magnifying glass. Suspension particles make mixtures cloudy, and they settle out after mixing. The settling of particles in a suspension is called sedimentation. A blood test can measure...

introduction to chemical reactions

Chemical Reaction Basics and Equilibrium

Chemical reactions start with reactants and end with products. Reactants are the substances that enter a reaction, and products are the new substances that form. For example, sodium and chloride ions are the reactants in the formation of table salt. Chemical reactions follow the law of conservation of mass. Matter is not created or destroyed during the reaction. That means the atoms and elements in the reactants are still present in the products, and nothing new appears in the products that...

types of chemical reactions: anabolic and catabolic

types-of-chemical-reactions-anabolic-and-catabolic

Anabolism, Catabolism, and ATP Use

Anabolism and catabolism are the two main kinds of metabolic reactions in the body. Metabolism is the total set of anabolic and catabolic reactions that keep life running. These reactions follow the first law of thermodynamics, which says energy cannot be created or destroyed. It can only change form. Anabolism builds larger, more complex molecules from smaller ones. These anabolic, or biosynthesis, reactions need energy in the form of ATP. They join monosaccharides into polysaccharides, fatty...

types of chemical reactions: exchange and reversible

types-of-chemical-reactions-exchange-and-reversible

Electron Transfer and Chemical Equilibrium

Exchange reactions and reversible reactions are two important ideas in chemistry. In an exchange reaction, synthesis and decomposition happen at the same time. Chemical bonds are both formed and broken. These reactions can absorb chemical energy, store it, and release it. A special type of exchange reaction is the oxidation-reduction reaction, or redox reaction. In a redox reaction, electrons move from one compound to another. The electrons often come from hydrogen atoms, which contain one...

energy transfer in chemical reactions

Chemical Energy and Reaction Types

Chemical reactions depend on energy transfer, chemical bonds, and the way matter collides. A reaction needs enough energy for particles to meet with the right force and precision. That energy can break old bonds and help form new ones. Kinetic energy is the energy of motion. A person lifting a brick uses kinetic energy to move the brick into place on a wall. Once the wall is built, it stores potential energy, which is the energy of position or structure. If the wall falls, that stored energy...

factors influencing the rate of chemical reactions

factors-influencing-the-rate-of-chemical-reactions

Chemical Reaction Rates and Catalysts

Chemical reaction rates depend on how often particles collide and whether those collisions have enough energy to start a reaction. That starting energy is called activation energy. Factors that affect reaction rate either lower that energy or make successful collisions more likely. Concentration and pressure can speed reactions up because they put more particles in the same space. When more particles are present, they are more likely to bump into one another. Chemists can also increase...

acids, bases and neutralization reactions

How pH Affects Cells and Digestion

Acids, bases, and pH help control how cells and body systems work. In biology, pH can strongly affect enzymes, proteins, and nucleic acids. Enzymes work best within a certain pH range, and pH changes can alter their structure or denature them, which changes how they function. Acids release hydrogen ions, or H+, in solution. A hydrogen ion is a proton, so it is very reactive in chemical reactions. Strong acids release all of their H+ in water and ionize completely. Hydrochloric acid (HCl) is a...

key terms and concepts

Learn how hydrogen bonding forms, why it strengthens intermolecular forces, and how it helps raise boiling points and stabilize DNA.

Hydrogen Bonding and DNA Stability | JoVE K12

anatomy and physiology

O JoVE Core Anatomia e Fisiologia apresenta detalhes anatômicos e fisiológicos do corpo humano em animações  abrangentes, claras e envolventes. Esta coleção de vídeos se concentra nas estruturas, componentes, funções e requisitos do corpo humano. É complementada por vídeos de cientistas em ação que demonstram a aplicação desse conhecimento em instalações médicas e de pesquisa do mundo real.

Classifying Matter by State

Chemistry is the study of matter and the changes it undergoes. Matter is anything that has mass and occupies space. Matter is all around us; the air, ...

States of Matter

Solids, liquids, and gases are the three states of matter commonly found on Earth. A solid is rigid and possesses a definite shape. A liquid flows and ...

States of Matter and Phase Changes

The internal energy of a substance&#8212;the total kinetic energy of all its molecules and the potential energy of their associated forces&#8212;depends ...

molecular-comparison-of-gases-liquids-and-solids

Molecular Comparison of Gases, Liquids, and Solids

Particles in a solid are tightly packed together (fixed shape) and often arranged in a regular pattern; in a liquid, they are close together with no ...

Differentiate between physical and chemical properties and physical and chemical changes of matter.

SC.912.P.8.1

physical-and-chemical-properties-of-matter

Physical and Chemical Properties of Matter

The characteristics that enable us to distinguish one substance from another are called properties.

Physical Properties of Matter

A physical property is ...

Phase Transitions

Whether solid, liquid, or gas, a substance&#39;s state depends on the order and arrangement of its particles (atoms, molecules, or ions). Particles in the ...

phase-transitions-vaporization-and-condensation

Phase Transitions: Vaporization and Condensation

The physical form of a substance changes on changing its temperature. For example, raising the temperature of a liquid causes the liquid to vaporize ...

Vapor Pressure

When a liquid vaporizes in a closed container, gas molecules cannot escape. As these gas phase molecules move randomly about, they will occasionally ...

Clausius-Clapeyron Equation

The equilibrium between a liquid and its vapor depends on the temperature of the system; a rise in temperature causes a corresponding rise in the vapor ...

Phase Transitions: Melting and Freezing

Heating a crystalline solid increases the average energy of its atoms, molecules, or ions, and the solid gets hotter. At some point, the added energy ...

phase-transitions-sublimation-and-deposition

Phase Transitions: Sublimation and Deposition

Some solids can transition directly into the gaseous state, bypassing the liquid state, via a process known as sublimation. At room temperature and ...

Heating and Cooling Curves

When a substance&#8212;isolated from its environment&#8212;is subjected to heat changes, corresponding changes in temperature and phase of the substance ...

Phase Diagrams

A phase diagram combines plots of pressure versus temperature for the liquid-gas, solid-liquid, and solid-gas phase-transition equilibria of a substance. ...

SC.912.P.8.2

The Atomic Theory of Matter

The earliest recorded discussion of the basic structure of matter comes from ancient Greek philosophers. Leucippus and Democritus argued that all matter ...

Subatomic Particles

Dalton was only partially correct about the particles that make up matter. All matter is composed of atoms, and atoms are composed of three smaller ...

The Wave Nature of Light

The nature of light has been a subject of inquiry since antiquity. In the seventeenth century, Isaac Newton performed experiments with lenses and prisms ...

The Electromagnetic Spectrum

The electromagnetic spectrum consists of all the types of electromagnetic radiation arranged according to their frequency and wavelength. Each of the ...

Interference and Diffraction

Interference is a characteristic phenomenon exhibited by waves. When two electromagnetic waves interact with their peaks and troughs coinciding, a ...

Photoelectric Effect

When light of a particular wavelength strikes a metal surface, electrons are emitted. This is called the photoelectric effect. The minimum frequency of ...

The Bohr Model

Following the work of Ernest Rutherford and his colleagues in the early twentieth century, the picture of atoms consisting of tiny dense nuclei surrounded ...

Emission Spectra

When solids, liquids, or condensed gases are heated sufficiently, they radiate some of the excess energy as light. Photons produced in this manner have a ...

The de Broglie Wavelength

In the macroscopic world, objects that are large enough to be seen by the naked eye follow the rules of classical physics. A billiard ball moving on a ...

The Uncertainty Principle

Werner Heisenberg considered the limits of how accurately one can measure properties of an electron or other microscopic particles. He determined that ...

The Quantum-Mechanical Model of an Atom

Shortly after de Broglie published his ideas that the electron in a hydrogen atom could be better thought of as being a circular standing wave instead of ...

Explore the scientific theory of atoms (also known as atomic theory) by describing changes in the atomic model over time and why those changes were necessitated by experimental evidence.

SC.912.P.8.3

Elements: Chemical Symbols and Isotopes

A chemical symbol is an abbreviation used to indicate an element or an atom of an element. For example, the symbol for mercury is Hg. The same symbol is ...

Ions and Ionic Charges

In ordinary chemical reactions, the nucleus &mdash; which contains the protons and neutrons of each atom and thus identifies the element &mdash; remains ...

The Periodic Table

As early chemists discovered more elements, they realized that various elements could be grouped by their similar chemical behaviors. One such grouping ...

Atomic Mass

Atoms &mdash; and the protons, neutrons, and electrons that compose them &mdash; are extremely small. For example, a carbon atom weighs less than 2 ...

Atomic Number and Mass Number

The number of protons in the nucleus of an atom is its atomic number (Z). This is the defining trait of an element. Its value determines the identity of ...

Explore the scientific theory of atoms (also known as atomic theory) by describing the structure of atoms in terms of protons, neutrons and electrons, and differentiate among these particles in terms of their mass, electrical charges and locations within the atom.

SC.912.P.8.4

Periodic Classification of the Elements

The periodic table arranges atoms based on increasing atomic number so that elements with the same chemical properties recur periodically. When their ...

Electron Configurations

Electron configurations and orbital diagrams can be determined by applying the Aufbau principle (each added electron occupies the subshell of lowest ...

Electronic Structure of Atoms


An atom comprises protons and neutrons, which are contained inside the dense, central&#160;core called the nucleus, with electrons present around the ...

Electron Behavior

Electrons are negatively charged subatomic particles that are attracted to an orbit around the positively-charged nucleus of an atom. They reside in ...

atomic-radii-and-effective-nuclear-charge

Atomic Radii and Effective Nuclear Charge

The elements in groups of the periodic table exhibit similar chemical behavior. This similarity occurs because the members of a group have the same number ...

Atomic Orbitals

An atomic orbital represents the three-dimensional regions in an atom where an electron has the highest probability to reside. The radial distribution ...

The Pauli Exclusion Principle

The arrangement of electrons in the orbitals of an atom is called its electron configuration. We describe an electron configuration with a symbol that ...

The Energies of Atomic Orbitals

In an atom, the negatively charged electrons are attracted to the positively charged nucleus. In a multielectron atom, electron-electron repulsions are ...

The Aufbau Principle and Hund's Rule

To determine the electron configuration for any particular atom, we can build the structures in the order of atomic numbers. Beginning with hydrogen, and ...

electron-configuration-of-multielectron-atoms

Electron Configuration of Multielectron Atoms

The alkali metal sodium (atomic number 11) has one more electron than the neon atom. This electron must go into the lowest-energy subshell available, the ...

Relate properties of atoms and their position in the periodic table to the arrangement of their electrons.

SC.912.P.8.5

Types of Chemical Bonds

Chemical bonding theories were pioneered by American chemist Gilbert&#xA0;N. Lewis. He developed a model called the Lewis model to explain the type and ...

Ionic Bonding and Electron Transfer

Ions are atoms or molecules bearing an electrical charge. A cation (a positive ion) forms when a neutral atom loses one or more electrons from its valence ...

Covalent Bonding and Lewis Structures

Compared to ionic bonds, which results from the transfer of electrons between metallic and nonmetallic atoms, covalent bonds result from the mutual ...

Bonding in Metals

Metallic bonds are formed between two metal atoms. A simplified model to describe metallic bonding has been developed by Paul Dr&#xFC;de called the ...

Intermolecular vs Intramolecular Forces

Intermolecular forces (IMF) are electrostatic attractions arising from charge-charge interactions between molecules. The strength of the intermolecular ...

Intermolecular Forces

Atoms and molecules interact through bonds (or forces): intramolecular and intermolecular. The forces are electrostatic as they arise from interactions ...

Distinguish between bonding forces holding compounds together and other attractive forces, including hydrogen bonding and van der Waals forces.

A. A working definition of matter is that it takes up space, has mass, and has measurable properties. Matter is comprised of atomic, subatomic, and elementary particles.

B. Electrons are key to defining chemical and some physical properties, reactivity, and molecular structures. Repeating (periodic) patterns of physical and chemical properties occur among elements that define groups of elements with similar properties. The periodic table displays the repeating patterns, which are related to the atom's outermost electrons. Atoms bond with each other to form compounds.

C. In a chemical reaction, one or more reactants are transformed into one or more new products. Many factors shape the nature of products and the rates of reaction. 

D. Carbon-based compounds are building-blocks of known life forms on earth and numerous useful natural and synthetic products.

Hydrogen Bonding and DNA Stability

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