Name: radioisotopes in medicine and imaging
Uploaded: 2023-06-23T15:38:43.000Z
Duration: 1 min 28 s
Channel: JoVE

K12 Standards

Pennsylvania State Academic Standards

9-12

Earth and Space Science

Earth's Systems

3.3.9-12.I

Isotopes and Radioisotopes

Isotopes are atoms of an element with the same number of protons but a different number of neutrons, which results in forms of the same element with different mass numbers but same atomic number.
For example, elemental hydrogen has three isotopes - hydrogen with zero, deuterium with one, and tritium with two neutrons.
Usually heavier isotopes of certain elements tend to have an unstable nucleus that emits radiation through radioactive decay, transforming them into other stable non-radioactive products. Such isotopes are called radioisotopes.
For instance, tritium, the heavy isotope of hydrogen, undergoes beta decay. One of its two neutrons is transformed into a proton by the emission of a low energy beta particle producing a more stable non-radioactive helium-three isotope.
Weak radioactive isotopes can be traced inside the human body to study bodily functions and assist in disease diagnosis.
For instance, positron emission tomography uses a fluorine-18 tagged fluorodeoxyglucose radiopharmaceutical to identify cancer cells.
Another radioisotope, thallium-201, is used to monitor blood flow to the heart, aiding in the diagnosis of heart diseases.

isotopes and radioisotopes

In the early 1900s, English chemist Frederick Soddy realized that an element could have atoms with different masses that were chemically indistinguishable. These different types are called isotopes &#8212; atoms of the same element that differ in mass. Isotopes differ in mass because they have different numbers of neutrons but are chemically identical because they have the same number of protons. Soddy was awarded the Nobel Prize in Chemistry in 1921 for this discovery.
An isotope containing more than the usual number of neutrons is called a heavy isotope. Heavy isotopes tend to be unstable, and unstable isotopes are radioactive. A radioactive isotope is an isotope whose nucleus readily decays, giving off subatomic particles and electromagnetic energy. Different radioactive isotopes (radioisotopes) differ in their half-life, the time it takes for half of any size sample of an isotope to decay.
Radioisotopes emit subatomic particles that can be detected and tracked by imaging technologies. Weakly radioactive isotopes, called radiotracers, with short half-lives, can be used in medical imaging. These are usually eliminated from the body within hours or days via lungs, urine, or stool. Due to the low strength of radiation emitted and shorter half-lives, these radiotracers pose no threat of radiation-induced illness.&#160;&#160;
Positron emission tomography detects the activity of radioactive glucose, the simple sugar that cells use for energy. The PET camera reveals which tissues of the patient take up the most glucose. The most metabolically active tissues show up as bright &#34;hot spots&#34; on the images. PET can reveal cancerous masses because cancer cells consume glucose at a high rate to fuel their rapid reproduction.
Excessive exposure to radioactive isotopes can damage human cells and even cause cancer and congenital disabilities, but when exposure is controlled, some radioactive isotopes can be useful in medicine. Radiation therapy uses high-energy radiation to damage the DNA of cancer cells, which kills or keeps them from dividing.
This text is partially adapted from<a href="https://openstax.org/books/chemistry-2e/pages/2-2-evolution-of-atomic-theory?query=isotopes&amp;target=%7B%22type%22%3A%22search%22%2C%22index%22%3A0%7D#fs-idp40043728"> Openstax, Chemistry 2e, Section 2.2 Evolution of Atomic Theory,</a> <a href="https://openstax.org/books/anatomy-and-physiology-2e/pages/2-1-elements-and-atoms-the-building-blocks-of-matter?query=radioisotopes&amp;target=%7B%22type%22%3A%22search%22%2C%22index%22%3A0%7D#fs-id1418017">Openstax, Anatomy and Physiology 2e, Section 2</a><a href="https://openstax.org/books/anatomy-and-physiology-2e/pages/2-1-elements-and-atoms-the-building-blocks-of-matter?query=radioisotopes&amp;target=%7B%22type%22%3A%22search%22%2C%22index%22%3A0%7D#fs-id1418017">.1: Elements and Atoms: the building blocks of matter</a>, <a href="https://openstax.org/books/chemistry-2e/pages/21-5-uses-of-radioisotopes?target=%7B%22index%22%3A0%2C%22type%22%3A%22search%22%7D#fs-idp240963344">and Openstax, Chemistry 2e, Section 21.5: Use of Radioisotopes.</a>

In the early 1900s, English chemist Frederick Soddy realized that an element could have atoms with different masses that were chemically ...

Education

JoVE Core

Anatomy and Physiology

Unit 1

Fundamentals of Chemistry

KEY TERMS AND CONCEPTS

radioisotopes in medicine and imaging

Radioisotopes are unstable isotopes that can be used to study the body and treat disease. An isotope is an atom of the same element that has a different mass because it contains a different number of neutrons. It still has the same number of protons, so it remains chemically identical. English chemist Frederick Soddy explained this idea in the early 1900s and later received the Nobel Prize in Chemistry in 1921.

Some isotopes have more neutrons than usual and are called heavy isotopes. These heavy isotopes are often unstable. A radioactive isotope is an isotope whose nucleus decays and gives off subatomic particles and electromagnetic energy. Radioisotopes differ in half-life, which is the time it takes for half of a sample to decay.

Weakly radioactive isotopes with short half-lives are called radiotracers. They can be used in medical imaging because they emit particles that imaging systems can detect and follow. These tracers are usually removed from the body within hours or days through the lungs, urine, or stool. Because they give off low levels of radiation and disappear quickly, they do not pose a threat of radiation-induced illness.

Positron emission tomography, or PET, uses radioactive glucose, the simple sugar cells use for energy. The PET camera shows which tissues take up the most glucose, and the most active tissues appear as bright hot spots. This helps reveal cancerous masses, since cancer cells use glucose at a high rate to support rapid reproduction. Radioactive isotopes can also be harmful in large amounts, because too much exposure can damage cells and may cause cancer or congenital disabilities. When exposure is controlled, however, radiation therapy can use high-energy radiation to damage cancer cell DNA and stop cells from dividing.

Radioisotopes in Medicine and Imaging

what is matter?

Matter, Mass, and Weight Basics

Matter is the substance that makes up the universe, from a grain of sand to a star. Scientists define matter as anything that occupies space and has mass. Mass is the amount of matter in an object, while weight depends on gravity. Mass stays the same whether an object is on Earth or in the zero-gravity environment of outer space. Weight changes when gravity changes. An object weighs more where gravity is stronger and less where gravity is weaker. A piece of cheese that weighs a pound on Earth...

the periodic table and organismal elements

the-periodic-table-and-organismal-elements

Organismal Elements in the Periodic Table

The periodic table helps identify the elements that make up living organisms. Biology groups these as organismal elements because they are the chemical building blocks of life. These elements are found in different amounts in the body. Some are present in large quantities, while others are needed only in small amounts. The video connects the periodic table to the elements that organisms actually use. Understanding organismal elements helps students link chemistry to biology. It shows how...

atomic structure

From Atomos to the Modern Atom

Atoms are the tiny building blocks of matter, and ideas about them go back to the Greek philosopher Democritus. He suggested that everything on Earth is made of atomos, a Greek word meaning "indivisible." That idea later led to the modern word atom. In the 19th century, John Dalton developed an atomic theory that is still largely correct today. He proposed five key ideas. All matter is made of tiny particles called atoms. Atoms of the same element are alike, and atoms of different elements are...

chemical symbols

Chemical Symbols and Element Names

Chemical symbols are short abbreviations that stand for an element or a single atom of that element. Mercury, for example, has the symbol Hg. The same symbol can point to one atom of mercury in the microscopic domain or to a sample labeled as many atoms of mercury in the macroscopic domain. Many symbols come from the element’s common name. Others are shortened from a name in another language. Most chemical symbols use one or two letters. For a few elements with atomic numbers above 112,...

atomic number and mass number

Atomic Identity, Mass, and Isotopes

Atomic identity depends on the number of protons in the nucleus, and mass depends on protons and neutrons together. The number of protons is the atomic number, or Z. It defines the element. For example, any atom with six protons is carbon, no matter how many neutrons or electrons it has. In a neutral atom, the number of protons equals the number of electrons. Because of that, the atomic number also tells you the number of electrons in the atom. The total number of protons and neutrons is...

atomic weight

Atomic Mass and Mole Calculations

Atomic mass and mole calculations help explain how much matter is in atoms and compounds. Protons and neutrons have about the same mass, about 1.67 × 10 -24 grams. Scientists define that mass as one atomic mass unit, or amu, also called one Dalton. Electrons are much lighter than protons. They weigh only 9.11 × 10 -28 grams, or about 1/1800 of an atomic mass unit. Because of that small mass, electrons do not add much to an element’s overall atomic mass. When chemists calculate atomic mass,...

Radioisotopes are unstable isotopes that can be used to study the body and treat disease. An isotope is an atom of the same element that has a different mass because it contains a different number of neutrons. It still has the same number of protons, so it remains chemically identical. English chemist Frederick Soddy explained this idea in the early 1900s and later received the Nobel Prize in Chemistry in 1921. Some isotopes have more neutrons than usual and are called heavy isotopes. These...

electron behavior

Electron Shells and Discovery

Electrons are negatively charged subatomic particles that stay near the positively charged nucleus of an atom. They occupy spaces linked to energy levels called shells. They are also arranged into subshells and orbitals within each shell. An electron’s shell shows its general energy level. Electrons closer to the nucleus have less energy, while electrons farther away have more energy. The outer shells have more space, so they can hold more electrons than the inner shells. Subshells describe...

introduction to chemical bonds

How Atoms Bond to Reach Stability

Atoms bond to become more stable, and their outermost electrons play the biggest role in that process. The inner electron shell can hold two electrons. The next two shells can each hold eight electrons. This is called the octet rule. It states that, except for the innermost shell, atoms are most stable when their valence shell, or outer shell, has eight electrons. When atoms do not have enough electrons to fill that outer shell, they form chemical bonds with other atoms. A chemical bond is the...

ionic bonds

Ionic Bonds and Charge Transfer

Ionic bonds form when atoms transfer electrons and become charged particles. A positive ion and a negative ion attract each other because opposite charges pull together. This type of bonding helps explain how some substances are held together. In many cases, an atom loses one or more electrons, while another atom gains them. The atom that loses electrons becomes a cation, which is a positively charged ion. The atom that gains electrons becomes an anion, which is a negatively charged ion. The...

covalent bonds

Polar and Nonpolar Covalent Bonds

Covalent bonds form when atoms share electrons to fill their valence shells. The way those shared electrons are pulled depends on electronegativity, which is an atom's tendency to attract electrons in a bond. That difference also helps explain why some molecules are polar and others are nonpolar. Atoms with similar electronegativities form nonpolar covalent bonds. In these bonds, electrons are shared equally, so there is no charge across the molecule. When two atoms have different...

hydrogen bonds

Hydrogen Bonding and DNA Stability

Hydrogen bonding helps explain why some molecules stick together more strongly than others. A hydrogen bond forms when a weakly positive hydrogen atom, already bonded to an electronegative atom, is attracted to another electronegative atom on a nearby polar molecule. Common examples include water, hydrogen fluoride, and ammonia. This attraction happens because hydrogen has a much lower electronegativity than atoms such as fluorine, oxygen, and nitrogen. The electronegativity difference, along...

ions, molecules, and compounds

Atomic Charges, Bonds, and Compounds

Atoms can gain or lose electrons during chemical reactions and become ions. An ion is an atom with an electrical charge. This charge is positive or negative, and it often helps the atom reach a full valence shell. Some atoms are more likely to donate electrons, while others are more likely to accept them. Potassium is one example. It has atomic number 19 and one electron in its valence shell, so it is likely to donate that electron and become a slightly positive ion called a cation. Fluorine...

states of matter

Solids, Liquids, Gases, and Plasma

Solids, liquids, gases, and plasma are the main forms of matter described here. Solids are rigid and keep a definite shape. Liquids flow and take the shape of their container, although gravity gives the surface a flat or slightly curved top. Solids and liquids also have volumes that stay nearly the same even when pressure changes. Gases behave differently from solids and liquids. A gas takes both the shape and the volume of its container. In matter with this behavior, the particles are far...

colloids and suspensions

Suspensions, Sedimentation, and Colloids

Suspensions and colloids are two common kinds of mixtures seen in everyday life. Mud and water, flour and water, and tempera paint are suspensions. These mixtures are heterogeneous, which means their particles are not spread out evenly. The particles are relatively large and can be seen with the naked eye or a magnifying glass. Suspension particles make mixtures cloudy, and they settle out after mixing. The settling of particles in a suspension is called sedimentation. A blood test can measure...

introduction to chemical reactions

Chemical Reaction Basics and Equilibrium

Chemical reactions start with reactants and end with products. Reactants are the substances that enter a reaction, and products are the new substances that form. For example, sodium and chloride ions are the reactants in the formation of table salt. Chemical reactions follow the law of conservation of mass. Matter is not created or destroyed during the reaction. That means the atoms and elements in the reactants are still present in the products, and nothing new appears in the products that...

types of chemical reactions: anabolic and catabolic

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Anabolism, Catabolism, and ATP Use

Anabolism and catabolism are the two main kinds of metabolic reactions in the body. Metabolism is the total set of anabolic and catabolic reactions that keep life running. These reactions follow the first law of thermodynamics, which says energy cannot be created or destroyed. It can only change form. Anabolism builds larger, more complex molecules from smaller ones. These anabolic, or biosynthesis, reactions need energy in the form of ATP. They join monosaccharides into polysaccharides, fatty...

types of chemical reactions: exchange and reversible

types-of-chemical-reactions-exchange-and-reversible

Electron Transfer and Chemical Equilibrium

Exchange reactions and reversible reactions are two important ideas in chemistry. In an exchange reaction, synthesis and decomposition happen at the same time. Chemical bonds are both formed and broken. These reactions can absorb chemical energy, store it, and release it. A special type of exchange reaction is the oxidation-reduction reaction, or redox reaction. In a redox reaction, electrons move from one compound to another. The electrons often come from hydrogen atoms, which contain one...

energy transfer in chemical reactions

Chemical Energy and Reaction Types

Chemical reactions depend on energy transfer, chemical bonds, and the way matter collides. A reaction needs enough energy for particles to meet with the right force and precision. That energy can break old bonds and help form new ones. Kinetic energy is the energy of motion. A person lifting a brick uses kinetic energy to move the brick into place on a wall. Once the wall is built, it stores potential energy, which is the energy of position or structure. If the wall falls, that stored energy...

factors influencing the rate of chemical reactions

factors-influencing-the-rate-of-chemical-reactions

Chemical Reaction Rates and Catalysts

Chemical reaction rates depend on how often particles collide and whether those collisions have enough energy to start a reaction. That starting energy is called activation energy. Factors that affect reaction rate either lower that energy or make successful collisions more likely. Concentration and pressure can speed reactions up because they put more particles in the same space. When more particles are present, they are more likely to bump into one another. Chemists can also increase...

acids, bases and neutralization reactions

How pH Affects Cells and Digestion

Acids, bases, and pH help control how cells and body systems work. In biology, pH can strongly affect enzymes, proteins, and nucleic acids. Enzymes work best within a certain pH range, and pH changes can alter their structure or denature them, which changes how they function. Acids release hydrogen ions, or H+, in solution. A hydrogen ion is a proton, so it is very reactive in chemical reactions. Strong acids release all of their H+ in water and ionize completely. Hydrochloric acid (HCl) is a...

key terms and concepts

Learn how radioisotopes are used in PET scans, radiotracers, and radiation therapy, and why unstable isotopes can help detect and treat disease.

Radioisotopes in Medicine and Imaging | JoVE K12

anatomy and physiology

JoVE Core Anatomy and Physiology showcases the anatomical and physiological details of the human body in comprehensive, clear, and engaging video animations. This collection of lessons focuses on the structures, components, functions, and requirements of the human body. It is complemented by scientist-in-action videos that demonstrate the application of this knowledge in real-world medical and research settings.

History of Earth

3.3.9-12.F

3.3.9-12.G

Tennessee Academic Standards

High School

Chemistry

Matter and Its Interactions

CHEM1.PS1.9

Alabama Course of Study Science

Physical Science

waves-and-their-applications-in-technologies-for-information-transfer

Waves and Their Applications in Technologies for Information Transfer

9-12.PS.2.3.f

9-12.PS.3.4.e

9-12.PS.3.4.f

Next Generation Science Standards

Earth’s Place in the Universe

HS-ESS1-3

Earth’s Systems

HS-ESS2-3

What is Climate?

Climate refers to the prevailing weather conditions in a specific area over an extended period. As the saying goes, &#8220;Climate is what you expect. ...

Global Climate Change

Throughout its ~4.5 billion year history, the Earth has experienced periods of warming and cooling. However, the current drastic increase in global ...

Ecological Disturbance

An ecological disturbance is a temporary disruption in the environment resulting from abiotic, biotic, or anthropogenic factors, causing a pronounced ...

Climate Change

The certainty of climate change remains a public controversy despite the consensus among approximately 97% of active climate researchers, who not only ...

using-topographic-maps-to-generate-topographic-profiles

Using Topographic Maps to Generate Topographic Profiles

Source: Laboratory of Alan Lester - University of Colorado Boulder
Topographic maps are &#34;plan-view&#34; representations of Earth&#39;s ...

Radiation: Applications

The average temperature of Earth is the subject of much current discussion. Earth is in radiative contact with both the Sun and dark space; it receives ...

Momentum And Radiation Pressure

An object absorbing an electromagnetic wave would experience a force in the direction of propagation of the wave. This force occurs because ...

Radiation Pressure: Problem Solving

The radiation pressure applied by an electromagnetic wave on a perfectly absorbing surface equals the energy density of the wave. The wave&#39;s momentum ...

The Electromagnetic Spectrum

The electromagnetic spectrum consists of all the types of electromagnetic radiation arranged according to their frequency and wavelength. Each of the ...

What is Weather?

Overview

Weather refers to the current state of atmospheric conditions at a specific time and place. Weather is temporary and is influenced by the ...

The Wave Nature of Light

The nature of light has been a subject of inquiry since antiquity. In the seventeenth century, Isaac Newton performed experiments with lenses and prisms ...

Mechanisms of Heat Transfer I

Just as interesting as the effects of heat transfer on a system are the methods by which the heat transfer occur. Whenever there is a temperature ...

Mechanisms of Heat Transfer II

In convection, thermal energy is carried by the large-scale flow of matter. Ocean currents and large-scale atmospheric circulation, which result from the ...

Students who demonstrate understanding can analyze geoscience data to make the claim that one change to Earth's surface can create feedback that causes changes to other Earth systems.  Clarification Statement: Examples should include climate feedbacks, such as how an increase in greenhouse gases causes a rise in global temperatures that melts glacial ice, which reduces the amount of sunlight reflected from Earth's surface, increasing surface temperatures and further reducing the amount of ice.  Examples could also be taken from other system interactions, such as how the loss of ground vegetation causes an increase in water runoff and soil erosion;  how dammed rivers increase groundwater recharge, decrease sediment transport, and increase coastal erosion;  or how the loss of wetlands causes a decrease in local humidity that further reduces the wetland extent.  Assessment Boundary:

3.3.9-12.H

Igneous Intrusive Rock

Source: Laboratory of Alan Lester - University of Colorado Boulder
Igneous rocks are products of the cooling and crystallization of high temperature ...

Igneous Volcanic Rock

Source: Laboratory of Alan Lester - University of Colorado Boulder
Igneous rocks are the products of cooling and crystallization of magma. Volcanic rocks ...

an-overview-of-alkenone-biomarker-analysis-for-paleothermometry

An Overview of Alkenone Biomarker Analysis for Paleothermometry

Source: Laboratory of Jeff Salacup&#160;- University of Massachusetts Amherst
Throughout this series of videos, natural samples were extracted and ...

Making a Geologic Cross Section

Source: Laboratory of Alan Lester - University of Colorado Boulder
Geologic maps were first made and utilized in Europe, in the mid-to-late 18th century. ...

Conditions on Early Earth

Nuclear Stability

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Radioactivity and Nuclear Equations

Nuclear chemistry is the study of reactions that involve changes in nuclear structure. The nucleus of an atom is composed of protons and, except for ...

Radioactive Decay and Radiometric Dating

Radioactivity is a spontaneous disintegration of an unstable nuclide and is a random process, as all the nuclei in the sample do not decay simultaneously. ...

Types of Radioactivity

The most common types of radioactivity are &#945; decay, &#946; decay, &#947; decay, neutron emission, and electron capture.
Alpha (&#945;) decay is the ...

Nuclear Power

Controlled nuclear fission reactions are used to generate electricity. Any nuclear reactor that produces power via the fission of uranium or plutonium by ...

Nuclear Fusion

The process of converting very light nuclei into heavier nuclei is also accompanied by the conversion of mass into large amounts of energy, a process ...

Nuclear Transmutation

Nuclear transmutation is the conversion of one nuclide into another. It can occur by the radioactive decay of a nucleus, or the reaction of a nucleus with ...

determining-spatial-orientation-rock-layers-with-brunton

Determining Spatial Orientation of Rock Layers with the Brunton Compass

Source: Laboratory of Alan Lester - University of Colorado Boulder
Most rock units exhibit some form of planar surfaces or linear features. Examples ...

Dynamics of Structures

Source:&#160;Roberto Leon, Department of Civil and Environmental Engineering, Virginia Tech, Blacksburg, VA
It is rare nowadays that a whole year goes by ...

Sound Waves and Doppler Shift

Source: Arianna Brown,&#160;Asantha Cooray, PhD, Department of Physics &#38; Astronomy, School of Physical Sciences, University of California, Irvine, CA
...

Reflection of Waves

When a wave travels from one medium to another, it gets reflected at the boundary of the second medium. A common example of this is when a person yells at ...

Students who demonstrate understanding can develop a model based on evidence of Earth's interior to describe the cycling of matter by thermal convection.  Clarification Statement: Emphasis is on both a one-dimensional model of Earth, with radial layers determined by density, and a three-dimensional model, which is controlled by mantle convection and the resulting plate tectonics.  Examples of evidence include maps of Earth's three-dimensional structure obtained from seismic waves, records of the rate of change of Earth's magnetic field (as constraints on convection in the outer core), and identification of the composition of Earth's layers from high-pressure laboratory experiments.  Assessment Boundary:

Role of Water in Human Biology

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States of Water

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The Water Cycle

The Earth&rsquo;s hydrosphere includes all of the areas where the storage and movement of water occurs. Since water is the basis of all living processes, ...

Cohesion

Cohesion is the attraction between molecules of the same type, such as water molecules. Water molecules have an overall neutral charge but are polar ...

physical-and-chemical-properties-of-matter

Physical and Chemical Properties of Matter

The characteristics that enable us to distinguish one substance from another are called properties.

Physical Properties of Matter

A physical property is ...

Chemistry of the Cell

The cell is chemically composed of water, organic molecules and inorganic ions.
Water
The polarity of the water molecule and its resulting hydrogen ...

Water: A Bronsted-Lowry Acid and Base

The reaction between a Br&#248;nsted-Lowry acid and water is called acid ionization. For example, when hydrogen fluoride dissolves in water and ionizes, ...

The potential of hydrogen (pH) is a measure of the acidity or basicity of a water-based solution determined by the concentration of hydronium ions (H3O+). ...

Solvents

A solvent is a substance, most often a liquid, that can dissolve other substances. Here, the substance being dissolved is called a solute. When a solvent ...

Adhesion

Adhesion occurs when one type of molecule is attracted to a different molecule. Water exhibits adhesive properties in the presence of polar surfaces, such ...

Students who demonstrate understanding can plan and conduct an investigation of the properties of water and its effects on Earth materials and surface processes. [cite: 44] Clarification Statement: Emphasis is on mechanical and chemical investigations with water and a variety of solid materials to provide the evidence for connections between the hydrologic cycle and system interactions commonly known as the rock cycle. [cite: 45] Examples of mechanical investigations include stream transportation and deposition using a stream table, erosion using variations in soil moisture content, or frost wedging by the expansion of water as it freezes. [cite: 46] Examples of chemical investigations include chemical weathering and recrystallization (by testing the solubility of different materials) or melt generation (by examining how water lowers the melting temperature of most solids). [cite: 47] Assessment Boundary:

3.3.9-12.K

What are Biogeochemical Cycles?

The most common elements in organic molecules, carbon, hydrogen, oxygen, nitrogen, sulfur, and phosphorus, are only available in the ecosystem in limited ...

The Carbon Cycle

Carbon is the basis of all organic matter on Earth, and is recycled through the ecosystem in two primary processes: one in which carbon is exchanged among ...

What is Photosynthesis?

Photosynthesis is a multipart, biochemical process that occurs in plants as well as in some bacteria. It captures carbon dioxide and solar energy to ...

Students who demonstrate understanding can develop a quantitative model to describe the cycling of carbon among the hydrosphere, atmosphere, geosphere, and biosphere. [cite: 154] Clarification Statement: Emphasis is on modeling biogeochemical cycles that include the cycling of carbon through the ocean, atmosphere, soil, and biosphere (including humans), providing the foundation for living organisms. [cite: 155] Assessment Boundary:

3.3.9-12.L

Radioisotopes in Medicine and Imaging

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