Guest Editors
Pradeep Joshi
University of California Santa Barbara
Dr. Pradeep Joshi received his BS from the Mumbai University, in 1994, and his MS in Biotechnology from University of Pune in 1996. He obtained his PhD from University of Maryland in 2004. There, he worked with Dr. David Eisenmann to understand the molecular mechanisms of program cell death and the specification of epidermal cell fate in C. elegans. He is currently a project scientist in the laboratory of Dr. Joel Rothman where he studies the non-apoptotic roles of the core cell death regulators as well as the molecular switches governing cell proliferation and differentiation using C. elegans germline stem cells as a paradigm.
Joel Rothman
University of California Santa Barbara
Dr. Joel Rothman received a BS in Biochemistry from UC Davis and earned his PhD from University of Oregon. He was a Helen Hay Whitney and EMBO fellow at MRC, Cambridge and faculty member in Biochemistry at University of Wisconsin, Madison. He then joined MCD Biology at UCSB, where he served as Chair and held a partial faculty appointment at University of Auckland. He was a Searle Scholar and Shaw Scientist and is currently Distinguished Professor and Wilcox Family Chair in Biotechnology. He served as co-director of the Woods Hole MBL Embryology course, the editorial boards of Current Biology, Apoptosis, and Developmental Biology, Chair of the NIH MGB Study Section, and Director of the UCSB HHMI Program. He is currently Director of the Biomolecular Science and Engineering Program, founding Director of the Center for Aging and Longevity Studies, and co-director of the UCSB NIH MARC Program.
Chee Kiang Ewe
University of California Santa Barbara
Chee Kiang Ewe received his BS(Hons) in Biomedical Science from the University of Auckland, New Zealand, in 2015. He is currently completing his PhD at the Department of Molecular, Cellular, and Developmental Biology at the University of California, Santa Barbara. Under the guidance of Dr. Joel Rothman, he studies the regulatory logic governing developmental robustness and the molecular basis underlying variation in the endoderm gene regulatory network in C. elegans.
Collection Overview
Sydney Brenner pioneered the use of Caenorhabditis elegans, specifically the N2 strain isolated from Bristol to study neurodevelopment. Since then, N2 has been instrumental for unraveling fundamental principles in molecular, cellular, and developmental biology. The wealth of knowledge gained from studying N2 over the past five decades has provided a strong base from which to explore the evolutionary diversification of the machinery that modulates development in genetically distinct C. elegans wild isotypes, as well as in other nematode species. To date, more than 500 C. elegans isotypes, each with a unique haplotype, have been isolated from all around the world. This has greatly facilitated the identification of genetic factors responsible for variation in quantitative traits. Many species in the Caenorhabditis genus appear virtually indistinguishable morphologically from C. elegans, providing a strong platform to study the molecular mechanism of developmental system drift; however, interestingly, C. elegans is morphologically substantially different from its closest known fig-associated sibling,C. inopinata, likely as the result of niche adaption. Intra- and interspecies comparative studies will deepen our understanding of the evolutionary history of these animals. Moreover, future quantitative genetic experiments promise to undercover novel regulators and modifiers that give rise to developmental diversity. The goal of this collection is to promote the use of the rich natural resource that nematodes offer to probe important questions in evolutionary developmental biology. We also hope to encourage the development of experimental toolkits for the relatively unexplored nematode species outside of C. elegans.
Editorial
Articles
Culturing and Screening the Plant Parasitic Nematode Ditylenchus dipsaci
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Cited by 2
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2022
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The Large-Scale Cultivation of Nematodes to Study Their Collective Behaviors
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Cited by 1
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2023
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