Aortic Clamping
Aortic Clamping - Related Videos
08:33
Reproducible Arterial Denudation Injury by Infrarenal Abdominal Aortic Clamping in a Murine Model
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Cited by 5 •
2016
Understanding the cellular and molecular mechanisms of re-endothelialization following arterial denudation injury is of paramount importance in preventing thrombosis and restenosis of arteries. Here we describe a protocol for reproducible arterial denudation injury of the infrarenal abdominal aorta. The procedure was developed to investigate the underlying mechanisms that regulate endothelial regeneration using mouse models.
06:50
A Model of Acute Lung Injury Following Visceral Ischemia-Reperfusion by Supra-Coeliac Aortic Cross Clamping in Rats
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Cited by 1 •
2025
This study describes a model of acute lung injury following visceral ischemia-reperfusion during supra-celiac aortic cross-clamping via laparotomy in rats. It enables the investigation of both the clinical and biological effects of aortic clamping as well as the impact of ischemia-reperfusion on underlying organs and remote lung injuries.
12:17
Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
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Cited by 4 •
2017
Full-root aortic valve replacement by stentless aortic xenograft is a viable option in patients with small aortic roots. We describe, a technique for the full-root implantation of stentless aortic xenografts, with emphasis on the management of the proximal suture line and coronary anastomoses, and discuss its limitations and alternative options.
09:12
Aortic Ring Assay
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Cited by 42 •
2009
Angiogenesis, the sprouting of blood vessels from pre-existing vasculature, is associated with both natural and pathological processes. Here we demonstrate an aortic ring assay that allows angiogenic potentiators and inhibitors to be directly added to aortic rings in culture. Sprouting and neovessel outgrowth can be determined by inspecting the aortic rings over a period of 6-12 days.
08:51
A New Murine Model of Endovascular Aortic Aneurysm Repair
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Cited by 3 •
2013
Histological and biochemical modifications after aneurysm endograft exclusion are still unclear. We describe a new model of endograft implantation on a murine aneurysm. Through thrombus analysis with and without persistant circulating blood stream interface, and new endovascular biomaterials evaluation, this model will help to better understand endovascular aneurysm exclusion pathobiology.
FAQs
Clamp location and occlusion time are the principal variables governing the physiological consequences. Positioning determines which vascular territories receive reduced flow, while duration determines how long tissues remain vulnerable to inadequate oxygen delivery. In cardiovascular procedures, these choices help isolate the operative region, but they also require attention to perfusion below the clamp. This makes placement and timing central to limiting ischemic stress.
When blood flow is interrupted in the clamped segment, circulation below it can be supported by alternative pathways or a bypass circuit. This redirection does not simply maintain pressure everywhere; it helps regulate perfusion to downstream tissues while the isolated section is treated. The resulting hemodynamic response depends on where occlusion occurs and how effectively blood flow is redirected.
Ischemia and reperfusion injury are important because tissues below the clamp may experience reduced blood supply during occlusion and damage associated with the return of flow afterward. The severity of these effects is influenced by both clamp position and duration. Monitoring and regulating downstream perfusion therefore supports tissue protection and helps researchers examine how reduced blood flow affects organs.
A controlled approach begins by selecting a clamp location suited to the operative target and then applying temporary occlusion. Clinicians may redirect blood through alternative pathways or a bypass circuit while managing perfusion below the clamp. The practical objective is to isolate the target aortic section, regulate downstream circulation, and avoid unnecessarily prolonged exposure to reduced blood flow.
Aortic clamping supports major cardiovascular procedures, including aortic repair, by separating the section requiring treatment from the rest of the circulation. This temporary isolation gives clinicians a way to control blood flow and pressure while addressing the operative region. Its usefulness depends on maintaining adequate perfusion to tissues below the clamp during the intervention.
In biology and biomedical research, controlled occlusion provides a framework for investigating vascular function, hemodynamic responses, organ protection, and tissue damage caused by reduced blood supply. Researchers can examine how clamp position and duration influence downstream perfusion and injury. These observations connect surgical control of circulation with broader studies of vascular physiology and ischemia-related tissue outcomes.