Gut Liver Axis
Gut Liver Axis - Related Videos
01:22
Gut-Brain Axis
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2026
The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such as...
09:18
A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
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Cited by 10 •
2023
neuroHuMiX is an advanced gut-on-a-chip model to study the interactions of bacterial, epithelial, and neuronal cells under proximal and representative co-culture conditions. This model allows unravelling of the molecular mechanisms underlying the communication between the gut microbiome and the nervous system.
01:15
Assessing the Role of Gut Microbiota in Modulating Hepatitis B Infection in Mice
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2026
Take a control mouse with a normal gut microbiota and an experimental mouse with depleted gut microbiota. The depletion compromises the integrity of the gut barrier.This enables bacteria to translocate through the blood vessel into the liver tissue.Inject both mice with the hepatitis B virus or HBV plasmid to induce an HBV infection in the liver tissue.In the control mouse, the T cell detects an infected liver cell through the interaction of its receptors with viral antigens, and produces...
12:35
In vivo Liver Endocytosis Followed by Purification of Liver Cells by Liver Perfusion
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Cited by 14 •
2011
The study of liver sinusoidal endothelial cells (SECs) must be performed with primary cells obtained from the animal as no cell lines exist. This method relies on liver digestion and differential centrifugation for SEC purification for subsequent culturing and experimentation.
15:27
Extracting DNA from the Gut Microbes of the Termite (Zootermopsis Angusticollis) and Visualizing Gut Microbes
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Cited by 18 •
2007
This video illustrates the technique for extracting DNA from the species of microbes resident in the termite hindgut. The preparation of a wet mount slide, which is useful for visualizing the gut microbial community is also illustrated, and a tour through the species-rich gut environment is given.
FAQs
Bile acids form a two-way signaling component of the gut-liver axis. The liver delivers them to the intestine, where gut microbes modify them before related signals can return through circulation. This exchange connects microbial activity with liver function and helps researchers examine how altered bile acid handling may relate to metabolic or chronic liver disease.
The intestinal barrier helps regulate which signals and microbial products pass from the gastrointestinal tract toward the liver. When barrier integrity changes, immune signaling and inflammatory communication can also change, affecting both organs. This makes barrier status an important variable when investigating how gut conditions may contribute to liver inflammation or disease-related processes.
Microbial imbalance can alter the signals and metabolites exchanged between the intestine and liver, while inflammation can modify immune communication across the same network. Together, these factors provide a biological link between diet-related changes, gastrointestinal disturbances, and liver disorders. Studying them helps explain disease mechanisms without treating the gut or liver in isolation.
Researchers examine interconnected signals, metabolites, bile acid changes, microbial activity, barrier integrity, and immune responses rather than analyzing one organ alone. These observations can be related to dietary patterns, microbial imbalance, inflammation, and disease states. The resulting framework supports investigation of how gastrointestinal and liver abnormalities influence one another and may reveal measurable disease-associated patterns.
Gut-liver axis research can support the search for biomarkers linked to microbial activity, altered metabolites, bile acid processing, intestinal barrier status, immune signaling, or inflammation. Such markers may help characterize metabolic and chronic liver disease and clarify communication between the gastrointestinal tract and liver. Their value depends on how consistently they reflect disease-related changes.
The framework can guide research into microbiome-based interventions and other treatments that target communication between the intestine and liver. Investigators may focus on diet, microbial imbalance, bile acid exchange, barrier integrity, or inflammatory signaling as modifiable features. This systems-level approach is relevant when a disorder involves coordinated gastrointestinal, metabolic, immune, and hepatic changes.